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Analysis of G protein signaling pathways involved in the development of heart failure and discovery of the novel therapeutic target.

Research Project

Project/Area Number 19689003
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionKyushu University

Principal Investigator

NISHIDA Motohiro  Kyushu University, 大学院・薬学研究院, 准教授 (90342641)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Keywords薬理学 / 心不全 / シグナル伝達 / G蛋白質 / カルシウム / イオンチャネル / チャネル / 心肥大 / 線維化 / 受容体 / TRP / 圧負荷 / G 蛋白質 / Ca ^<2+>チャネル / transient receptor potential
Research Abstract

We focused on the roles of heterotrimeric G proteins coupling with receptors on the plasma membrane, and found that Gq protein singaling participates in the development of myocardial hypertrophy while G12 protein signaling participates in the development of cardiac fibrosis. In addition, we identified that TRPC channels mediate Gq-induced activation of Ca2+ signaling, and P2Y6 receptor triggers activation of G12 protein signaling. Furthermore, we found that inhibition of these targets improves heart failure in in vivo mouse hearts.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (89 results)

All 2010 2009 2008 2007 Other

All Journal Article (48 results) (of which Peer Reviewed: 12 results) Presentation (36 results) Remarks (5 results)

  • [Journal Article] Ca2+ influx and protein scaffolding via TRPC3 sustain PKCb and ERK activation in B cells.2010

    • Author(s)
      Numaga T, Nishida M, Kiyonaka S, Kato K, Katano M, Mori E, Kurosaki T, Inoue R, Hikida M, Putney JW Jr, Mori Y
    • Journal Title

      J Cell Sci. 123

      Pages: 927-938

    • Related Report
      2009 Final Research Report
  • [Journal Article] Determining the activation of Rho as an index of coupling to G12/13.Chapter for "Receptor Signal Transduction Protocols" as part of the Humana Press2010

    • Author(s)
      Nakaya M, Ohba M, Nishdia M, Kurose H
    • Journal Title

      Methods in Molecular Biology(series) Vol.83

    • Related Report
      2009 Final Research Report
  • [Journal Article] カルシウムシグナリング研究の最前線~電位非依存性カルシウムチャネルの様々な生理・病理機能~2010

    • Author(s)
      西田基宏
    • Journal Title

      YAKUGAKU ZASSHI Vol.130,No.3

      Pages: 279-280

    • NAID

      130000259508

    • Related Report
      2009 Final Research Report
  • [Journal Article] ジアシルグリセロール感受性TRPCチャネルを介した心肥大誘導のメカニズム2010

    • Author(s)
      西田基宏, 渡辺健太, 仲矢道雄, 黒瀬等
    • Journal Title

      YAKUGAKU ZASSHI Vol.130,No.3

      Pages: 295-302

    • NAID

      130000259511

    • Related Report
      2009 Final Research Report
  • [Journal Article] 森泰生TRPCチャネルを標的とした新規Ca2+拮抗薬の創製2010

    • Author(s)
      清中茂樹, 加藤賢太, 西田基宏
    • Journal Title

      YAKUGAKU ZASSHI Vol.130,No.3

      Pages: 303-311

    • Related Report
      2009 Final Research Report
  • [Journal Article] 三量体g蛋白質シグナリングを介した心不全発症の分子機構2010

    • Author(s)
      西田基宏, 大場三奈, 仲矢道雄, 黒瀬等
    • Journal Title

      日本薬理学雑誌 (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Ca^<2+> influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells.2010

    • Author(s)
      Numaga, et al.(全11名中2番目)
    • Journal Title

      J.Cell.Sci. 123

      Pages: 927-938

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition.2010

    • Author(s)
      Nishida M, et al.(全8名)
    • Journal Title

      J.Biol.Chem. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation.2010

    • Author(s)
      Nishida M, et al.(全9名)
    • Journal Title

      J.Biol.Chem. (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Determining the activation of Rho as an index of coupling to G_<12/13>.2010

    • Author(s)
      Nakaya M, et al.(全4名中3番目)
    • Journal Title

      Chapter for "Receptor Singnal Transduction Protocols" as part of the Humana Press"Methods in Molecular Biology" series 83(in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Heterotrimeric G proteins in heart failure.2010

    • Author(s)
      Nishida M, et al.(全4名)
    • Journal Title

      Heart Failure : Symptoms, Causes and Treatment Options. (Nova Science Publishers) (in press)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ジアシルグリセロール感受性TRPCチャネルを介した心肥大誘導のメカニズム2010

