Regulation of bone remodeling
| Project/Area Number |
19689036
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAKASHIMA Tomoki Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (00346959)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2007: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Keywords | 口腔生化学 / 骨代謝学 / 骨リモデリング / 破骨細胞 / 骨細胞 / トランスクリプトーム / 骨芽細胞 / コンデッショナル遺伝子改変マウス |
|---|
| Research Abstract |
Bone remodeling optimizes bone strength and mineral metabolism. Control of bone remodeling requires a tightly orchestrated interplay among osteoblasts (bone forming cells), osteoclasts (bone resorbing cells) in bone surface and osteocytes, which embedded into bone. To identify the regulation factor of bone remodeling, we performed a genome-wide screening of these bone cells and in vivo analysis of gene targeting mice.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers : The significance of IL-6 synthesized by stromal cells in response to cancer cells2010
Author(s)
Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Nguyen ST, Omura K, Miki Y, Akashi T, Ogata E, Yamaguchi A
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Journal Title
Am J Pathol 176
Pages: 968-980
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Peer Reviewed
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[Journal Article] Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.2007
Author(s)
Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kroemer G, Kahn CR, Rustin P, Burcelin R, Penninger JM
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Peer Reviewed
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[Presentation] RANKLの役割2007
Author(s)
中島友紀
Organizer
第25回内分泌・代謝学サマーセミナー
Place of Presentation
兵庫(招待講演)
Year and Date
2007-07-17
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