Changes in genes expression following traumatic brain injury

• Project/Area Number: 19689015
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Legal medicine
• Research Institution: University of Yamanashi (2008-2009); Saga University (2007)
• Principal Investigator: SHOJO Hideki University of Yamanashi, 大学院・医学工学総合研究部, 講師 (60284626)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000); Fiscal Year 2009: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000); Fiscal Year 2007: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
• Keywords: 頭部外傷 / 受傷応答メカニズム / アポトーシス / マイクロアレイ解析

Research Abstract

The ratios of most apoptosis-related gene transcripts changed primarily at 6 and 12 h following traumatic brain injury (TBI). The altered expression ratio decreased significantly at 48 h after trauma. The dynamic changes in expression of apoptosis-related genes were closely paralleled by similar alterations in inflammation-related genes after trauma. The altered genes involved in TBI-induced apoptosis included interleukin 1 and tumor necrotic factor which immediately increased and reached the maximum levels at 3 h following the injury. These results suggested that TBI induced apoptosis relate to inflammation response after trauma.

Research Products

• [Journal Article] Brain germinoma in a young adult man with suspicion of fatal neglect. (2009)
  • Author(s): Kibayashi K, Sugita Y, Shojo H, Sumida T.
  • Journal Title: American Journal of Forensic Medicine and Pathology 30(2) Pages: 180-182
  • Peer Reviewed
• [Journal Article] Hyperthermia combined with ethanol administration induces c-fos expression in the central amygdaloid nucleus of the mouse brain. (2009)
  • Author(s): Kibayashi K, Nakao KI, Shojo H.
  • Journal Title: International Journal of Legal Medicine 123(5) Pages: 371-379
  • Peer Reviewed
• [Journal Article] Hyperthermia combined with ethanol administration inducesc-fos expression in the central amygdaloid nucleus of the mouse brain. A possible mechanism of heatstroke under the influence of ethanol intake. (2009)
  • Author(s): Kibayashi K
  • Journal Title: Int J Legal Med 123 Pages: 371-379
  • Peer Reviewed
• [Journal Article] Brain germinoma in a young adult man with suspicion of fatalneglect. (2009)
  • Author(s): Kibayashi K
  • Journal Title: Am J of Forensic Med Pathol 30 Pages: 180-182
  • Peer Reviewed
• [Journal Article] Effects of Tissue Fixation on the Inhibition of Erythrocyte Pseudoperoxidase Activity in Immunoperoxidase Methods. (2008)
  • Author(s): Sumida T, Kibayashi K, Shojo H, Nakao KI.
  • Journal Title: Journal of Histotechnology 31(4) Pages: 165-168
  • Peer Reviewed
• [Journal Article] An unusual case suspected of accidental death from head-down position. (2008)
  • Author(s): Kibayashi K, Sumida T, Shojo H.
  • Journal Title: Acta Criminologiae et Medicinase Legalis Japonica 74 Pages: 31-35
  • NAID: 10025715375
  • Peer Reviewed
• [Journal Article] An unusual case suspected of accidental death from head-down position (2008)
  • Author(s): Kibayashi Kazuhiko
  • Journal Title: Acta Crim Japon 74 Pages: 31-35
  • Peer Reviewed
• [Journal Article] Brain germinoma in young adult male with suspicion of fatal neglect. (2008)
  • Author(s): Kazuhiko Kibayashi
  • Journal Title: The American Journal of Forensic Medicine and Pathology (in press)
  • Peer Reviewed
• [Journal Article] An unusual case suspected of accidental death from head-down position. (2008)
  • Author(s): Kazuhiko Kibayashi
  • Journal Title: Acta Criminologia et Medicinae Legalis Japonica (in press)
  • Peer Reviewed
• [Journal Article] Unexpected death due to intestinal obstruction by duplication cyst in an infant. (2007)
  • Author(s): Kibayashi K, Sumida T, Shojo H, Tokunaga O.
  • Journal Title: Forensic Science International 173 Pages: 175-177
  • Peer Reviewed
• [Journal Article] Dementing diseases among elderly persons who suffered fatal accidents: a forensic autopsy study. (2007)
  • Author(s): Kibayashi K, Sumida T, Shojo H, Hanada M.
  • Journal Title: American Journal of Forensic Medicine and Pathology 28 Pages: 73-79
  • Peer Reviewed
• [Presentation] Traumatic brain injury-induced apoptosis in the rat cerebral cortex following moderate fluid percussion injury: A target for therapeutic intervention. (2010)
  • Author(s): Shojo H, Kaneko Y, Adachi N, Borlongan CV.