    • Author(s)
      西田基宏, 渡辺健太, 仲矢道雄, 黒瀬等
    • Journal Title

      YAKUGAKU ZASSHI 130

      Pages: 295-302

    • NAID

      130000259511

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Amphotericin B-Induced Renal Tubular Cell Injury is Mediated by Na+ Influx through Ion-Permeable Pores and Subsequent Activation of MAP Kinases and Elevation of Intracellular Ca2+.2009

    • Author(s)
      Yano T, Itoh Y, Kawamura E, Maeda A, Egashira N, Nishida M, Kurose H, Oishi R
    • Journal Title

      Antimicrob Agents Chemother. 53

      Pages: 1420-1426

    • Related Report
      2009 Final Research Report
  • [Journal Article] Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound.2009

    • Author(s)
      Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, Mori Y
    • Journal Title

      Proc Natl Acad Sci USA. 106

      Pages: 5400-5405

    • Related Report
      2009 Final Research Report
  • [Journal Article] AT1受容体を介する心肥大形成におけるTRPCチャネルの役割2009

    • Author(s)
      黒瀬等、西田基宏
    • Journal Title

      医学のあゆみ Vol.228,No.5

      Pages: 395-399

    • Related Report
      2009 Final Research Report
  • [Journal Article] TRPチャネルタンパク質の新たな機能と病態生理(序文)2009

    • Author(s)
      西田基宏
    • Journal Title

      日薬理誌 Vol.134,No.3

      Pages: 115-115

    • NAID

      10025741414

    • Related Report
      2009 Final Research Report
  • [Journal Article] Gタンパク質共役型受容体-TRPCチャネルタンパク複合体形成による心肥大シグナル制御2009

    • Author(s)
      西田基宏, 佐藤陽治, 仲矢道雄, 黒瀬等
    • Journal Title

      日本薬理学雑誌 Vol.134,No.3

      Pages: 131-136

    • NAID

      10025741479

    • Related Report
      2009 Final Research Report
  • [Journal Article] Amphotericin B-Induced Renal Tubular Cell Injury is Mediated by Na^+ Influx through Ion-Permeable Pores and Subsequent Activation of MAP Kinases and Elevation of Intracellular Ca^<2+>.2009

    • Author(s)
      Yano T, et al.(全8名中6番目)
    • Journal Title

      Antimicrob Agents Chemother. 53

      Pages: 1420-1426

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AT1受容体を介する心肥大形成におけるTRPCチャネルの役割2009

    • Author(s)
      黒瀬等、西田基宏
    • Journal Title

      医学のあゆみ 228

      Pages: 395-399

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Gタンパク質共役型受容体-TRPCチャネルタンパク複合体形成による心肥大シグナル制御2009

    • Author(s)
      西田基宏, 佐藤陽治, 仲矢道雄, 黒瀬等
    • Journal Title

      日本薬理学雑誌 134

      Pages: 131-136

    • NAID

      10025741479

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Amphotericin B-Induced Renal Tubular Cell Injury is Mediated by Na^+ Influx through Ion-Permeable Pores and Subsequent Activation of MAP Kinases and Elevation of Intracellular Ca^<2+>2009

    • Author(s)
      Yano T, Itoh Y, Kawamura E, Maeda A, Egashira N, Nishida M, Kurose H & Oishi R
    • Journal Title

      Antimicrob Agents Chemother (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ar1受容体を介する心肥大形成におけるTRpcチャネルの役割2009

    • Author(s)
      黒瀬等、西田基宏
    • Journal Title

      医学のあゆみ 228

      Pages: 395-399

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells.2008

    • Author(s)
      Kusano Y, Horie S, Shibata T, Satsu H, Shimizu M, Hitomi E, Nishida M, Kurose H, Itoh K, Kobayashi A, Yamamoto M, Uchida K.
    • Journal Title

      Biochemistry 47

      Pages: 6169-77

    • Related Report
      2009 Final Research Report
  • [Journal Article] A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction.2008

    • Author(s)
      Shibata T, Nakahara H, Kita N, Matsubara Y, Han C, Morimitsu Y, Iwamoto N, Kumagai Y, Nishida M, Kurose H, Aoki N, Ojika M, Uchida K.
    • Journal Title

