Analysis of the roles Th17 subset plays in inflammatory diseases, especially collagen diseases
| Project/Area Number |
19689021
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Saitama Medical University |
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Principal Investigator |
SATO Kojiro Saitama Medical University, 医学部, 講師 (10372434)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2008: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | Th17 / c-Maf / トランスクリプトーム / メモリー / IL-17 / IL-23受容体 / 炎症 / サイトカイン / T細胞 / 膠原病 / 自己免疫疾患 / メモリーT細胞 / Th1 / 2 |
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| Research Abstract |
We performed a transcriptome analysis of Th1, Th2 and Th17 cells differentiated in vitro and discovered that transcription factor c-Maf is strongly induced in the course of Th17 differentiation. We also analyzed c-Maf transgenic mice and unexpectedly found that most Th cells had memory phenotype. It is suggested that c-Maf plays an important role not only in Th17 but also in memory Th differentiation.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Analysis of cytokine production patterns of peripheral blood mononuclear cells from a rheumatoid arthritis patient successfully treated with rituximab.2010
Author(s)
Yamamoto A, Sato K, Miyoshi F, Shindo Y, Yoshida Y, Yokota K, Nakajima K, Akiba H, Asanuma Y, Akiyama Y, Mimura T.
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Journal Title
Mod Rheumatol. 20(2)
Pages: 183-187
NAID
Related Report
Peer Reviewed
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