Cutaneous immune responses to foreign stimuli

• Project/Area Number: 19689024
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Kyoto University (2008-2009); University of Occupational and Environmental Health, Japan (2007)
• Principal Investigator: KABASHIMA Kenji Kyoto University, 医学研究科, 准教授 (00362484)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000); Fiscal Year 2009: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2008: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2007: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
• Keywords: 皮膚 / 免疫 / 樹状細胞 / T細胞サブセット / 皮膚免疫 / 制御性T細胞 / 外的刺激 / ケモカイン / 脂質メディエーター / データベース

Research Abstract

Skin is one of the immune organs to defense against foreign stimuli. In the skin, there occur a wide variety of immune responses, such as contact dermatitis, atopic dermatitis, etc.To address the underlying mechanisms, we have revealed the roles of keratinocytes,dendritic cells, and T cells in cutaneous immune responses. In addition, we have revealedthe possibility of crosstalk between the skin immunity and the systemic immunity.

Research Products

• [Journal Article] Compensatory role of Langerhans cells and langerin-positive dermal dendritic cells in the sensitization phase of murine contact hypersensitivity. (2010)
  • Author(s): Honda T, Nakajima S, Egawa G, Ogasawara K, Malissen B, Miyachi Y, Kabashima K.
  • Journal Title: J Allergy Clin Immunol (in press)
  • Peer Reviewed
• [Journal Article] The Role of Regulatory T Cells in Contact Hypersensitivity. (2010)
  • Author(s): Honda T, Miyachi Y, Kabashima K.
  • Journal Title: Recent Pat Inflamm Allergy Drug Discov (in press)
  • Peer Reviewed
• [Journal Article] Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. (2010)
  • Author(s): Tomura M, Honda T, Tanizaki H, Otsuka A, Egawa G, Tokura Y, Waldmann H, Hori S, Cyster JG, Watanabe T, Miyachi Y, Kanagawa O, Kabashima K.
  • Journal Title: J Clin Invest 120 Pages: 883-93
  • Peer Reviewed
• [Journal Article] Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival. (2010)
  • Author(s): Sugita K, Kabashima K, Yoshiki R, Ikenouchi-Sugita A, Tsutsui M, Nakamura J, Yanagihara N, Tokura Y.
  • Journal Title: J Invest Dermatol 130 Pages: 464-71
  • Peer Reviewed
• [Journal Article] KIT Masters Mast Cells in Kids, Too. (2010)
  • Author(s): Kambe N, Longley BJ, Miyachi Y, Kabashima K.
  • Journal Title: J Invest Dermatol 130 Pages: 648-50
  • Peer Reviewed
• [Journal Article] Involvement of Wnt signaling in dermal fibroblasts. (2010)
  • Author(s): Kabashima K, Sakabe J, Yoshiki R, Tabata Y, Kohno K, Tokura Y.
  • Journal Title: Am J Pathol 176 Pages: 721-32
  • Peer Reviewed
• [Journal Article] Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE-high extrinsic and IgE-normal intrinsic types of atopic dermatitis. (2010)
  • Author(s): Mori T, Ishida K, Mukumoto S, Yamada Y, Imokawa G, Kabashima K, Kobayashi M, Bito T, Nakamura M, Ogasawara K, Tokura Y.
  • Journal Title: Br J Dermatol 162(1) Pages: 83-90
  • Peer Reviewed
• [Journal Article] Activated regulatory T cells are major T cell type emigrating from sensitized skin. (2010)
  • Author(s): Tomura M, Honda T, (他10名), Kabashima K
  • Journal Title: J Clin Invest 120(3) Pages: 883-893
  • Peer Reviewed
• [Journal Article] Compensatory role of Langerhans cells and Langerin-positive dermal dendritic cells in the sensitization phase of mouse contact hypersensitivity. (2010)
  • Author(s): Honda T, Nakajima S, Egawa G, Ogasawara K, Malissen B, Miyachi Y, Kabashima K
  • Journal Title: J Allergy Clin Immunol 125(5) Pages: 1154-1156
  • Peer Reviewed
• [Journal Article] Flaky tail mouse as a possible model of atopic dermatitis. (2010)
  • Author(s): Moniaga CS, Egawa G, (他12名), Kabashima K
  • Journal Title: Am J Pathol (in press)
  • Peer Reviewed
• [Journal Article] Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity. (2010)
  • Author(s): Honda T, Matsuoka T, Ueta M, Kabashima K, Miyachi Y, Narumiya S.