      J Neurochem. 107

      Pages: 1248-1260

    • Related Report
      2009 Final Research Report
  • [Journal Article] P2Y_6 Receptor-Gα_<12/13> Signaling in Cardiomyocytes Triggers Pressure Overload-induced Cardiac Fibrosis.2008

    • Author(s)
      Nishida M, Sato Y, Uemura A, Narita Y, Tozaki-Saitoh H, Nakaya M, Ide T, Suzuki K, Inoue K, Nagao T, Kurose H.
    • Journal Title

      EMBO J 27

      Pages: 3104-3115

    • Related Report
      2009 Final Research Report
  • [Journal Article] Roles of TRP channels in the development of cardiac hypertrophy.2008

    • Author(s)
      Nishida M, Kurose H
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol. 378

      Pages: 395-406

    • Related Report
      2009 Final Research Report
  • [Journal Article] 機械的伸展刺激により活性化されるGタンパク質共役型受容体の解析2008

    • Author(s)
      西田基宏、上村綾、仲矢道雄、黒瀬等
    • Journal Title

      表面 Vol.46,No.3

    • Related Report
      2009 Final Research Report
  • [Journal Article] 心不全治療の新たな標的としてのTRPCチャネル2008

    • Author(s)
      西田基宏
    • Journal Title

      日本薬理学雑誌 Vol.132,No.8

      Pages: 130-131

    • Related Report
      2009 Final Research Report
  • [Journal Article] P2Y_6 Receptor-Gα_(12/13) Signaling in Cardiomyocytes Triggers Pressure Overload-induced Cardiac Fibrosis2008

    • Author(s)
      Nishida M, et.al.(全11名)
    • Journal Title

      EMBO J. 27

      Pages: 3104-3115

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Keapl regulates the constitutive expression of GST Al during differentiation of Caco-2 cells2008

    • Author(s)
      Kusano Y,…_Nishida M (7)_Uchida K.(全12名)
    • Journal Title

      Biochemistry 47

      Pages: 6169-6177

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A food-derived synergist of NGF signaling : Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-init iated sianal transduction2008

    • Author(s)
      Shibata T,…Nishida M (9)…, Uchida K.(全13名)
    • Journal Title

      J Neurochem 107

      Pages: 1248-1260

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of TRP channels in the development of cardiac hypertrophy2008

    • Author(s)
      Nishida M and Kurose H
    • Journal Title

      Naunyn Schmiedebergs Arch Pharmacol 378

      Pages: 395-406

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective and direct inhibition of TRPC3 channels underlies biological activities of a nvrazole comnound2008

    • Author(s)
      Kiyonaka S, Kato K, Nishida M, et al. (全22名)
    • Journal Title

      Proc Natl Acad Sci USA (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心不全治療の新たな標的としてのTRPCチャネル2008

    • Author(s)
      西田基宏
    • Journal Title

      日本薬理学雑誌 132

      Pages: 130-131

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 機械的伸展刺激により活性化されるGタンパク質共役型受容体の解析2008

    • Author(s)
      西田基宏, 上村綾, 仲矢道雄, 黒瀬等
    • Journal Title

      表面 46

      Pages: 132-142

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Gα_<12/13>-mediated upregulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through NFAT activation.2007

    • Author(s)
      Nishida M, Onohara N, Sato Y, Suda R, Ogushi M, Tanabe S, Inoue R, Mori Y, Kurose H.
    • Journal Title

      J. Biol. Chem. 282

      Pages: 23117-23128

    • Related Report
      2009 Final Research Report
  • [Journal Article] Transient receptor potential channels in Alzheimer's disease.2007

    • Author(s)
      Yamamoto S, Wajima T, Hara Y, Nishida M, Mori Y
    • Journal Title

      Biochim Biophys Acta 1772

      Pages: 958-967

    • Related Report
      2009 Final Research Report
  • [Journal Article] TRPチャネルと心疾患2007

    • Author(s)
      黒瀬等、西田基宏
    • Journal Title

      生化学 Vol.79,No.10

    • Related Report
      2009 Final Research Report
  • [Journal Article] アンジオテンシンIIで誘発される心肥大の分子機構-TRP蛋白質を巡って2007

    • Author(s)
      西田基宏、小野原直哉、井上隆司、森泰生、黒瀬等
    • Journal Title

      日本臨床生理学会雑誌 Vol.37,No.4

    • Related Report
      2009 Final Research Report
  • [Journal Article] イオンチャネルと心疾患-心肥大形成とTRPC-NFATシグナリング2007

