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The basic and clinical research regarding development of combinationalchemotherapy with nitric oxide donating drugs for non-small cell lung cancer

Research Project

Project/Area Number 19689018
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University (2008-2009)
Kyoto University (2007)

Principal Investigator

YASUDA Hiroyasu  Tohoku University, 未来医工学治療開発センター, 准教授 (90396482)

Co-Investigator(Renkei-kenkyūsha) YANAGIHARA Kazuhiro  京都大学, 大学院・医学系研究科, 准教授 (70332731)
Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2009: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2008: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2007: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Keywords非小細胞肺癌 / 低酸素誘導性抗がん薬耐性化機序 / 低酸素誘導因子 / 腫瘍内微小循環 / 一酸化窒素 / ニトログリセリン / 多施設第II相proof of concept臨床試験 / P糖蛋白 / 血管内皮成長因子 / 生存シグナル / 化学療法 / 多施設無作為化臨床試験 / 腫瘍内低酸素 / 腫瘍微小循環 / 腫瘍循環 / P糖蛋白質
Research Abstract

In basic science, I showed that nitroglycerin (GTN) significantly reduced HIF-1 alpha, P-glycoprotein, VEGF, P-Akt, and P-CREB in tumor tissues in vivo, resulting in enhancing chemosensitivity of cancer cells to anti-cancer drugs including cisplatin and docetaxel. I started and have been performing three clinical trials regarding combinational chemotherapy with GTN for the next phase III trials, as following : 1) Randomized multicenter phase II trial comparing paclitaxel and carboplatin with GTN with paclitaxel and carboplatin alone in patients with previously untreated advanced non-small cell lung cancer (NSCLC) ; 2) Single arm phase II trial of amrubicin and GTN in patients with previously treated advanced NSCLC as third regimen ; 3) Single arm phase II trial of docetaxel and GTN in elderly patients with previously untreated advanced NSCLC.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (88 results)

All 2010 2009 2008 2007 Other

All Journal Article (43 results) (of which Peer Reviewed: 37 results) Presentation (32 results) Book (1 results) Remarks (9 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies.2010

    • Author(s)
      Yasuda H, Yanagihara K, Nakayama K, Mio T, Sasaki T, Asada M, Yamaya M, Fukushima M.
    • Journal Title

      Nitric Oxide and Cancer: Prognosis and Therapy (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of S-1 and docetaxel for previously treated patients with locally advanced or metastatic non-small-cell lung cancer.2010

    • Author(s)
      Yanagihara K, Yoshimura K, Niimi M, Yasuda H, et. al.
    • Journal Title

      Cancer Chemother Pharmacol (in press)

    • NAID

      120002515188

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clarithromycin inhibits type A seasonal influenza virus infection in human airway epithelial cells.2010

    • Author(s)
      Yamaya M, Shinya K, Hatachi Y, Kubo H, Asada M, Yasuda H, Nishimura H, Nagatomi R.
    • Journal Title

      J Pharm Exp Ther 333

      Pages: 81-90

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase II study of S-1 and docetaxel for previously treated patients with locally advanced or metastatic non-small-cell lung cancer2010

    • Author(s)
      Yanagihara K, Yoshimura K, Niimi M, Yasuda H, et al.
    • Journal Title

      Cancer Chemother Pharmacol (In press)

    • NAID

      120002515188

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clarithromycin inhibits type A seasonal influenza virus infection in human airway epithelial cells2010

    • Author(s)
      Yamaya M, Shinya K, Hatachi Y, Kubo H, Asada M, Yasuda H, et al.
    • Journal Title

      J Pharm Exp Ther 333

      Pages: 81-90

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 喀痰調整薬のライノウイルス感染・気道炎症抑制作用と臨床効果2009

    • Author(s)
      安田浩康、佐々木陽彦、中山勝敏、吉田元樹、旗智幸政、永井宏樹、Deng Xue、山谷睦雄
    • Journal Title

      化学療法の領域 25

      Pages: 83-92

    • Related Report
      2009 Final Research Report
  • [Journal Article] Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells.2009

    • Author(s)
      Asada M, Yoshida M, Suzuki T, Yasuda H, et. al.
    • Journal Title

      Antiviral Res 83

      Pages: 191-200

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine- induced neutropenia.2009

    • Author(s)
      Kanai M, Morita S, Matsumoto S, Nishimura T, Hatano E, Yazumi S, Sasaki T, Yasuda H, et. al.
    • Journal Title