  • Journal Title: J Allergy Clin Immunol (in press)
  • Peer Reviewed
• [Journal Article] Inducible Nitric Oxide Synthase Downmodulates Contact Hypersensitivity by Suppressing Dendritic Cell Migration and Survival. (2010)
  • Author(s): Sugita, K., Kabashima, K., Yoshiki, R., Ikenouchi-Sugita, A., Tsutsui, M., Nakamura, J., Yanagihara, N., Tokura, Y.
  • Journal Title: J Invest Dermatol (in press)
  • Peer Reviewed
• [Journal Article] IL-10-producing Langerhans cells and regulatory T cells are responsible for depressed contact hypersensitivity in grafted skin. (2009)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T, Tokura Y.
  • Journal Title: J Invest Dermatol 129 Pages: 705-13
  • Peer Reviewed
• [Journal Article] Induction of eosinophil- and Th2-attracting epidermal chemokines and cutaneous late-phase reaction in tape-stripped skin. (2009)
  • Author(s): Onoue A, Kabashima K, Kobayashi M, Mori T, Tokura Y.
  • Journal Title: Exp Dermatol 18(12) Pages: 1036-43
  • Peer Reviewed
• [Journal Article] Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity. (2009)
  • Author(s): Honda T, Matsuoka T, Ueta M, Kabashima K, Miyachi Y, Narumiya S.
  • Journal Title: J Allergy Clin Immunol 124
  • Peer Reviewed
• [Journal Article] IL-10-Producing Langerhans Cells and Regulatory T Cells Are Responsible for Depressed Contact Hypersensitivity in Grafted Skin. (2009)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T, Tokura Y.
  • Journal Title: J Invest Dermatol 129(3) Pages: 705-713
  • Peer Reviewed
• [Journal Article] IL-10-Producing Langerhans Cells and Regulatory T Cells Are Responsible for Depressed Contact Hypersensitivity in Grafted Skin (2009)
  • Author(s): Yoshiki R, Kabashima K, Sugita K, Atarashi K, Shimauchi T, Tokura Y
  • Journal Title: J Invest Dermatol 129(3) Pages: 705-13
  • Peer Reviewed
• [Journal Article] Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals. (2008)
  • Author(s): Tokura Y, Kobayashi M, Kabashima K.
  • Journal Title: Exp Dermatol 17 Pages: 81-90
  • Peer Reviewed
• [Journal Article] Impaired initiation of contact hypersensitivity by FTY720. (2008)
  • Author(s): Nakashima D, Kabashima K, Sakabe J, Sugita K, Kobayashi T, Yoshiki R, Tokura Y.
  • Journal Title: J Invest Dermatol 128 Pages: 2833-41
  • Peer Reviewed
• [Journal Article] Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines. (2008)
  • Author(s): Mori T, Kabashima K, Yoshiki R, Sugita K, Shiraishi N, Onoue A, Kuroda E, Kobayashi M, Yamashita U, Tokura Y.
  • Journal Title: J Invest Dermatol 128 Pages: 1719-27
  • Peer Reviewed
• [Journal Article] Possible pathogenic role of Th17 cells for atopic dermatitis. (2008)
  • Author(s): Koga C, Kabashima K, Shiraishi N, Kobayashi M, Tokura Y.
  • Journal Title: J Invest Dermatol 128 Pages: 2625-30
  • Peer Reviewed
• [Journal Article] Impaired initiation of contact hypersensitivity by FTY720 (2008)
  • Author(s): 11. Nakashima D, Kabashima K, Sakabe J, Sugita K, Kobayashi T, Yoshiki R, et.al.
