A study for axon regeneration in the damaged CNS -clarification of inhibitory mechanisms of chondroitin sulfate proteoglycan

Research Project

Project/Area Number	19700301
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Neuroscience in general
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	KUBOYAMA Tomoharu The Institute of Physical and Chemical Research, 神経成長機構研究チーム, 研究員 (10415151)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,800,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥600,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2007: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywords	コンドロイチン硫酸プロテオグリカン / プロテインキナーゼA / 細胞接着斑 / パキシリン / 軸索再生 / dystrophic endball / paxillin / Lpaxillin
Research Abstract	I attempt to molecularly clarify why axons cannot regenerate in the damaged spinal cord where a gradient of chondroitin sulfate proteoglycan (CSPG) is formed. I used a culture system that reproduced axon endings failing to migrate forward on the inhibitory CSPG gradient. In this study, I conclude that regulation of cell-matrix adhesion formation plays a critical role in axon regeneration across the inhibitory CSPG gradient.

Report

(4 results)