      Ann Oncol 20

      Pages: 1397-1401

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fas signal and cancer progression.2009

    • Author(s)
      Yasuda H, Nakayama K, Sasaki T, Yanagihara K.
    • Journal Title

      Immunotherapy 1

      Pages: 337-337

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide and cancer immunity in solid tumor tissues.2009

    • Author(s)
      Yasuda H, Nakayama K, Sasaki T, Yanagihara K.
    • Journal Title

      Immunotherapy 1

      Pages: 338-338

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual antibody plus chemotherapy in metastatic colorectal cancer.2009

    • Author(s)
      Yasuda H, Nakayama K, Sasaki T, Yanagihara K.
    • Journal Title

      Immunotherapy 1

      Pages: 339-340

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells.2009

    • Author(s)
      Yoshida M, Nakayama K, Yasuda H, et. al.
    • Journal Title

      Respirology 14

      Pages: 1027-1034

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A randomized, single blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patients.2009

    • Author(s)
      Sasaki T, Nakayama K, Yasuda H, et. al.
    • Journal Title

      J Am Geriatr Soc 57

      Pages: 1453-1457

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 喀痰調整薬のライノウイルス感染・気道炎症抑制作用と臨床効果2009

    • Author(s)
      安田浩康、佐々木陽彦、中山勝敏, ら
    • Journal Title

      化学療法の領域 25

      Pages: 83-92

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Fas signal and cancer progression2009

    • Author(s)
      Yasuda H, Nakayama K, Sasaki T, Yanagihara K.
    • Journal Title

      Immunotherapy 1

      Pages: 337-337

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nitric oxide and cancer immunity in solid tumor tissues2009

    • Author(s)
      Yasuda H, Nakayama K, Sasaki T, Yanagihara K.
    • Journal Title

      Immunotherapy 1

      Pages: 338-338

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual antibody plus chemotherapy in metastatic colorectal cancer2009

    • Author(s)
      Yasuda H, Nakayama K, Sasaki T, Yanagihara K.
    • Journal Title

      Immunotherapy 1

      Pages: 339-340

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbocisteine inhibits oxidant-induced apoptosis in cultured human airway epithelial cells2009

    • Author(s)
      吉田元樹, 中山勝敏, 安田浩康, et al.
    • Journal Title

      Respirology 14

      Pages: 1027-1034

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomized, single blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patients2009

    • Author(s)
      佐々木陽彦, 中山勝敏, 安田浩康, et al.
    • Journal Title

      J Am Geriatr Soc 57

      Pages: 1453-1457

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 気道疾患2009

    • Author(s)
      山谷睦雄、吉田元樹、中山勝敏、安田浩康, ら
    • Journal Title

      The Lung Perspective 17

      Pages: 43-47

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells2009

    • Author(s)
      Asada M, Yoshida M, Suzuki T, Yasuda H, et al.
    • Journal Title

      Antiviral Res 83

      Pages: 191-200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A history of smoking is inversely correlated with the incidence of gemcitabine-induced neutropenia2009

    • Author(s)
      Kanai M, Morita S, Matsumoto S, et al.
    • Journal Title

      Ann Oncol 20

      Pages: 1397-1401

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter.2008

    • Author(s)
      Asada M, Ebihara S, Numachi Y, Okazaki T, Yamanda S, Ikeda K, Yasuda H, Sora I, Arai H
    • Journal Title

      Int J Cancer 123

      Pages: 511-518

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Solid tumor physiology and hypoxia-induced chemo/radio-resistance: Novel strategy for cancer therapy: Nitric oxide donor as a therapeutic enhancer.2008

    • Author(s)
      Yasuda H.
    • Journal Title

      Nitric Oxide: Biology and Chemistry 19

      Pages: 205-216

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged neutropenia after dose-dense chemotherapy with pegfilgrastim.2008

    • Author(s)
      Ishiguro H, Kitano T, Yoshibayashi H, Toi M, Ueno T, Yasuda H, et. al.
    • Journal Title

      Ann Oncol 19

      Pages: 1019-1019

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clincal outcome of combination therapy of gemcitabine with S-1 for advanced pancreatic cancer.2008

    • Author(s)
      Yamauchi J, Kanai M, Matsumoto S, Nishimura T, Yazumi S, Kamei K, Kawaguchi Y, Yasuda H, et. al.
    • Journal Title