  • Journal Title: J Invest Dermatol 128 Pages: 2833-41
  • Peer Reviewed
• [Journal Article] Possible pathogenic role of Th17 cells for atopic dermatitis (2008)
  • Author(s): Koga C, Kabashima K, Shiraishi N, Kobayashi M. Tokura Y
  • Journal Title: J Invest Dermatol 128 Pages: 2625-30
  • Peer Reviewed
• [Journal Article] Percutaneous penetration via hand eczema is the major accelerating factor for systemic absorption of toluene and xylene during car spray painting (2008)
  • Author(s): 23. Hino R, Nishio D, Kabashima K, Tokura Y
  • Journal Title: Contact Dermatitis 58 Pages: 76-79
  • Peer Reviewed
• [Journal Article] Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. (2007)
  • Author(s): Nagamachi M, Sakata D, Kabashima K, Furuyashiki T, Murata T, Segi-Nishida E, Soontrapa K, Matsuoka T, Miyachi Y, Narumiya S.
  • Journal Title: J Exp Med 204 Pages: 2865-74
  • Peer Reviewed
• [Journal Article] CXCR4 engagement promotes dendritic cell survival and maturation. (2007)
  • Author(s): Kabashima K, Sugita K, Shiraishi N, Tamamura H, Fujii N, Tokura Y.
  • Journal Title: Biochem Biophys Res Commun 361 Pages: 1012-6
  • Peer Reviewed
• [Journal Article] CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. (2007)
  • Author(s): Kabashima K, Shiraishi N, Sugita K, Mori T, Onoue A, Kobayashi M, Sakabe J, Yoshiki R, Tamamura H, Fujii N, Inaba K, Tokura Y.
  • Journal Title: Am J Pathol 171 Pages: 1249-57
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors. (2007)
  • Author(s): Kabashima K, Nagamachi M, Honda T, Nishigori C, Miyachi Y, Tokura Y, Narumiya S.
  • Journal Title: Lab Invest 87 Pages: 49-55
  • Peer Reviewed
• [Journal Article] CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells. (2007)
  • Author(s): Kabashima K, et, al.
  • Journal Title: Am J Pathol 171 Pages: 1249-57
  • Peer Reviewed
• [Journal Article] CXCR4 engagement promotes dendritic cell survival and maturation. (2007)
  • Author(s): Kabashima K, et, al.
  • Journal Title: Biochem Biophys Res Commun 361 Pages: 1012-6
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 is required for ultraviolet B-induced skin inflammation via EP2 and EP4 receptors. (2007)
  • Author(s): Kabashima K, et, al.
  • Journal Title: Lab Invest 87 Pages: 49-55
  • Peer Reviewed
• [Presentation] Actin cytoskeleton formation through mDial is essential for DC-T cell interaction and T cell motility in the lymph nodes」 (2009)
  • Author(s): 椛島健治
  • Organizer: 日本免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-03
• [Presentation] 接触皮膚炎における樹状細胞の最新知見」 (2009)
  • Author(s): 椛島健治
  • Organizer: 臨床免疫学会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-13
• [Presentation] What's new in immunology of metal allergy (2009)
  • Author(s): Kenji Kabashima
  • Organizer: 17^<th> International Contact Dermatitis Symposium 2009
  • Place of Presentation: Kyoto
  • Year and Date: 2009-11-06
• [Presentation] 「Th17とアトピー性皮膚炎」(シンポジウム) (2008)
  • Author(s): 椛島健治
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] 表皮細胞とフィラグリン (2008)
  • Author(s): 椛島健治
  • Organizer: 日本アレルギー学会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-28
• [Presentation] Langerhans cells and prostaglandins: contribution to the etiology and pathogenesis of atopic dermatitis and related disorders (symposium) (2008)
  • Author(s): Kabashima K.
