Mechanisms of the extrapyramidal symptoms caused by methylmercury chloride

Research Project

Project/Area Number	19700334
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Nerve anatomy/Neuropathology
Research Institution	National Institute for Minamata Disease
Principal Investigator	MARUMOTO Masumi 国立水俣病総合研究センター, 基礎研究部, 主任研究員 (00335506)
Project Period (FY)	2007 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥6,373,279 (Direct Cost: ¥5,110,215、Indirect Cost: ¥1,263,064) Fiscal Year 2011: ¥1,183,279 (Direct Cost: ¥910,215、Indirect Cost: ¥273,064) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Keywords	メチル水銀 / 水俣病 / マウス / 線条体 / 小型神経細胞 / 錐体外路 / 無機水銀 / 局在 / 神経細胞 / ミクログリア / アストログリア / 可視化 / 自発運動量 / 錐体外路障害
Research Abstract	The patients who had severe symptom of Minamata disease and, in the case that an extrapyramidal sign was observed clinically, showed pathological changes in the extrapyramidal tract nuclei. In addition, pathological changes were observed in the extrapyramidal tract nuclei in the case that whole brain was damaged severely. The methylmercury treated mice displayed locomotor hyperactivity. Histopathological examination showed significant decrease in the number of neurons with proliferation of astroglias in the bilateral caudate putamen in the methylmercury treated mice.