      Pancreas 36

      Pages: 327-328

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Submucosal gland cells in human lower airways produce MUC5AC protein.2008

    • Author(s)
      Inoue D, Kubo H, Watanabe M, Sasaki T, Yasuda H, et. al.
    • Journal Title

      Respirology 13

      Pages: 285-287

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14.2008

    • Author(s)
      Inoue D, Kubo H, Sasaki T, Yasuda H, et. al.
    • Journal Title

      Respirology 13

      Pages: 215-220

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Solid tumor physiology and hypoxiainduced chemo / radioresistance : Novel strategy for cancer therapy : Nitric oxide donor as a therapeutic enhancer2008

    • Author(s)
      Yasuda H
    • Journal Title

      Nitric Oxide : Biology and Chemistry 19

      Pages: 205-216

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged neutropenia after dose-dense chemotherapy with pegfilgrastim2008

    • Author(s)
      Ishiguro H, et.al.
    • Journal Title

      Ann Oncol 19

      Pages: 1019-1019

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter2008

    • Author(s)
      Asada M, et.al.
    • Journal Title

      Int J Cancer 123

      Pages: 511-518

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and incidence of anemia in Japanese cancer patients receiving outpatient chemotherapy.2007

    • Author(s)
      Kitano T, Tada H, Nishimura T, Teramukai S, Kanai M, Nishimura T, Misawa A, Yoshikawa K, Yasuda H, et. al.
    • Journal Title

      Int J Hematol 86

      Pages: 37-41

    • NAID

      10018515509

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor hypoxia imaging with[F-18]fluoronitro- imidazole in non-small-cell lung cancer.2007

    • Author(s)
      Yasuda H, Kaneta T, Takai Y, et al.
    • Journal Title

      J Am Geriatr Soc 55

      Pages: 1142-1144

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia.2007

    • Author(s)
      Kaneta T, Takai Y, Iwata R, Hakamatsuka T, Yasuda H, et al.
    • Journal Title

      Ann Nucl Med 21

      Pages: 101-107

    • NAID

      10018874948

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acid and swallowing reflex.2007

    • Author(s)
      Ebihara T, Ebihara S, Ohrui T, Yasuda H, et al.
    • Journal Title

      Geriatr Gerontol Int 7

      Pages: 94-95

    • NAID

      10019489828

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Partial response by nitroglycerin plus amrubicin regimen in patients with refractory and recurrent advanced non-small cell lung cancer who had received at least third-line chemotherapy: Case report.2007

    • Author(s)
      Yasuda H, Nakayama K, Sasaki T, et al.
    • Journal Title

      Cancer Therapy 5

      Pages: 451-456

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hochu-ekki-to inhibits rhinovirus infection in human tracheal epithelial cells.2007

    • Author(s)
      Yamaya M, Sasaki T, Yasuda H, et al.
    • Journal Title

      Brit J Pharmacol 150

      Pages: 702-710

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment and prevention of COPD exacerbation.2007

    • Author(s)
      Yamaya M, Yasuda H, Yoshida M, et al.
    • Journal Title

      Nippon Rinsho 65

      Pages: 734-739

    • NAID

      40015395576

    • Related Report
      2009 Final Research Report
  • [Journal Article] 進行非小細胞肺癌における抗癌剤とニトログリセリン併用療法の個別化医療への展望2007

    • Author(s)
      安田浩康、中山勝敏、山谷睦雄, ら
    • Journal Title

      分子呼吸器病特集肺癌:個別化医療への最先端研究 11

      Pages: 45-52

    • Related Report
      2009 Final Research Report
  • [Journal Article] 糖尿病合併肺炎の診療上の注意点2007

    • Author(s)
      安田浩康、中山勝敏、山谷睦雄
    • Journal Title

      診断と治療 95

      Pages: 81-84

    • Related Report
      2009 Final Research Report
  • [Journal Article] Partial response by nitroglycerin plus amrubicin regimen in patients with refractory and recurrent advanced non-small cell lung cancer who had received at least third-line chemotherapy2007

    • Author(s)
      Yasuda H, et. al.
    • Journal Title

      Cancer Therapy 5

      Pages: 451-456

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor hypoxia imaging with [F-18] fluoronitroimidazole in non-small-cell lung cancer.2007

