Abdominal obesity measured by multiple sliced CT, plasma adiponectin and colorectal adenoma

• Project/Area Number: 19689014
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
• Principal Investigator: SASAZUKI Shizuka National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, がん予防・検診研究センター 予防研究部, 室長 (50392337)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000); Fiscal Year 2009: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2007: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: 内臓脂肪 / 大腸腺腫 / アデイポネクチン / アディポネクチン / アデポネクチン

Research Abstract

Among 1,205 eligible subjects who underwent PET-CT for cancer screening in Tokyo, visceral fat volume was associated with the prevalence of colorectal adenoma independently of body mass index in both sexes. Plasma level of C-peptide and IGFBP-1 were associated with colorectal adenoma among men but not women. An inverse and positive association of adiponectin and leptin was observed with colorectal adenoma, respectively.

Research Products

• [Journal Article] Methionine synthase A2756G polymorphism interacts with alcohol and folate intake to influence the risk of colorectal adenoma. (2009)
  • Author(s): Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 18 Pages: 267-274
• [Journal Article] Visceral fat volume and the prevalence of colorectal adenoma. (2009)
  • Author(s): Yamaji T, Iwasaki M, Sasazuki S, Kurahashi N, Mutoh M, Yamamoto S, Suzuki M, Moriyama N, Wakabayashi K, Tsugane S.
  • Journal Title: Am J Epidemiol. 170 Pages: 1502-1511
• [Journal Article] Dietary isoflavone and the risk of colorectal adenoma: a case-control study in Japan. (2009)
  • Author(s): Akhter M, Iwasaki M, Yamaji T, Sasazuki S, Tsugane S.
  • Journal Title: Br J Cancer 100 Pages: 1812-1816
• [Journal Article] Visceral fat volume and the prevalence of colorectal adenoma. (2009)
  • Author(s): Yamaji T, Iwasaki M, Sasazuki S, Kurahashi N, Mutoh M, Yamamoto S, Suzuki M, Moriyama N, Wakabayashi K, Tsugane S.
  • Journal Title: Am J Epidemiol 170 Pages: 1502-1511
  • Peer Reviewed
• [Journal Article] Dietary isoflavone and the risk of colorectal adenoma : a case-control study in Japan (2009)
  • Author(s): Akhter M, Iwasaki M, Yamaji T, Sasazuki S, Tsugane S.
  • Journal Title: Br J Cancer 100 Pages: 1812-1816
  • Peer Reviewed
• [Journal Article] Methionine synthase A2756G polymorphism interacts with alcohol and folate intake to influence the risk of colorectal adenoma. (2009)
  • Author(s): Yamaji T, Iwasaki M, Sasazuki S, Sakamoto H, Yoshida T, Tsugane S.
  • Journal Title: Cancer Epidemiol Biomarkers Prev 18 Pages: 267-274
  • Peer Reviewed
• [Journal Article] Development of an automated 3D segmentation program for volume quantification of body fat distribution using CT. (2008)
  • Author(s): Ohshima S, Yamamoto S, Yamaji T, Suzuki M, Mutoh M, Iwasaki M, Sasazuki S, Kotera K, Tsugane S, Muramatsu Y, Moriyama N.
  • Journal Title: Nippon Hoshasen Gijutsu Gakkai Zasshi. 64 Pages: 1177-1181
  • NAID: 110007068971
• [Journal Article] Development of an automated 3D segmentation program for volume quantification of body fat distribution using CT. (2008)
  • Author(s): Ohshima S, Yamamoto S, Yamaji T, Suzuki M, Mutoh M, Iwasaki M, Sasazuki S, Kotera K, Tsugane S, Muramatsu Y, Moriyama N.
  • Journal Title: Nippon Hoshasen Gijutsu Gakkai Zasshi 64 Pages: 1177-1181
  • NAID: 110007068971
  • Peer Reviewed
• [Presentation] Methionine synthase A2756G多型と大腸腺腫との関連 (2009)
  • Author(s): 山地大樹、岩崎基、笹月静、坂本裕美、吉田輝彦、津金昌一郎
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 神奈川県横浜市
• [Remarks]
  • URL: http://epi.ncc.go.jp/mstudy/
• [Remarks]
  • URL: http://epi.ncc.go.jp/jp/mstudy/colon/
• [Remarks]
  • URL: http://www.ncc.go.jp/jp/kenshin/divisions/03prev/03prev05.html