| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2007: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Research Abstract |
To understand the underlying mechanisms of sex-difference in susceptibility ofarrhythmias induced by long QT intervals, there systemic factors for triggers ofarrhythmias (sex hormones, sympathetic nervous system stimulation, and drugs) wereanalyzed. We then found an involvement of non-genomic action of sex-hormones in the sexdifference, a novel mechanism for regulation of a K+ channel by nitric oxide, and effectsof estrogen on sensitivity of QT-prolonging drugs. These data were introduced into acomputer simulation model of cardiac action potentials. The model could assess the sexdifference of susceptibility of arrhythmias induced by QT-prolonging drugs.
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