    • Author(s)
      Yasuda H, et. al.
    • Journal Title

      J Am Geriatr Soc 55

      Pages: 1142-1144

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Initial evaluation of dynamic human imaging using 18F-FRP170 as a new PET tracer for imaging hypoxia.2007

    • Author(s)
      Kaneta T, et. al.
    • Journal Title

      Ann Nucl Med 21

      Pages: 101-1078

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肺高血圧症合併慢性閉塞性肺疾患症例に対する低濃度一酸化炭素吸入療法の効果2009

    • Author(s)
      安田浩康
    • Organizer
      第46回日本臨床生理学会総会
    • Place of Presentation
      岩手県盛岡市
    • Year and Date
      2009-11-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺高血圧症合併慢性閉塞性肺疾患症例に対する低濃度一酸化炭素吸入療法の効果.2009

    • Author(s)
      安田浩康
    • Organizer
      第46回日本臨床生理学会総会
    • Place of Presentation
      盛岡(ワークショップ)
    • Year and Date
      2009-10-20
    • Related Report
      2009 Final Research Report
  • [Presentation] The effects of low-dose inhaled carbon monoxide on the dyspnea in patients with chronic obstructive pulmonary disease.2009

    • Author(s)
      Yasuda H
    • Organizer
      14th World Congress on Advances in Oncology and 12th International Symposium on Molecular Medicine.
    • Place of Presentation
      Loutraki, Greece.
    • Year and Date
      2009-10-17
    • Related Report
      2009 Final Research Report
  • [Presentation] The effects of low-dose inhaled carbon monoxide on the dyspnea in patients with chronic obstructive pulmonary disease2009

    • Author(s)
      安田浩康
    • Organizer
      14^<th> World Congress on Advances in Oncology and 12^<th> International Symposium on Molecular Medicine
    • Place of Presentation
      Loutraki, Greece
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Novel strategy for cancer therapy with nitroglycerin as a NO donor.2009

    • Author(s)
      Yasuda H
    • Organizer
      First International Workshop on Nitric Oxide in Cancer Therapy.
    • Place of Presentation
      Dijon, France
    • Year and Date
      2009-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel strategy for cancer therapy with nitroglycerin as a NO donor2009

    • Author(s)
      安田浩康
    • Organizer
      International Workshop on Nitric Oxide in Cancer Therapy
    • Place of Presentation
      Dijon, France
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] PK/PD解析から見た抗がん剤の効果・副作用)固形がんに対する一酸化窒素供与剤併用化学療法.2009

    • Author(s)
      安田浩康
    • Organizer
      第17回クリニカルファーマシーシンポジウム医療薬学フォーラム2009
    • Place of Presentation
      京都(シンポジウム4)
    • Year and Date
      2009-07-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 固形がんに対する一酸化窒素供与剤併用化学療法2009

    • Author(s)
      安田浩康
    • Organizer
      第17回クリニカルファーマシーシンポジウム 医療薬学フォーラム2009
    • Place of Presentation
      京都府京都市
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 固形癌組織の生理学的特徴と新規治療戦略2009

    • Author(s)
      安田浩康
    • Organizer
      第1回信州肺癌セミナー
    • Place of Presentation
      長野県松本市
    • Year and Date
      2009-06-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibitory Effects of Nitroglycerin on Intratumor P-Glycoprotein and Phospholyrated Caveolin-1 in Lewis Lung Carcinoma Bearing Murine Model.2009

    • Author(s)
      Hatachi Y, Yasuda H, Nagai H, et al.
    • Organizer
      ATS 2009
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-05-19
    • Related Report
      2009 Final Research Report
  • [Presentation] P-glycoprotein (P-gp) May Be Associated with Chemoresistance to Amrubicin (AMR) in Lewis Lung Carcinoma (LLC)2009

    • Author(s)
      Yasuda H, Sasaki T, Asada M, et al.
    • Organizer
      ATS 2009
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-05-19
    • Related Report
      2009 Final Research Report
  • [Presentation] The effects of low-dose inhaled carbon monoxide (CO) on the dyspnea in patients with chronic obstructive pulmonary disease (COPD).2009

    • Author(s)
      Sasaki T, Yasuda H, Nakayama K, et al.
    • Organizer
      ATS 2009
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2009-05-19
    • Related Report
      2009 Final Research Report
  • [Presentation] Solid tumor physiology and hypoxia-induced chemo/radio-resistance: Novel strategy for cancer therapy: Nitric oxide donor as a therapeutic enhancer.2009