    • Author(s)
      黒瀬等、西田基宏
    • Journal Title

      医学のあゆみ Vol.223,No.6

    • Related Report
      2009 Final Research Report
  • [Journal Article] Ga12/13-mediated upregulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through NFAT activation.2007

    • Author(s)
      Nishida, M・Onohara, N・Sato, Y・Suda, R・Ogushi, M・Tanabe, S・Inoue, R・Mori, Y・Kurose, H.
    • Journal Title

      The Journal of Biological Chemistry 282

      Pages: 23117-23128

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transient receptor potential channels in Alzheimer's disease.2007

    • Author(s)
      Yamamoto, S・Wajima, T・Hara, Y・Nishida, M・Mori, Y.
    • Journal Title

      Biochim Biophys Acta.(review) 1772

      Pages: 958-967

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPチャネルと心疾患2007

    • Author(s)
      黒瀬等, 西田基宏
    • Journal Title

      生化学雑誌 79

      Pages: 953-956

    • Related Report
      2007 Annual Research Report
  • [Journal Article] アンジオテンシンIIで誘発される心肥大の分子機構-TRP蛋白質を巡って2007

    • Author(s)
      西田基宏, 小野原直哉, 井上隆司, 森泰生, 黒瀬等
    • Journal Title

      日本臨床生理学会雑誌 37

      Pages: 171-175

    • Related Report
      2007 Annual Research Report
  • [Journal Article] イオンチャネルと心疾患-心肥大形成とTRPC-NFATシグナリング2007

    • Author(s)
      黒瀬等, 西田基宏
    • Journal Title

      医学のあゆみ 223

      Pages: 464-468

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Inoue R and Kurose H. Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition.

    • Author(s)
      Nishida M, Watanabe K, Sato Y, Nakaya M, Kitajima K, Ide T
    • Journal Title

      J. Biol. Chem. (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Pertussis toxin upregulates angiotensin type1 receptors through TLR4-mediated Rac activation.

    • Author(s)
      Nishida M, Suda R, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Sumimoto H, Sato Y, Kurose H.
    • Journal Title

      J. Biol. Chem (in press)

    • Related Report
      2009 Final Research Report
  • [Journal Article] Heterotrimeric G proteins in heart failure.

    • Author(s)
      Nishida M, Ohba M, Nakaya M, Kurose H
    • Journal Title

      Heart Failure: Symptoms, Causes and Treatment Options. (in press.)

    • Related Report
      2009 Final Research Report
  • [Presentation] Diacylglycerol-activated TRPC channels as a new therapeutic target of heart failure.2010

    • Author(s)
      Nishida M
    • Organizer
      The 9^<th> International Symposium on 'Recent Trends in Pharmaceutical Sciences'
    • Place of Presentation
      Yeungnam University, Gyeongsan, Korea
    • Year and Date
      2010-02-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Diacylglycerol activated TRPC channels as a new therapeutic target of heart failure.2010

    • Author(s)
      Nishida M
    • Organizer
      The 9^<th> International Symposium on 'Recent Trends in Pharmaceutical Sciences'.
    • Place of Presentation
      韓国(Yeungnam University, Gyeongsan)
    • Year and Date
      2010-02-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] s-ニトロシル化修飾によるアンジオテンシン受容体シグナリングの調節2010

    • Author(s)
      西田基宏, 仲矢道雄, 黒瀬等
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Final Research Report
  • [Presentation] 心肥大を仲介するTRPCチャネル2010

    • Author(s)
      西田基宏, 黒瀬等, 渡辺健太, 清中茂樹, 森泰生
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] TRPCチャネルのリン酸化による血管緊張性の制御2010

    • Author(s)
      西田基宏, 西岡絹恵, 有吉麻里奈, 仲矢道雄, 黒瀬等
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 心不全を制御する三量体g蛋白質2010

    • Author(s)
      西田基宏
    • Organizer
      京都大学先端医工学研究ユニットh21年度研究発表交流会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of diacylglycerol-activated TRPC channels in the development of heart failure.2009

    • Author(s)
      Nishida M
    • Organizer
      The 6th Japan-Korea Conference on Cellular Signaling for Young Scientists.
    • Place of Presentation
      Huis Ten Bosch, Nagasaki, Japan
    • Year and Date
      2009-11-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Role of diacylglycerol-activated TRPC channels in the development of heart failure.2009