  • Organizer: 5th Georg Rajka International Symposium on Atopic Dermatitis
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-05-12
• [Presentation] Langerhans cells and prostaglandins : contribution to the etiology and pathogenesis of atopic dermatitis and related disorders (symposium) (2008)
  • Author(s): Kabashima K
  • Organizer: 5th Georg Rajka International Symposium on Atopic Dermatitis
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2008-05-12
• [Presentation] 皮膚アレルギーの新しい知見と臨床応用の可能性について (2008)
  • Author(s): 椛島健治
  • Organizer: 第38回日本皮膚アレルギー・接触皮膚炎学術大会
  • Place of Presentation: 大阪
• [Presentation] IL-17とTh2型免疫応答 (2008)
  • Author(s): 椛島健治
  • Organizer: シンポジウム第38回日本皮膚アレルギー・接触皮膚炎学術大会
  • Place of Presentation: 大阪
• [Presentation] 接触皮膚炎と樹状細胞 (2008)
  • Author(s): 椛島健治
  • Organizer: 第3 46回日本皮膚科学会
  • Place of Presentation: 福岡地方会北九州
• [Presentation] Possible pathogenic role of Th17 cells for atopic dermatitis. (2008)
  • Author(s): C Koga, K Kabashima, N Shiraishi, M Kobayashi, Y Tokura
  • Organizer: IID 2008
  • Place of Presentation: Kyoto, Japan
• [Presentation] CXCL12-CXCR4 engagement is required for migration and survival of cutaneous dendritic cells. (2007)
  • Author(s): Kabashima K, et. al.
  • Organizer: Society for Investigative Dermatology Annual Meeting
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2007-05-10
• [Presentation] CLCL12-CXCR4 engagement is required for migration and survival of cutaneous dendritic cells (2007)
  • Author(s): Kabashima K, et, al.
  • Organizer: Society for Investigative Dermatology Annual Meeting
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2007-05-10
• [Presentation] Lipid mediators and the skin (2007)
  • Author(s): Kabashima K, et, al.
  • Organizer: 1st annual symposium at the Institute of Dermatological Science
  • Place of Presentation: Seoul, Krea
  • Year and Date: 2007-02-09
• [Book] 古川福美皮膚科疾患診療実践ガイド (2009)
  • Author(s): 椛島健治
  • Publisher: 文光堂
• [Book] 紫外線と表皮角化細胞 (2008)
  • Author(s): 椛島健治
  • Publisher: 文光堂
• [Book] 北原光夫今日の治療指針2009 (2008)
  • Author(s): 椛島健治
  • Publisher: 医学書院
• [Book] 文光堂外的刺激が起こす皮膚の免疫反応. 皮膚科診療プラクティス2 0 Environmental Dermatology (2007)
  • Author(s): 椛島健治
  • Publisher: 文光堂
• [Book] 外的刺激が起こす皮膚の免疫反応.皮膚科診療プラクティス20Environmental Dermatology (2007)
  • Author(s): 椛島健治
  • Total Pages: 6
  • Publisher: 文光堂
• [Book] 一冊でわかる光皮膚科「紫外線と表皮角化細胞」
  • Author(s): 椛島健治
  • Publisher: 文光堂東京
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~skin/index.html
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~skin/index.html
• [Remarks]
  • URL: http://www.uoeh-u.ac.jp/kouza/hifuka/intro_j.html
• [Patent(Industrial Property Rights)] GAMMA/DELTA REGULATORY T CELLS (2009)
  • Inventor(s): 椛島健治、大塚篤司
  • Industrial Property Rights Holder: 椛島健治、大塚篤司
  • Filing Date: 2009-07-27
• [Patent(Industrial Property Rights)] 皮膚バリア機能の測定方法 (2009)
  • Inventor(s): 椛島健治、竹馬真理子、Catharina Moniaga
  • Industrial Property Rights Holder: 椛島健治、竹馬真理子、Catharina Moniaga
  • Acquisition Date: 2009-08-26
• [Patent(Industrial Property Rights)] EP4アゴニストを含有してなる細胞傷害性T細胞の活性化剤 (2008)
  • Inventor(s): 瀧川雅浩、椛島健治、瀬尾尚宏
  • Industrial Property Rights Holder: 瀧川雅浩、椛島健治、瀬尾尚宏
  • Acquisition Date: 2008-05-07