    • Author(s)
      安田浩康
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡(シンポジウム)
    • Year and Date
      2009-05-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Solid tumor physiology and hypoxia-induced chemo/radio-resistance : Novel strategy for cancer therapy : Nitric oxide donor as a therapeutic enhancer2009

    • Author(s)
      安田浩康
    • Organizer
      第9回日本NO学会学術集会
    • Place of Presentation
      静岡県静岡市
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibitory Effects of Nitroglycerin on Intratumor P-Glycoprotein and Phospholyrated Caveolin-1 in Lewis Lung Carcinoma Bearing Murine Model2009

    • Author(s)
      Hatachi Y, Yasuda H, Nagai H, et al.
    • Organizer
      ATS 2009
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2009-04-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] P-glycoprotein May Be Associated with Chemoresistance to Amrubicin in Lewis Lung Carcinoma Cells2009

    • Author(s)
      Yasuda H, Sasaki T, Asada M, et al.
    • Organizer
      ATS 2009
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2009-04-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] The effects of low-dose inhaled carbon monoxide on the dyspnea in patients with chronic obstructive pulmonary disease2009

    • Author(s)
      Sasaki T, Yasuda H, Nakayama K, et al.
    • Organizer
      ATS 2009
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Glyceryl Trinitrate may enhance chemosensitivity to cisplatin and docetaxel via inhibitions of Akt signaling pathway and HIF-1 pathway and via activation of p53 in murine syngraft solid cancer model.2008

    • Author(s)
      Yasuda H
    • Organizer
      13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine.
    • Place of Presentation
      Crete, Greece
    • Year and Date
      2008-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] INHIBITORY EFFECTS OF NITROGLYCERIN ON INTRATUMOR P-GLYCOPROTEIN AND PHOSPHOLYRATED CAVEOLIN-1 IN LEWIS LUNG CARCINOMA BEARING MURINE MODEL.2008

    • Author(s)
      Hatachi Y, Nagai H, Mio T, Mishima M, Yasuda H
    • Organizer
      13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine.
    • Place of Presentation
      Crete, Greece
    • Year and Date
      2008-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] PHASE II STUDY OF COMBINATION CHEMOTHERAPY WITH S-1 PLUS DOCETAXEL FOR PREVIOUSLY TREATED PATIENTS WITH NON-SMALL-CELL LUNG CANCER IN A SECOND OR THIRD LINE REGIMEN.2008

    • Author(s)
      Yanagihara K, Yasuda H, Niimi M, et al.
    • Organizer
      ESMO 2008
    • Place of Presentation
      Stockholm, Sweeden
    • Year and Date
      2008-09-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Nitroglycerin may increase response to docetaxel and cisplatin in murine syngraft solid cancer models via reduction of HIF-1α, P-gp, and phosphorylated Akt and via increase in activated p53 in tumor tissues2008

    • Author(s)
      Yasuda H, Katsutoshi Nakayama, et al.
    • Organizer
      AACR 2008
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2008-04-14
    • Related Report
      2009 Final Research Report
  • [Presentation] Glyceryl Trinitrate may enhance chemosensitivity to cisplatin and docetaxel via inhibitions of Akt signaling pathway and HIF-1 pathway and via activation of p53 in murine syngraft solid cancer model2008

    • Author(s)
      Yasuda H, et.al.
    • Organizer
      13^<th>World Congress on Advances in Oncology and 11^<th>International Symposium on Molecular Medicine
    • Place of Presentation
      Creta Maris Hersonissos, Crete, Greece
    • Related Report
      2008 Annual Research Report
  • [Presentation] Concomitant use of nitroglycerin with anticancer agents in solid cancer.2007

    • Author(s)
      Yasuda H
    • Organizer
      1st International Conference on Nitric Oxide and Cancer.
    • Place of Presentation
      Paris, France
    • Year and Date
      2007-11-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Concomitant use of nitroglycerin with anticancer agents in solid cancer.2007

    • Author(s)
      Yasuda H, et. al.
    • Organizer
      1st NO and Cancer International Conference
    • Place of Presentation
      Paris, France
    • Year and Date
      2007-11-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] Nitroglycerin treatment may increase response to docetaxel and carboplatin regimen via inhibitions of hypoxia-inducible factor-1 pathway and P-glycoprotein in patients with lung adenocarcinoma.2007

