The role of BDNF/trkB signaling in the transition to postherpetic neuralgia

• Project/Area Number: 19700337
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: University of Toyama
• Principal Investigator: TAKASAKI Ichiro University of Toyama, 生命科学先端研究センター, 助教 (00397176)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,520,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 帯状疱疹痛 / 帯状疱疹後神経痛 / 神経栄養因子

Research Abstract

帯状疱疹から帯状疱疹後神経痛への発症機序は明らかでない。本研究は脳由来神経栄養因子(BDNF)とその受容体trkBに注目し、帯状疱疹後神経痛への移行における脊髄BDNF/trkBシグナリングの役割について解析した。帯状疱疹痛マウスの脊髄においてBDNF産生量が増加し、抗体等でBDNFのはたらきをブロックすると、帯状疱疹痛を抑制し、帯状疱疹後神経痛への移行も抑制された。本研究の成果により、帯状疱疹後神経痛への移行におけるBDNF/trkB受容体の関与が明らかとなった。

Research Products

• [Journal Article] Extracellular Adenosine 5'-Triphosphate Elicits the Expression of Brain- Derived Neurotrophic Factor Exon IV mRNA in Rat Astrocytes (2008)
  • Author(s): Takasaki I, Takarada S, Tatsumi S, Azegami A, Yasuda M, Fukuchi M, Tabuchi A, Kondo T, Tabuchi Y, and Tsuda M
  • Journal Title: GLIA 56 Pages: 1369-1379
  • Peer Reviewed
• [Journal Article] Morphine inhibits herpetic allodynia through mu-opioid receptors in Abeta-fiber neurons (2008)
  • Author(s): Sasaki A, Nakashima Y, Takasaki I, Andoh T, Shiraki K, Kuraishi Y
  • Journal Title: Neuroreport 19 Pages: 975-979
  • Peer Reviewed
• [Journal Article] Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice (2008)
  • Author(s): Sasaki A, Takasaki I, Andoh T, Shiraki K, Takeshima H, Takahata H, and Kuraishi Y
  • Journal Title: Neuroreport 19 Pages: 83-86
  • Peer Reviewed
• [Journal Article] Extracellular Adenosine 5-Triphosphate Elicits the Expression of Brain-Derived Neurotrophic Factor Exon IV mRNA in Rat Astrocytes (2008)
  • Author(s): Takasaki, et.al.
  • Journal Title: GLIA 56 Pages: 1369-1379
  • Peer Reviewed
• [Journal Article] Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice (2008)
  • Author(s): Sasaki, et.al.
  • Journal Title: NeuroReport 19 Pages: 83-86
  • Peer Reviewed
• [Journal Article] Morphine inhibits herpetic allodynia through mu-opioid receptors in Abe to-fiber neurons (2008)
  • Author(s): Sasaki, et.al.
  • Journal Title: NeuroReport 19 Pages: 975-979
  • Peer Reviewed
• [Journal Article] Different roles of nitric oxide synthase -1 and -2 between herpetic and postherpetic allodynia in mice (2007)
  • Author(s): Sasaki A, Mabuchi T, Serizawa K, Takasaki I, Andoh T, Shiraki K, Ito S, and Kuraishi Y
  • Journal Title: Neuroscience 150 Pages: 459-66
  • Peer Reviewed
• [Journal Article] Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice (2007)
  • Author(s): Sasaki A, Nakashima Y, Takasaki I, Andoh T, Shiraki K and Kuraishi Y
  • Journal Title: J. Pharmacol. Sci 104 Pages: 218-224
  • NAID: 10024314645
  • Peer Reviewed
• [Journal Article] Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-12 (2007)
  • Author(s): Takasaki I, Takarada S, Fukuchi M, Yasuda M, Tsuda M and Tabuchi Y
  • Journal Title: J. Cell. Biochem 102 Pages: 1472-1485
  • Peer Reviewed
• [Journal Article] Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-12. (2007)
  • Author(s): Takasaki, et. al.
  • Journal Title: J Cell. Biochem. 102 Pages: 1472-1485
  • Peer Reviewed
• [Journal Article] Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice. (2007)
  • Author(s): Sasaki, et. al.
  • Journal Title: J. Pharmacol. Sci. 104 Pages: 218-224
  • Peer Reviewed
• [Journal Article] Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice. (2007)
  • Author(s): Sasaki, et. al.
  • Journal Title: Neuroscience 150 Pages: 459-466
  • Peer Reviewed
• [Presentation] Extracellular ATP elicits the expression of BDNF exon IV mRNA in rat astrocytes and astrocyte cell line RCG-12 (2008)
  • Author(s): Takasaki I, Takarada S, Tatsumi S, Azegami A, Yasuda M, Fukuchi M, Tabuchi A, Kondo T, Tabuchi Y, and Tsuda M
  • Organizer: The 38th Annual Meeting of the Society for Neuroscience (Neuroscience 2008)
  • Place of Presentation: Washington DC, USA
• [Presentation] アストロサイトにおけるATP誘導性BDNF遺伝子発現上昇メカニズムの解析 (2007)
  • Author(s): 立見沙織, 高崎一朗, 宝田聡子, 田渕圭章, 津田正明
  • Organizer: 日本薬学会北陸支部第117回例会
  • Place of Presentation: 金沢
  • Year and Date: 2007-11-11
• [Presentation] 帯状疱疹痛と帯状疱疹後神経痛のモデルマウス (2007)
  • Author(s): 高崎一朗, 佐々木淳, 安東嗣修, 白木公康, 倉石泰
  • Organizer: 北陸実験動物研究会
  • Place of Presentation: 富山
  • Year and Date: 2007-09-15
• [Presentation] 網羅的遺伝子発現解析に基づいた帯状疱疹痛発症機序の解明 (2007)
  • Author(s): 高崎一朗, 倉石泰
  • Organizer: 第24回麻酔メカニズム研究会
  • Place of Presentation: 大阪
  • Year and Date: 2007-07-21
• [Presentation] 帯状疱疹痛モデルマウスの疼痛発症における脊髄galectin-3の関与 (2007)
  • Author(s): 高崎一朗, 小松史明, 谷口佳奈, 佐々木淳, 安東 嗣修, 加藤一郎, 平賀紘一, 白木公康, 倉石泰
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山