    • Author(s)
      Nishida M
    • Organizer
      The 6^<th> Japan-Korea Conference on Cellular Signaling for Young Scientists.
    • Place of Presentation
      長崎ハウスインボス
    • Year and Date
      2009-11-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] Purinergic P2Y6 Receptor in Cardiomyocytes Initiates Pressure Overload-induced Cardiac Fibrosis.2009

    • Author(s)
      Nishida M, Uemura A, Nakaya M, Kurose H.
    • Organizer
      2009' International Symposium for Pharmaceutical Sciences.
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-11-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Purinergic P2Y_6 Receptor in Cardiomyocytes Initiates Pressure Overload-induced Cardiac Fibrosis.2009

    • Author(s)
      Nishida M, Uemura A, Nakaya M, Kurose H.
    • Organizer
      2009' International Symposium for Pharmaceutical Sciences.
    • Place of Presentation
      福岡
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 転写因子のシステイン修飾による受容体の発現調節2009

    • Author(s)
      黒瀬等, 西田基宏, 大串真理子, 須田玲子, 仲矢道雄
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Down-regulation of angiotensin receptors by S-nitrosylation of NF-κB. Society for Free Radical Research (SFRR) International.2009

    • Author(s)
      Nishida M
    • Organizer
      Free Radical School in Japan 2009
    • Place of Presentation
      Nagano
    • Year and Date
      2009-09-03
    • Related Report
      2009 Final Research Report
  • [Presentation] TRPC channels as a new therapeutic target for heart failure.2009

    • Author(s)
      Nishida M
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-07-29
    • Related Report
      2009 Final Research Report
  • [Presentation] TRPC channels as a new threapeutic target for heart failure.2009

    • Author(s)
      Nishida M
    • Organizer
      The 36^<th> Congress of the International Union of Physiological Sciences (IUPS2009)
    • Place of Presentation
      京都
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] P2Y6 receptor-Gα12/13 signaling triggers pressure overload-induced cardiac fibrosis.2009

    • Author(s)
      Nishida M, Sato Y, Uemura A, Tozaki-Saitoh H, Nakaya M, Inoue K, Kurose H
    • Organizer
      Fukuoka Purine 2009 (Joint with JSPS Core-to-Core Program A Satellite Symposium for IUPS2009)
    • Place of Presentation
      Fukuoka
    • Related Report
      2009 Final Research Report
  • [Presentation] 受容体-TRPCチャネルの機能的共役による心肥大シグナル制御2009

    • Author(s)
      西田基宏、佐藤陽治、仲矢道雄、井上隆司、森泰生、黒瀬等
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 心臓の病的肥大におけるTRPCチャネルの役割2009

    • Author(s)
      西田基宏、佐藤陽治、井上隆司、森泰生、黒瀬等
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 百日咳毒素によるアンジオテンシン受容体発現増加のメカニズム2009

    • Author(s)
      西田基宏, 仲矢道雄, 黒瀬等
    • Organizer
      次世代を担う創薬・医療薬理シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Heterologous down-regulation of angiotensin type1 receptor by purinergic P2Y2 receptor stimulation.2009

    • Author(s)
      Nishida M, Ogushi M, Suda R, Nakaya M, Kurose H
    • Organizer
      The 36th Congress of the International Union of Physiological Sciences
    • Place of Presentation
      July, Kyoto
    • Related Report
      2009 Final Research Report
  • [Presentation] Extracellular nucleotides trigger pressure overload-induced cardiac fibrosis through P2Y_6R-Gα_(12/13) signaling pathways2008

    • Author(s)
      Nishida M
    • Organizer
      KUSCR Japan/Korea Confbrence on Cellular Signaling 2008.(国際シンポジウム)
    • Place of Presentation
      九州大学
    • Year and Date
      2008-12-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Extracellular nucleotides trigger pressure overload-induced cardiac fibrosis through P2Y_6R-Gα_<12/13> signaling pathways.2008

    • Author(s)
      Nishida M
    • Organizer
      KUSCR Japan/Korea Conference on Cellular Signaling 2008.
    • Place of Presentation
      Fukuoka
    • Related Report
      2009 Final Research Report
  • [Presentation] S-ニトロシル化修飾によるアンジオテンシン受容体の調節機構2008

