| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2009: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2008: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2007: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
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| Research Abstract |
Most of bones were formed through unique ossification pathway called endochondral ossification. It is well known that transcriptional factor Sox9 is essential for chondrocyte differentiation. To understand the molecular basis for chondrogenesis, we established screening system which can allow us to identify transcriptional co-factor for Sox9. We have identified p54^<nrb> and Dmrt5 as a novel transcriptional partner for Sox9. Further studies revealed that p54^<nrb> modulate mRNA splicing of Sox9 target genes. Moreover, we found that Dmrt5 is involeved in Sox9 dependent sex differentiation as well as chondrocyte differentiation. Our findings indicate that the screening system is valid and the newly identified Sox9 transcriptional cofactor is important for chondrocyte differentiation.
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