| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2009: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2008: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2007: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Research Abstract |
In this project, we attempted to elucidate the effects of prostaglandin D_2 (PGD_2) which is well-known as a sleep promoter on vascular function. We found that (1) PGD_2 strongly inhibits vascular permeability through its distinct receptor DP, (2) DP agonism represents strong inhibition on tumor vascular permeability, angiogenesis, and growth, (3) While PGD_2 decreases blood pressure through DP activation, excessive amount of PGD_2 can stimulate other PG receptor TP and then increases blood pressure. We published these results in 12 scientific journals and presented in 15 research conferences.
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