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Translational research of ocular circulation for new treatment of diabetic retinopathy

Research Project

Project/Area Number 19689035
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionAsahikawa Medical College

Principal Investigator

NAGAOKA Taiji  Asahikawa Medical College, 医学部, 講師 (00333691)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2007: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords糖尿病網膜症 / 微小循環 / 血管内皮機能 / トランスレーショナルリサーチ / 一酸化窒素
Research Abstract

眼循環のトランスレーショナルリサーチを実践すべく基礎および臨床研究を行った。まず、旭川医科大学にブタ摘出血管を用いたin vitro実験系を国内で初めて構築し、網膜血管への薬物の直接作用とメカニズムについて検討した。また、ネコを用いたin vivo生体実験系では、非侵襲的に網膜血管内皮機能を評価できる可能性を示した。臨床研究では、2型糖尿病患者の眼循環動態についての詳しい検討を行った。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2008 2007 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (12 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Effect of Panretinal Photocoagulation on Choroidal Circulation in the Foveal Region in Patients with Severe Diabetic Retinopathy2008

    • Author(s)
      Takahashi A, Nagaoka T, Sato E, Yoshida A
    • Journal Title

      Br J Ophthalmol 92

      Pages: 1369-73

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of Nitric Oxide in Regulation of Retinal Blood Flow in Response to Hyperoxia in Cats2008

    • Author(s)
      Izumi N, Nagaoka T, Sato E, Sogawa K, Kagokawa H, Takahashi A, Kawahara A, Yoshida A
    • Journal Title

      Invest Ophthalmol Vis Sci. 49

      Pages: 4595-603

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short-term effects of topical tafluprost on retinal blood flow in cats2008

    • Author(s)
      Izumi N, Nagaoka T, Sato E, Mori F, Takahashi A, Sogawa K, Yoshida A
    • Journal Title

      Journal of Ocular Pharmacology & Therapeutics 24(5)

      Pages: 521-526

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of prorenin in the pathogenesis of retinal neovascularization2008

    • Author(s)
      Yokota H, Takamiya A, Nagaoka T, Hikichi T, Ishida Y, Suzuki F, Yoshida A
    • Journal Title

      Hokkaido Igaku Zasshi 83(3)

      Pages: 159-65

    • NAID

      10029922738

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] C-Reactive Protein Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Retinal Arterioles via Enhanced Superoxide Production2008

    • Author(s)
      Nagaoka T, Kuo L, Yoshida A, Hein T
    • Journal Title

      Invest Ophthalmol Vis Sci 49

      Pages: 2053-60

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Panretinal Photocoagulation on Choroidal Circulation in the Foveal Region in Patients with Severe Diabetic Retinopathy2008

    • Author(s)
      Takahashi A, Nagaoka T, Sato E, Yoshida A.
    • Journal Title

      British Journal of Ophthalmology 92

      Pages: 1369-1373

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Nitric Oxide in Regulation of Retinal Blood Flow in Response to Hvneroxia in Cats2008

    • Author(s)
      Izumi N, Nagaoka T, Sato E, et.al.
    • Journal Title

      Investigative Ophthalmollogy & Visual Science 49

      Pages: 4595-4603

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term effects of topical tafluprost on retinal blood flow in cats2008

    • Author(s)
      Izumi N, Nagaoka T, Sato E, et.al.
    • Journal Title

      Journal of OcuIar Pharmacology & Therapeutics 24

      Pages: 521-526

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] C-Reactive Protein Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Retinal Arterioles via Enhanced Suneroxide Production2008

    • Author(s)
      Nagaoka T, Kuo L, Yoshida A et.al.
    • Journal Title

      Investigative Ophthalmollogy & Visual Science 49

      Pages: 2053-2060

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of prorenin in the pathogenesis of retinal neovascularization2008

    • Author(s)
      Yokota H, Takamiya A, Nagaoka T
    • Journal Title

      Hokkaido Igaku Zasshi 83

      Pages: 159-165

    • NAID

      10029922738

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol, a Component of Red Wine, Elicits Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and Potassium Channels2007

    • Author(s)
      Nagaoka T, Hein T, Yoshida A, Kuo L
    • Journal Title

      Invest Ophthalmol Vis Sci 2007 48(9)

      Pages: 4232-4239

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prorenin levels in retinopathy of prematurity2007

    • Author(s)
      Yokota H, Nagaoka T, Mori F, Hikichi T, Hosokawa H, Tanaka H, Ishida Y, Suzuki F, Yoshida A
    • Journal Title

      Am J Ophthalmol 143(3)

      Pages: 531-3

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Simvastatin Elicits Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and Mevalonate-Rho Kinase Pathway2007

    • Author(s)
      Nagaoka T, Hein T, Yoshida A, Kuo L
    • Journal Title

      Invest Ophthalmol Vis Sci 48(5)

      Pages: 825-832

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retinal circulatory changes associated with interferon-induced retinopathy in patients with hepatitis C2007

    • Author(s)
      Nagaoka T, Sato E, Takahashi A, Yokohama S, Yoshida A
    • Journal Title

      Invest Ophthalmol Vis Sci 48(1)

      Pages: 368-375

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Retinal circulatory changes and interferon therapy in patients with hepatitis C : role of retinal circulation in interferon-induced retinopathy.2007

    • Author(s)
      Nagaoka T, Sato E, Takahashi A, Yokohama S, Yoshida A.
    • Journal Title

      Investigative Ophthalmollogy & Visual Science 48

      Pages: 368-375

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simvastatin elicits dilation of isolated porcine retinal arterioles : role of nitric oxide and mevalonate-rho kinase pathway2007

