Analysis of the roles Th17 subset plays in inflammatory diseases, especially collagen diseases

• Project/Area Number: 19689021
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Saitama Medical University
• Principal Investigator: SATO Kojiro Saitama Medical University, 医学部, 講師 (10372434)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000); Fiscal Year 2009: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2008: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2007: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: Th17 / c-Maf / トランスクリプトーム / メモリー / IL-17 / IL-23受容体 / 炎症 / サイトカイン / T細胞 / 膠原病 / 自己免疫疾患 / メモリーT細胞 / Th1 / 2

Research Abstract

We performed a transcriptome analysis of Th1, Th2 and Th17 cells differentiated in vitro and discovered that transcription factor c-Maf is strongly induced in the course of Th17 differentiation. We also analyzed c-Maf transgenic mice and unexpectedly found that most Th cells had memory phenotype. It is suggested that c-Maf plays an important role not only in Th17 but also in memory Th differentiation.

Research Products

• [Journal Article] Marked Induction of c-Maf Protein during Th17 Cell Differentiation and Its Implication in Memory Th Cell Development. (2011)
  • Author(s): Sato K, Miyoshi F, Yokota K, Araki Y, Asanuma Y, Akiyama Y, Yoh K, Takahashi S, Aburatani H, Mimura T.
  • Journal Title: J Biol Chem. 286(17) Pages: 14963-14971
  • Peer Reviewed
• [Journal Article] Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. (2011)
  • Author(s): Yokota K, Miyoshi F, Sato K, Asanuma Y, Akiyama
  • Journal Title: Clin Exp Rheumatol. 29(1) Pages: 43-49
  • Peer Reviewed
• [Journal Article] Marked induction of c-Maf protein during Th17 cell differentiation and its implication in memory Th cell development. (2011)
  • Author(s): Sato Kojiro
  • Journal Title: J Biol Chem. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. (2011)
  • Author(s): Yokota Kazuhiro
  • Journal Title: Clin Exp Rheumatol. Volume: 29 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Analysis of cytokine production patterns of peripheral blood mononuclear cells from a rheumatoid arthritis patient successfully treated with rituximab. (2010)
  • Author(s): Yamamoto A, Sato K, Miyoshi F, Shindo Y, Yoshida Y, Yokota K, Nakajima K, Akiba H, Asanuma Y, Akiyama Y, Mimura T.
  • Journal Title: Mod Rheumatol. 20(2) Pages: 183-187
  • NAID: 10027169015
  • Peer Reviewed
• [Journal Article] Analysis of cytokine production patterns of peripheral blood mononuclear cells from a rheumatoid arthritis patient successfully treated with rituximab. (2010)
  • Author(s): Yamamoto Akinori
  • Journal Title: Mod Rheumatol. Volume: 20 Pages: 183-187
  • Peer Reviewed
• [Journal Article] Th17 cells and rheumatoid arthritis--from the standpoint of osteoclast differentiation--. (2008)
  • Author(s): Sato K.
  • Journal Title: Allergol Int. 57(2) Review Pages: 109-114
  • NAID: 10021246267
• [Journal Article] High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis. (2008)
  • Author(s): Yokota K, Miyoshi F, Miyazaki T, Sato K, Yoshida Y, Asanuma Y, Akiyama Y, Mimura T.
  • Journal Title: J Rheumatol. 35(2) Pages: 193-200
  • Peer Reviewed
• [Journal Article] The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells. (2008)
  • Author(s): Kano S, Sato K, Morishita Y, Vollstedt S, Kim S, Bishop K, Honda K, Kubo M, Taniguchi T.
  • Journal Title: Nat Immunol. 9(1) Pages: 34-41
  • Peer Reviewed
• [Journal Article] Th17 cells and rheumatoid arthritis--from the standpoint of osteoclast differentiation (2008)
  • Author(s): Sato Kojiro
  • Journal Title: Allergology Internationalt 57 Pages: 109-114
  • NAID: 10021246267
• [Journal Article] The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells. (2008)
  • Author(s): Kano Shin-ichi
  • Journal Title: Nat Immunol. 9 Pages: 34-41
  • Peer Reviewed
• [Journal Article] High concentration simvastatin induces apoptosis in fibroblast-like synoviocytes from patients with rheumatoid arthritis. (2008)
