Modulatory effects of oligodendrocytes on axonal conduction of action potentials

• Project/Area Number: 19700356
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Yamagata University
• Principal Investigator: YAMAZAKI Yoshihiko Yamagata University, 医学部, 准教授 (10361247)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 海馬 / 白板 / オリゴデンドロサイト / 活動電位 / グルタミン酸受容体 / 伝導速度 / 髄鞘 / ラット

Research Abstract

Oligodendrocytes in the alveus of hippocampus were found to respond to exogenously applied glutamate receptors with depolarization. Electrical stimulation evoked inward currents through various routes involving glutamate receptors and inward rectifier potassium channels. Direct depolarization of oligodendrocytes shortened the latencies of action potentials, indicating that oligodendrocytes increase the conduction velocity of action potentials by another mechanism in addition to saltatory conduction and play active roles in information processing in the brain.

Research Products

• [Journal Article] Nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via Ca^<2+> entry through non-α7 nicotinic acetylcholine receptors (2010)
  • Author(s): Jia, Yamazaki, et al.
  • Journal Title: European Journal of Neuroscience 31 Pages: 463-476
  • Peer Reviewed
• [Journal Article] Oligodendrocytes: Facilitating axonal conduction by more than myelination. (2009)
  • Author(s): Yamazaki Y, Hozumi Y, Kaneko K, Fujii S, Goto K, Kato H.
  • Peer Reviewed
• [Journal Article] α2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits. (2009)
  • Author(s): Jia Y, Yamazaki Y, Nakauchi S, Sumikawa K.
  • Journal Title: Eur J Neurosci 29 Pages: 1588-1603
  • Peer Reviewed
• [Journal Article] Oligodendrocytes : Faciitating axonal conduction by more than Myelination (2009)
  • Author(s): Yamazaki, et al.
  • Journal Title: The Neuroscientist DOI:10.1177/1073858409334425
  • Peer Reviewed
• [Journal Article] α2 nicotine receptors function as a molecular switch to continuously excite a subset of interneurons in rat hippocampal circuits (2009)
  • Author(s): Jia, Yamazaki, et al.
  • Journal Title: European Journal of Neuroscience 29 Pages: 1588-1603
  • Peer Reviewed
• [Journal Article] Modulatory effects of oligodendrocytes on the conduction velocity of action potentials along axons in the alveus of the rat hippocampal CA1 region. (2008)
  • Author(s): Yamazaki Y, Hozumi Y, Kaneko K, Sugihara T, Fujii S, Goto K, Kato H.
  • Journal Title: Neuron Glia Biology 3 Pages: 325-334
  • Peer Reviewed
• [Journal Article] Modulatory effects of oligodendrocytes on the conduction velocity of action potentials along axons in the alveus of the rat hippocampal CA1 region (2008)
  • Author(s): Yamazaki, et.al.
  • Journal Title: Neuron Glia Biology 3 Pages: 325-334
  • Peer Reviewed
• [Journal Article] Acute and chronic ethanol exposure differentially affect induction of hippocampal LTP (2008)
  • Author(s): Fujii, et.al.
  • Journal Title: Brain Research 1211 Pages: 13-21
  • Peer Reviewed
• [Journal Article] 介在ニューロン付随性グリア細胞による神経活動の修飾 (2007)
  • Author(s): 山崎良彦, 加藤宏司
  • Journal Title: Brain and Nerve 59 Pages: 689-695
• [Journal Article] Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance (2007)
  • Author(s): Tanaka KF, Takebayashi H, Yamazaki Y, Kato H, Ono K, Iwasato T, Itohara S, Ikenaka K.
  • Journal Title: Glia 55 Pages: 617-631
  • Peer Reviewed
• [Journal Article] Chronic nicotine exposure affects the normal operation of hippocampal circuits (2007)
  • Author(s): Nakauchi, et. al.
  • Journal Title: Neuroreport 18 Pages: 87-91
  • Peer Reviewed
• [Presentation] アストロサイト機能不全マウスにおけるグルタミン酸取り込み機能の変化 (2009)
  • Author(s): 山崎良彦
  • Organizer: 第42回東北生理談話会
  • Place of Presentation: 盛岡
  • Year and Date: 2009-10-17
• [Presentation] Modulation of the axonal conduction by oligodendrocytes in the alveus of the rat hippocampus. Myelin Development, Function and Related Diseases. (2009)
  • Author(s): Yamazaki Y.
  • Organizer: The 9th Biennial Satellite Meeting of the ISN on Myelin Biology
  • Place of Presentation: Gyeongju, S. Korea.
  • Year and Date: 2009-08-31
• [Presentation] Modulation of the axonal conduction by oligodendrocytes in the alveus of the rat hippocampus (2009)
  • Author(s): 山崎良彦
  • Organizer: The 9th Biennial Satellite Meeting of the ISN on Myelin Biology
  • Place of Presentation: Gyeongju, S.Korea
  • Year and Date: 2009-08-21
• [Presentation] 海馬白板のオリゴデンドロサイトの同定および活動電位の軸索伝導に対する修飾効果 (2009)
  • Author(s): 山崎良彦
  • Organizer: 平成21年度生理学研究所研究会神経科学の新しい解析法とその応用.
  • Place of Presentation: 岡崎
  • Year and Date: 2009-07-18
• [Presentation] 海馬白板のオリゴデンドロサイトの同定および活動電位の軸索伝導に対する修飾効果 (2009)
  • Author(s): 山崎良彦
  • Organizer: 平成21年度 生理学研究所研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2009-07-18
• [Presentation] Modulation of neuronal activities by interactions between neurons and glial cells. (2009)
  • Author(s): Yamazaki Y.
  • Organizer: Hirosaki International Forum of Medical Science.
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] Modulation of neuronal activities by interactions between neurons and glial cells (2009)
  • Author(s): Yamazaki, et.al.
  • Organizer: The 11th Meeting of the Hirosaki International Forum of Medical Science
  • Place of Presentation: Hirosaki
  • Year and Date: 2009-03-27
• [Presentation] 介在ニューロン付随性オリゴデンドロサイトの形態と機能 (2008)
  • Author(s): 山崎良彦
  • Organizer: 第41回東北生理談話会.
  • Place of Presentation: 弘前
  • Year and Date: 2008-10-18
• [Presentation] 介在ニューロン付随性オリゴデンドロサイトの形態と機能 (2008)
  • Author(s): 山崎良彦
  • Organizer: 第41回東北生理談話会
  • Place of Presentation: 弘前
  • Year and Date: 2008-10-18
• [Presentation] Properties of oligodendrocytes and its modulatory effects on conduction of action potentials in alveus of rat hippocampus. (2008)
  • Author(s): Yamazaki Y.
  • Organizer: US-Japan joint meeting for Glial Research
  • Place of Presentation: Philadelphia. USA.
• [Presentation] Oligodendrocytes modulate conduction of action potentials in alveus of rat hippocampus (2007)
  • Author(s): Yamazaki Y.
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2007-11-04
• [Presentation] Oligodendrocytes modulate conduction of action potentials in alveus of rat hippocampus (2007)
  • Author(s): Yamazaki, et. al.
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego
  • Year and Date: 2007-11-04
• [Presentation] 海馬白板のオリゴデンドロサイトによる活動電位の伝導に対する修飾効果 (2007)
  • Author(s): 山崎良彦
  • Organizer: 第40回東北生理談話会
  • Place of Presentation: 仙台
  • Year and Date: 2007-10-20
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/PhysiologyII/Physiol2-J.html
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/PhysiologyII/Physiol2-J.html