  • Organizer: 17th Annual Conference of the American Society for Neural Therapy & Repair
  • Place of Presentation: Florida
  • Year and Date: 2010-04-29
• [Presentation] Acute treatment of herbal extracts reduces ischemic cell death and improves motor and neurological functions in stroke models. (2010)
  • Author(s): Borlongan CV, Yu S, Kaneko Y, Shojo H, Bae E, Park DH, Eve DJ, Roschek, BJ, Alberte RS, Sanberg PR, Sanberg CD, Bickford PC.
  • Organizer: 17th Annual Conference of the American Society for Neural Therapy & Repair
  • Place of Presentation: Florida
  • Year and Date: 2010-04-29
• [Presentation] a key neuroprotective protein against oxidative stress, ameliorates ischemic cell death in vitro possibly via mitochondrial pathway. (2010)
  • Author(s): Kaneko Y, Shojo H, Yu S, Bae E, Borlongan CV. DJ-1
  • Organizer: Nano-Bio Collaborative Conference
  • Place of Presentation: Florida
  • Year and Date: 2010-03-11
• [Presentation] A key neuroprotective protein against oxidative stress, ameliorates ischemic cell death in vitro possibly via mitochondrial pathway. (2010)
  • Author(s): Kaneko Y
  • Organizer: INano-Bio Collaborative Conference
  • Place of Presentation: Florida
  • Year and Date: 2010-03-11
• [Presentation] National Incidence and Prevalence of Adult-Onset Brain Disorders (2010)
  • Author(s): Borlongan CV, Yu S, Recio J, Burns J, Amatangelo S, Bae E, Shojo H, Sanberg PR, Kaneko Y, Emerich DF.
  • Organizer: 20th USF Health Research Day
  • Place of Presentation: Florida
  • Year and Date: 2010-02-19
• [Presentation] DJ-1, a key neuroprotective protein against Parkinson's disease, ameliorates neuronal cell death in ischemic stroke possibly via mitochondrial pathway. (2010)
  • Author(s): Kaneko Y, Shojo H, Yu S, Bae E, Borlongan CV.
  • Organizer: 20th USF Health Research Day
  • Place of Presentation: Florida
  • Year and Date: 2010-02-19
• [Presentation] National Incidence and Prevalence of Adult-Onset Brain Disorders. (2010)
  • Author(s): Borlongan CV
  • Organizer: 20^<th> USF Health Research Day
  • Place of Presentation: Florida
  • Year and Date: 2010-02-19
• [Presentation] A key neuroprotective protein against Parkinson's disease, ameliorates neuronal cell death in ischemic stroke possibly via mitochondrial pathway. (2010)
  • Author(s): Kaneko Y
  • Organizer: 20^<th> USF Health Research Day
  • Place of Presentation: Florida
  • Year and Date: 2010-02-19
• [Presentation] Neuropathology for traumatic brain injury (2009)
  • Author(s): Shojo H
  • Organizer: University of South Florida
  • Place of Presentation: Florida
  • Year and Date: 2009-08-19
• [Presentation] Neuropathology for traumatic brain injury. (2009)
  • Author(s): Shojo H
  • Organizer: Invitation lecture in University of South Florida.
  • Place of Presentation: Florida
  • Year and Date: 2009-08-19
• [Presentation] 頭部外傷に伴う活性化カスパーゼ-3の経時的変化 (2009)
  • Author(s): 猩々英紀, 安達登
  • Organizer: 第93次日本法医学会学術全国集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-14
• [Presentation] 頭部外傷に伴う活性化カスパーゼ-3の経時的変化. (2009)
  • Author(s): 狸々英紀
  • Organizer: 日本法医学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-14
• [Presentation] 頭部外傷により引き起こされるアポトーシスとマクロファージや神経細胞との関係 (2008)
  • Author(s): 猩々英紀, 木林和彦
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] 脳内異物による脳病態の解析 (2008)
  • Author(s): 中尾賢一朗, 猩々英紀, 木林和彦
  • Organizer: 第92次日本法医学会総会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] 頭部外傷により引き起こされるアポトーシスとマクロファージや神経細胞との関係 (2008)
  • Author(s): 狸々英紀
  • Organizer: 日本法医学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] 脳内異物による脳病態の解析 (2008)
  • Author(s): 中尾賢一朗
  • Organizer: 日本法医学会
  • Place of Presentation: 長崎
  • Year and Date: 2008-04-24
• [Presentation] 脳挫傷により誘導されるアポトーシスの経時的解析 (2007)
  • Author(s): 猩々英紀, 木林和彦
  • Organizer: 日本法医学九州地方会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-20
• [Presentation] 頭部外傷に伴う損傷脳の病態 (2007)
  • Author(s): 猩々英紀
  • Organizer: 佐賀大学統合実験センター講演会
  • Place of Presentation: 佐賀
  • Year and Date: 2007-09-27
• [Presentation] 頭部外傷がアポトーシスに関与する遺伝子に及ぼす影響 (2007)
  • Author(s): 猩々英紀, 木林和彦
  • Organizer: 第91次日本法医学会総会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-18
• [Presentation] 頭部外傷がアポトーシスに関与する遺伝子に及ぼす影響. (2007)
  • Author(s): 猩々英紀
  • Organizer: 日本法医学会
  • Place of Presentation: 秋田
  • Year and Date: 2007-05-18
• [Remarks]
  • URL: http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_61/F8AD215DD10A64A4.html