    • Author(s)
      Yasuda H
    • Organizer
      12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine.
    • Place of Presentation
      Crete, Greece
    • Year and Date
      2007-10-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 肺線癌症例におけるニトログリセリン使用による腫瘍内HIF-1 pathwayの抑制効果2007

    • Author(s)
      安田浩康、中山勝敏、浅田成紀, ら
    • Organizer
      第5回日本臨床腫瘍学会
    • Place of Presentation
      札幌(プレナリーセッションII)
    • Year and Date
      2007-08-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of a novel information technology (IT) system using the electronic medical record (EMR) in daily clinical practice2007

    • Author(s)
      Matsumoto S, Nishimura T, Kanai M, Ishiguro H, Yasuda H, et al.
    • Organizer
      ASCO 2007
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2007-06-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Carbocisteine, a mucolytic drug, prevents apoptosis in a human airway mucoepidermoid cell line induced by oxidative stress2007

    • Author(s)
      Yoshida M, Yasuda H, Nakayama K, et al.
    • Organizer
      ATS 2007
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Hochu-ekki-to, a traditional Japanese herbal medicine, inhibits rhinovirus infection in human tracheal epithelial cells2007

    • Author(s)
      Nakayama K, Sasaki T, Yasuda H, et al.
    • Organizer
      ATS 2007
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Nitroglycerin treatment may increase response to docetaxel and carboplatin regimen via inhibitions of hypoxia-inducible factor-1 pathway and p-glycoprotein in patients with lung adenocarcinoma2007

    • Author(s)
      Yasuda H, Nakayama K, Watanabe M, et al.
    • Organizer
      ATS 2007
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Pleurodesis with carboplatin in elderly patients with malignant pleural effusion and lung adenocarcinoma2007

    • Author(s)
      Sasaki T, Yasuda H, Nakayama K, et al.
    • Organizer
      ATS 2007
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-23
    • Related Report
      2009 Final Research Report
  • [Presentation] Interleukin-1beta gene polymorphisms associated with risk of lung cancwe in Japanese2007

    • Author(s)
      Asada M, Yasuda H, Ebihara S, et al.
    • Organizer
      ATS 2007
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2007-05-23
    • Related Report
      2009 Final Research Report
  • [Book] Nitric Oxide and Cancer : Prognosis and Therapy2010

    • Author(s)
      Yasuda H, Bonavida B
    • Publisher
      Springer(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.cancer.gov/clinicaltrials/TRIC-TRIL-C0702

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      https://center.umin.ac.jp/cgi-bin/ctr/ctr.cgi?function=brows&action=brows&type=detail&recptno=R000000973&admin=0&language=J

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      https://center.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000002194&language=J

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.cancer.gov/clinicaltrials/TRIC-TRIL-C0702

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      https://center.umin.ac.jp/cgi-bin/ctr/ctr.cgi?function=brows&action=brows&type=detail&recptno=R000000973&admin=0&language=J

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      https://center.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000002194&language=J

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://clinicaltrials.gov/ct2/show/NCT00616031?intr=%22Nitroglycerin%22&rank=10

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      https://ce.nter.umin.ac.jp/cgiopenbin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000002194&language=J

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://clinicaltrials.gov/ct2/show/NCT00616031?intr=%22Nitroglycerin%22&rank=10

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 肺疾患の治療に用いられる気体製剤及びそれを用いた吸入療法2010

    • Inventor(s)
      安田浩康、佐々木陽彦、中山勝敏、海老原覚、山谷睦雄、福島雅典
    • Industrial Property Rights Holder
      東北大学、フクダ電子
    • Industrial Property Number
      2009-117078
    • Filing Date
      2010-05-13
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] 肺疾患の治療に用いられる気体製剤及びそれを用いた吸入療法2009

    • Inventor(s)
      安田浩康、佐々木陽彦、中山勝敏、海老原覚、山谷睦雄、福島雅典
    • Industrial Property Rights Holder
      東北大学、フクダ電子株式会社
    • Industrial Property Number
      2009-117078
    • Filing Date
      2009-05-13
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 気体製剤、及び低濃度一酸化炭素を用いた吸入療法2008

    • Inventor(s)
      安田浩康
    • Industrial Property Rights Holder
      安田浩康
    • Industrial Property Number
      2008-205312
    • Filing Date
      2008-08-08
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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