Guidance mechanism of main and accessory olfactory bulb axons

• Project/Area Number: 19700325
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Institute of Genetics
• Principal Investigator: KAWASAKI Takahiko National Institute of Genetics, 総合遺伝研究系, 助教 (00322751)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,630,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
• Keywords: 神経回路網 / 神経発生 / 軸索ガイダンス / 嗅覚 / 嗅球

Research Abstract

本研究では主嗅球と副嗅球という嗅球の違いに注目しながら、嗅球から終脳中枢への軸索投射が胚発生期にどのように制御されているのかを明らかにしようと解析を進めた。in vitroやin vivoの解析によって、主嗅球の軸索投射は主にSlit/Roboシグナリングが制御し、副嗅球の軸索投射は主にNrp2を介したSerna3/Nrp/Plnシグナリングが制御していることを明らかにした。

Research Products

• [Journal Article] Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface (2008)
  • Author(s): Keisuke Ito, Takahiko Kawasaki, Seiji Takashima, Ikuo Matsuda, Atsu Aiba, and Tatsumi Hirata
  • Journal Title: J. Neurosci. vol.28 Pages: 4414-4422
  • Peer Reviewed
• [Journal Article] Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface (2008)
  • Author(s): K. Ito, et.al.
  • Journal Title: Journal of Neuroscience 28 Pages: 4414-4422
  • Peer Reviewed
• [Journal Article] Semaphorin 3F confines ventral tangential migration of lateral olfactory tract neurons onto the telencephalon surface (2008)
  • Author(s): K. Ito, et. al.
  • Journal Title: Journal of Neuroscience 28 Pages: 4414-4422
  • Peer Reviewed
• [Journal Article] Robo1 and Robo2 control the development of the lateral olfactory tract (2007)
  • Author(s): Coralie Fouquet, Thomas Di Meglio, LeMa, Takahiko Kawasaki, Hua Long, Tatsumi Hirata, Marc Tessier-Lavigne, Alain Che'dotal, and Kim T. Nguyen-Ba-Charvet
  • Journal Title: J. Neurosci. vol.27 Pages: 3037-3045
  • Peer Reviewed
• [Journal Article] Robo1 and Robo2 control the development of the lateral olfactory tract (2007)
  • Author(s): C. Fouquet, et. al.
  • Journal Title: Journal of Neuroscience 27 Pages: 3037-3045
  • Peer Reviewed
• [Presentation] Novel function of Nrp2 as an inhibitor of Sema3A signaling in the projection of olfactory bulb axons (2009)
  • Author(s): Takahiko Kawasaki and Tatsumi Hirata
  • Organizer: The 32st Annual meeting of the Japan neuroscience society
  • Place of Presentation: 新潟
• [Presentation] 嗅球神経回路形成におけるセマフォリンシグナルの役割 (2008)
  • Author(s): 川崎能彦
  • Organizer: 日本神経科学学会
  • Place of Presentation: 東京
  • Year and Date: 2008-07-09
• [Presentation] セマフォリンシグナルによる嗅覚2次神経回路の形成機構 (2008)
  • Author(s): 川崎能彦
  • Organizer: 日本発生生物学会
  • Place of Presentation: 徳島
  • Year and Date: 2008-05-28
• [Presentation] The role of semaphorin signaling in the olfactory bulb projections (2008)
  • Author(s): Takahiko Kawasaki and Tatsumi Hirata
  • Organizer: The 31st Annual meeting of the Japan neuroscience society
  • Place of Presentation: 東京
• [Presentation] The role of semaphorin signaling in the projections of olfactory bulb axons (2008)
  • Author(s): Takahiko Kawasaki and Tatsumi Hirata
  • Organizer: 41st Annual meeting for the Japanese society of developmental biology
  • Place of Presentation: 徳島
• [Presentation] 主嗅球と副嗅球の軸索ガイダンス機構 (2007)
  • Author(s): 川崎能彦
  • Organizer: 日本発生生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-28
• [Presentation] Guidance of main and accessory olfactory bulb axons (2007)
  • Author(s): Takahiko Kawasaki and Tatsumi Hirata
  • Organizer: 40st Annual meeting for the Japanese society of developmental biology
  • Place of Presentation: 福岡