    • Author(s)
      Nagaoka T, Hein T, Yoshida A, Kuo L
    • Journal Title

      Investigative Ophthalmollogy & Visual Science 48

      Pages: 825-832

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prorenin levels in retinopathy of prematurity.2007

    • Author(s)
      Yokota H, Nagaoka T, Mori F,, et al
    • Journal Title

      American Journal of Ophthalmology 143

      Pages: 531-533

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resveratrol, a constituent of red wine, elicits dilation of isolated porcine retinal arterioles : role of nitric oxide and potassium channels.2007

    • Author(s)
      Nagaoka T, Hein T, Yoshida A, Kuo L
    • Journal Title

      Investigative Ophthalmollogy & Visual Science 48

      Pages: 4232-4239

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional and Molecular Characterization of the Endothelin System in Retinal Arterioles

    • Author(s)
      Hein TW, Ren Y, Yuan Z, Xu W, Somvanshi S, Nagaoka T, Yoshida A, Kuo L
    • Journal Title

      Invest Ophthalmol Vis Sci (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Macular Microcirculation and Macular Oedema in Branch Retinal Vein Occlusion

    • Author(s)
      Noma H, Funatsu H, Sakata K, Harino S, Nagaoka T, Mimura T, Sone T, Hori S.
    • Journal Title

      Br J Ophthalmol (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Systemic Administration of Valsaltan, an Angiotensin II Type 1 Receptor Blocker, on Retinal Circulation in healthy humans

    • Author(s)
      Nagaoka T, Takahashi A, Sato E, Yokota A, Izumi N, Takahashi A, Yoshida A
    • Journal Title

      Eye (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Presentation] Change in Retinal Blood Flow Associated With Duration of Type 2 Diabetes Mellitus2008

    • Author(s)
      Nagaoka T
    • Organizer
      ARVO meeting
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2008-05-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of Panretinal Photocoagulation on Pulsatile Ocular Blood Flow in Patients With Proliferative Diabetic Retinopathy Invest Ophthalmol Vis Sci 2008; E-Abstract 27402008

    • Author(s)
      A. Takahashi, T. Nagaoka, E. Sato, A. Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] 1.Reduced Compliance of the Retinal Arteriolar Circulation With Increased Serum Prorenin in Patients With Type 2 Diabetes Invest Ophthalmol Vis Sci 2008; E-Abstract 27412008

    • Author(s)
      H. Yokota, T. Nagaoka, A. Takahashi1, E. Sato, A. Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] Change in Retinal Blood Flow Associated With Duration of Type 2 Diabetes Mellitus Invest Ophthalmol Vis Sci 2008; E-Abstract 35092008

    • Author(s)
      T. Nagaoka, A. Takahashi, H. Yokota, E. Sato, K. Sogawa, A. Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] Acute Hyperglycemia Induces the Endothelial Dysfunction of Retinal Arteries Invest Ophthalmol Vis Sci 2008; E-Abstract 53642008

    • Author(s)
      K. Sogawa, T. Nagaoka, E. Sato, A. Takahashi, N. Izumi, A. Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] C-reactive Protein Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Isolated Porcine Retinal Arterioles.2007

    • Author(s)
      Nagaoka T
    • Organizer
      ARVO meeting
    • Place of Presentation
      Fort Lauderdale, FL, USA
    • Year and Date
      2007-04-24
    • Related Report
      2007 Annual Research Report
  • [Presentation] Role of Nitric Oxide in Regulation of Retinal Blood Flow in Response to Hyperoxia in Cats Invest Ophthalmol Vis Sci 2007; E-Abstract 8712007

    • Author(s)
      N. Izumi, T. Nagaoka, E. Sato, K. Sogawa, H. Kagokawa, A. Takahashi, A. Kawahara, A. Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] Relation Between Serum Levels of Prorenin and Retinal Circulation in Patients With Type 2 Diabetes Mellitus Without Retinopathy Invest Ophthalmol Vis Sci 2007; E-Abstract 37652007

    • Author(s)
      H.Yokota, T.Nagaoka, A.Takahashi, E.Sato, A.Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of Topical Tafluprost on Retinal and Ocular Nerve Head Circulation in Normal Human Eyes. Invest Ophthalmol Vis Sci 2007; E-Abstract 22802007

    • Author(s)
      A.Takahashi, E.Sato, T.Nagaoka, A.Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] C-reactive Protein Inhibits Endothelium-Dependent Nitric Oxide-Mediated Dilation of Isolated Porcine Retinal Arterioles. Invest Ophthalmol Vis Sci 2007; E-Abstract 22712007

    • Author(s)
      T.Nagaoka1,2, L.Kuo1, A.Yoshida2, T.W. Hein1
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] Retinal Hemodynamics in Patients With Normal Tension Glaucoma Invest Ophthalmol Vis Sci 2007; E-Abstract 43962007

    • Author(s)
      E.Sato, A.Takahashi, M.Kawai, T.Nagaoka, A.Yoshida
    • Organizer
      Annual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Presentation] Role of VEGFR2 in the Dilation of Retinal Arterioles to Increased Lumenal Flow. Invest Ophthalmol Vis Sci 2007; E-Abstract 60412007

    • Author(s)
      R.H. Rosa, Jr., T.W. Hein, T.Nagaoka, W.Xu, Z.Yuan, L.Kuo
    • Organizer
      nnual meeting of the association of research in vision and Ophthalmology
    • Place of Presentation
      米国、フロリダ
    • Related Report
      2008 Final Research Report
  • [Book] 眼科臨床に必要な解剖生理, VI. 網膜・脈絡膜 4.網膜の血流. 眼科プラクティス62007

    • Author(s)
      長岡泰司
    • Publisher
      文光堂
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.asahikawamed.ac.jp/dept/mc/ophtha/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/ophtha/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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