    • Author(s)
      西田基宏、大串真理子、須田玲子、仲矢道雄、黒瀬等
    • Organizer
      生化学会・分子生物学会合同大会BMB2008
    • Place of Presentation
      神戸
    • Related Report
      2009 Final Research Report
  • [Presentation] アンジオテンシン受容体の調節機構2008

    • Author(s)
      黒瀬等、西田基宏、仲矢道雄、須田玲子、大串真理子
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] アドリアマイシン誘発心毒性に対するクロライドチャネル阻害剤の抑制効果2008

    • Author(s)
      上村綾、西田基宏、仲矢道雄、堀江幸世、小野原直哉、矢野貴久、伊藤義規、大石了三、黒瀬等
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] ドキソルビシン誘発心毒性に対するクロライドチャネル阻害剤DIDSの保護機序2008

    • Author(s)
      入佐俊弘、矢野貴久、江頭伸昭、伊藤義規、西田基宏、黒瀬等、大石了三
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 受容体活性化型TRPC3チャネル選択的拮抗剤の開発2008

    • Author(s)
      加藤賢太、清中茂樹、西田基宏、石井正和、森恵美子、沼賀拓郎、吉田卓史、三木崇史、小林力、森井孝、浜地格、若森実、森泰生
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 百日咳毒素による低分子量G蛋白質Racを介したアンジオテンシン受容体の発現増加2008

    • Author(s)
      西田基宏、須田玲子、佐藤陽治、小野原直哉、田辺思帆里、仲矢道雄、黒瀬等
    • Organizer
      第81回日本薬理学会年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 一酸化窒素によるTRPC6チャネルの抑制とその意義2008

    • Author(s)
      小田真司、仲矢道雄、西田基宏、黒瀬等
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] 酸化ストレスによる心筋細胞死におけるAGS3の役割2008

    • Author(s)
      土岐優仁、仲矢道雄、西田基宏、黒瀬等
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of TRPC channels in agonist-induced cardiac hypertrophy.2007

    • Author(s)
      Nishida M, Nakaya M, Kurose H
    • Organizer
      2007' International Symposium for Pharmaceutical Sciences.
    • Place of Presentation
      Nagasaki
    • Related Report
      2009 Final Research Report
  • [Presentation] 心不全治療の新たな標的としてのTRPCチャネル2007

    • Author(s)
      西田基宏
    • Organizer
      第279回情報計算化学生物(CBI)学会研究講演会
    • Related Report
      2009 Final Research Report
  • [Presentation] アンジオテンシンIIによる心筋細胞の肥大応答におけるTRPC3/TRPC6チャネルの関与2007

    • Author(s)
      西田基宏、小野原直哉、井上隆司、住本英樹、佐藤陽治、森泰生、長尾拓、黒瀬等
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] Gα_<13>-TRPC6-NFAT signaling pathway negatively regulates cardiac myofibroblast formation.2007

    • Author(s)
      Nishida M, Onohara N, Kurose H
    • Organizer
      XIX World Congress of the ISHR Bologna
    • Place of Presentation
      Italy
    • Related Report
      2009 Final Research Report
  • [Presentation] Gα_<13>-TRPC6-NFAT signaling pathway negatively regulates cardiac myofibroblast formation.2007

    • Author(s)
      Nishida, M・Onohara, N・Kurose, H
    • Organizer
      XIX World Congress of the ISHR
    • Place of Presentation
      Italia(Bologna)
    • Related Report
      2007 Annual Research Report
  • [Presentation] Race up-regulates angiotensin II type 1 receptors through IL-1β production in rat cardiac fibroblasts.2007

    • Author(s)
      Kurose, H・Suda, R・Onohara, N・Nishida, M.
    • Organizer
      XIX World Congress of the ISHR
    • Place of Presentation
      Italia(Bologna)
    • Related Report
      2007 Annual Research Report
  • [Presentation] 心不全治療の新たな標的としてのTRPCチャネル2007

    • Author(s)
      西田基宏
    • Organizer
      第279回日本化学会・CBI学会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://210.233.60.66/~chudoku/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://210.233.60.66/~chudoku/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://biotech.nikkeibp.co.jp/bionewsn/detail.jsp?id=20060676&newsid=SPC2009031663068&pg_nm=1&sail=0&newl=1&newsl=1&icate=0&yunw=1

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://210.233.60.66/~chudoku/nishida.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://chudoku.phar.kyushu-u.ac.jp/

    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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