Regulation of temporal and area specific expression of netrin-1 in the developing dorsal spinal cord

• Project/Area Number: 19700297
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Kumamoto University
• Principal Investigator: WATANABE Keisuke Kumamoto University, 大学院・生命科学研究部, 助教 (20446264)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥540,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: netrin-1 / 軸索誘導 / 発現調節 / 脊髄 / DRG / netrin1 / netrin 1

Research Abstract

We revealed that guidance molecule netrin-1 attracts ventral-ward migration of dorsal interneurons in the developing spinal cord. Furthermore, Gsg1, which is known to regulate neuroblast migration in C. elegans, is required for proper radial migration and dendrite formation of glutamatergic neurons during development of the cerebral cortex.

Research Products

• [Journal Article] Netrin 1 provides a chemoattractive cue for the ventral migration of GnRH neurons in the chick forebrain. (2010)
  • Author(s): Murakami S, Ohki-Hamazaki H, Watanabe K, Ikenaka K, Ono K
  • Journal Title: J. Comp. Neurol. 518 Pages: 2019-2034
  • Peer Reviewed
• [Journal Article] The ratio of DCC to UNC5A netrin-1 receptors on the growth cone regulates mossy fibre directionality. (2010)
  • Author(s): Muramatsu E, Nakahara S, Ichikawa J, Watanabe K, Matsuki N, Koyama R
  • Journal Title: Brain 133 Pages: 60-75
  • Peer Reviewed
• [Journal Article] Netrin 1 provides a chemottractive cue for the ventral migration of GnRH neurons in the chick forbrain (2010)
  • Author(s): Murakami, et al.
  • Journal Title: J.Comp.Neurol. (印刷中)
  • Peer Reviewed
• [Journal Article] The ratio of DCC to UNC5A netrin-1 receptors on the growth cone regulates mossy fibre directionality. (2010)
  • Author(s): Muramatsu, et al.
  • Journal Title: Brain 133 Pages: 60-75
  • Peer Reviewed
• [Journal Article] Netrin1 signaling and dorsal spinal cord formation. (2009)
  • Author(s): Ono K, Watanabe K
  • Journal Title: J. Kyoto Pref. Univ. Med. 118 Pages: 77-85
  • NAID: 110007007238
• [Journal Article] Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice. (2009)
  • Author(s): Tanahira C, Higo S, Watanabe K, Tomioka R, Ebihara S, Kaneko T, Tamamaki N
  • Journal Title: Neurosci. Res 63 Pages: 213-223
  • Peer Reviewed
• [Journal Article] Netrin1 signaling and dorsal spinal cord formation. (in Japanese) (2009)
  • Author(s): Ono, Watanabe
  • Journal Title: Kyoto Pref.Univ.Med. 118 Pages: 77-85
• [Journal Article] Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice (2009)
  • Author(s): Tanahira C., et.al.
  • Journal Title: Neuroscience Research 63 Pages: 213-223
  • Peer Reviewed
• [Journal Article] Netrin-1 Acts as a Repulsive Guidance Cue for Sensory Axonal Projections toward the Spinal Cord. (2008)
  • Author(s): Masuda T, * Watanabe K, * Sakuma C, * Ikenaka K, Ono K, Yaginuma H
  • Journal Title: J. Neurosci. 28 Pages: 10380-10385
  • Peer Reviewed
• [Journal Article] Regional- and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium. (2008)
  • Author(s): Ono K, Takebayashi H, Ikeda K, Furusho M, Nishizawa T, Watanabe K, Ikenaka K
  • Journal Title: Dev. Biol 320 Pages: 456-468
  • Peer Reviewed
• [Journal Article] Netrin-1 acts as a repulsive guidance cue for sensory axonal projections toward the spinal cord (2008)
  • Author(s): Masuda T., et.al.
  • Journal Title: The Journal of Neuroscience 28 Pages: 10380-10385
  • Peer Reviewed
• [Journal Article] Regional-and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium (2008)
  • Author(s): Ono K., et.al.
  • Journal Title: Developmental Biology 320 Pages: 456-468
  • Peer Reviewed
• [Presentation] Novel membrane protein Gsg1 is essential for neuronal migration and dendrite formation of cortical pyramidal neurons (2010)
  • Author(s): 渡辺啓介
  • Organizer: 第4回神経発生討論会
  • Place of Presentation: 自然科学研究機構、愛知
• [Presentation] Novel membrane protein Gsg1 is essential for neuronal migration and dendrite formation of cortical pyramidal neurons (2010)
  • Author(s): 渡辺啓介, 他
  • Organizer: 第4回神経発生討論会
  • Place of Presentation: (愛知県岡崎市)岡崎コンフアレンスセンター
• [Presentation] Identification of genes specific to glutamatergic-neuron precursors in the developing mouse neocortex (2009)
  • Author(s): 渡辺啓介
  • Organizer: COEサマーリトリートセミナー
  • Place of Presentation: ホテルグリーンピア南阿蘇、熊本
• [Presentation] Identification of genes specific to glutamatergic-neuron precursors in the developing mouse neocortex (2009)
  • Author(s): 渡辺啓介
  • Organizer: 第32回神経科学大会
  • Place of Presentation: 名古屋国際会議場、愛知
• [Presentation] Identification of glutamatergic neuronal lineage-specific genes in the developing mouse neocortex (2009)
  • Author(s): 渡辺啓介, 他
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: (愛知県名古屋市)名古屋国際会議場
• [Presentation] タイムラプスビデオ撮影によるIntermediate GABAergic neuron progenitorsの分裂像の観察 (2008)
  • Author(s): 渡辺啓介, 他
  • Organizer: 第31回神経科学大会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] Videomicroscopic observation of the proliferating intermediate GABAergic neuron progenitors in vitro (2008)
  • Author(s): 渡辺啓介
  • Organizer: 第31回神経科学大会
  • Place of Presentation: 東京国際フォーラム、東京