  • Author(s): Yokota Kazuhiro
  • Journal Title: J Rheumatol. 35 Pages: 193-200
  • Peer Reviewed
• [Journal Article] Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios. (2007)
  • Author(s): Kanda H, Yokota K, Kohno C, Sawada T, Sato K, Yamaguchi M, Komagata Y, Shimada K, Yamamoto K, Mimura T.
  • Journal Title: Mod Rheumatol. 17(5) Pages: 364-368
  • NAID: 10019778047
  • Peer Reviewed
• [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss. (2007)
  • Author(s): Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H.
  • Journal Title: Proc Natl Acad Sci U S A. 104(27) Pages: 11394-11399
  • Peer Reviewed
• [Journal Article] Pathological role of osteoclast costimulation in arthritis-induced bone loss. (2007)
  • Author(s): Ochi Sae
  • Journal Title: Proc Natl Acad Sci U S A. 104 Pages: 11394-9
  • Peer Reviewed
• [Journal Article] Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios. (2007)
  • Author(s): Kanda Hiroko
  • Journal Title: Mod Rheumatol. 17 Pages: 364-8
  • Peer Reviewed
• [Presentation] THE TRANSCRIPTION FACTOR C-MAF PLAYS CRITICAL ROLES IN THE DIFFERENTIATION OF T HELPER CELLS (2010)
  • Author(s): Sato Kojiro
  • Organizer: Eular 2010
  • Place of Presentation: Rome
  • Year and Date: 2010-06-18
• [Presentation] The transcription factor c-Maf plays critical roles in the differentiation of T helper cells (2010)
  • Author(s): 佐藤浩二郎
  • Organizer: EULAR 2010
  • Place of Presentation: Rome
  • Year and Date: 2010-06-18
• [Presentation] 転写因子c-MafがTh細胞分化において 果たす役割の解析 (2010)
  • Author(s): 佐藤浩二郎
  • Organizer: 第54回日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-04-23
• [Presentation] 転写因子c-MafがTh細胞分化において果たす役割の解析 (2010)
  • Author(s): 佐藤浩二郎
  • Organizer: 第54回 日本リウマチ学会総会・学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2010-04-23
• [Presentation] メモリーTh17細胞において転写因子c-Mafが果たす役割の解析 (2009)
  • Author(s): 佐藤浩二郎
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] The role transcription factor c-Maf plays in memory Th17 cells. (2009)
  • Author(s): 佐藤浩二郎
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-02
• [Presentation] Proto-oncogene Maf plays an important role in Th17-cell differentiation Keystone (2009)
  • Author(s): Sato Kojiro
  • Organizer: Symposium : TH17 Cells in Health and Disease
  • Place of Presentation: Vancouver
  • Year and Date: 2009-02-07
• [Presentation] Proto-oncogene Maf plays an important role in Th17-cell differentiation (2009)
  • Author(s): Sato Kojiro
  • Organizer: Keystone Symposium TH17 cells in Health and Disease
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2009-02-07
• [Presentation] 転写因子c-MafはTh17分化において重要な役割を果たす (2008)
  • Author(s): 佐藤浩二郎
  • Organizer: 第38回日本免疫学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 転写因子c-MafはTh17発化において重要な役割を果たす (2008)
  • Author(s): 佐藤浩二郎
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Transcriptome Analysis During Th1/2/17 Differentiation with an Aim to Understand the Th17 Differentiation Transcription Factor Network (2008)
  • Author(s): Sato Kojiro
  • Organizer: EULAR (European League Against Rheumatism) 2009
  • Place of Presentation: Paris, France
  • Year and Date: 2008-06-12
• [Presentation] TRANSCRIPTOME ANALYSIS DURING TH1/2/17 DIFFERENTIATION WITH AN 3解析及びマウスTh17細胞のトランスクリプトーム解析 (2007)
  • Author(s): Sato Kojiro
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Presentation] 膠原病患者由来単核球のサイトカインプロファイル解析及びマウスTh17細胞のトランスクリプトーム解析 (2007)
  • Author(s): 佐藤浩二郎
  • Organizer: 第37回日本免疫学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
• [Remarks] ホームページ等
  • URL: http://www.saitama-med.ac.jp/uinfo/riumachi/index.html
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  • URL: http://www.saitama-med.ac.jp/uinfo/riumachi/index.html
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• [Patent(Industrial Property Rights)] 膠原病診断方法 (2007)
  • Inventor(s): 佐藤浩二郎、三由文彦、三村俊英
  • Industrial Property Rights Holder: 学校法人 埼玉医科大学
  • Filing Date: 2007-08-29