Changes in genes expression following traumatic brain injury
| Project/Area Number |
19689015
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | University of Yamanashi (2008-2009)
Saga University (2007) |
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Principal Investigator |
SHOJO Hideki University of Yamanashi, 大学院・医学工学総合研究部, 講師 (60284626)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2007: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | 頭部外傷 / 受傷応答メカニズム / アポトーシス / マイクロアレイ解析 |
|---|
| Research Abstract |
The ratios of most apoptosis-related gene transcripts changed primarily at 6 and 12 h following traumatic brain injury (TBI). The altered expression ratio decreased significantly at 48 h after trauma. The dynamic changes in expression of apoptosis-related genes were closely paralleled by similar alterations in inflammation-related genes after trauma. The altered genes involved in TBI-induced apoptosis included interleukin 1 and tumor necrotic factor which immediately increased and reached the maximum levels at 3 h following the injury. These results suggested that TBI induced apoptosis relate to inflammation response after trauma.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] Acute treatment of herbal extracts reduces ischemic cell death and improves motor and neurological functions in stroke models.2010
Author(s)
Borlongan CV, Yu S, Kaneko Y, Shojo H, Bae E, Park DH, Eve DJ, Roschek, BJ, Alberte RS, Sanberg PR, Sanberg CD, Bickford PC.
Organizer
17th Annual Conference of the American Society for Neural Therapy & Repair
Place of Presentation
Florida
Year and Date
2010-04-29
Related Report
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