Generation and application of the novel mouse model for Alzheimer's disease
| Project/Area Number |
19689009
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SAITO Takashi The Institute of Physical and Chemical Research, 神経蛋白制御研究チーム, 研究員 (90360552)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2009: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2008: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2007: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | アルツハイマー病 / モデルマウス / アミロイド前駆体蛋白 / アミロイドβペプチド / プレセニリン1 / アミロイド前駆体蛋白質(APP) / アミロイドβペプチド(Aβ) / プレセニリン1(PS1) / ノックインマウス / アミロイド前駆体蛋白(APP) / プレセニリン-1 |
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| Research Abstract |
We generated two lines of the novel mouse model for Alzheimer's disease (AD), amyloid precursor protein (APP) knock-in (KI) mouse and presenilin1(PS1)-KI mouse. Each KI mice has the familial AD mutations. The mice showed relevance phenotypes rather than previous AD model mouse. These mice would be a useful tool for the prevention, the treatment and the drug discovery of AD.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Interleukin-1β up-regulates TACE to enhance α-cleavage of APP in neurons: resulting in Aβ production.2008
Author(s)
Y. Tachida, K. Nakagawa, T. Saito, T. Saido, T. Honda, Y. Sato, S. Murayama, T. Endo, G. Sakaguchi, A. Kato, S. Kitazume, Y. Hashimoto
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Journal Title
Journal of Neurochemistry 104
Pages: 1387-1393
Related Report
Peer Reviewed
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