Interacion between proteinase-activated receptors and TRP channels in regulating nociceptive transmission in the rat spinal dorsal horn

• Project/Area Number: 19700358
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Saga University
• Principal Investigator: FUJITA Tsugumi Saga University, 医学部, 助教 (70336139)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,180,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: PAR / TRPV1 / ホールセル・パッチクランプ / EPSC / ラット / 膠様質 / 痛覚情報伝達 / トロンビン / TRP

Research Abstract

ラット脊髄膠様質ニューロンにホールセル・パッチクランプ法を適用し、痛覚情報伝達制御におけるプロテアーゼ受容体(PAR-1)の役割を調べた。外因性および内因性アゴニストで活性化されたPAR-1は、自発性のグルタミン酸放出を増加させたが、後根電気刺激による一次感覚神経終末からのグルタミン酸放出には影響しなかった。以上より、PAR-1活性化によるグルタミン酸放出増加はグルタミン酸作動性介在ニューロン末端から起こるものであり、TRPV1チャネル活性化とは直接相互作用しないことが示唆された。

Research Products

• [Journal Article] TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase (2009)
  • Author(s): L. -H. Piao, T. Fujita, C. -Y. Jiang, T. Liu, H.-Y. Yue, T. Nakatsuka, E. Kumamoto
  • Journal Title: Biochemical and Biophysical Research Communications 39(4) Pages: 980-984
  • Peer Reviewed
• [Journal Article] TRPA1 activation by lidocaine in nerve terminals results in glutamate release increase (2009)
  • Author(s): Lian-Hua Piao
  • Journal Title: Biochemical and Biophysical Research Communications 379 Pages: 980-984
  • Peer Reviewed
• [Journal Article] Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures (2008)
  • Author(s): K. Mizuta, T. Fujita, T. Nakatsuka, E. Kumamoto
  • Journal Title: Life Sciences 83(5-6) Pages: 198-207
  • Peer Reviewed
• [Journal Article] Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord: a possible involvement of somatostatin (2008)
  • Author(s): T. Nakatsuka, T. Fujita, K. Inoue, E. Kumamoto
  • Journal Title: Journal of Physiology 586(10) Pages: 2511-2522
  • Peer Reviewed
• [Journal Article] Phospholipase A2 activation enhances inhibitory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): T. Liu, T. Fujita, T. Nakatsuka, E. Kumamoto
  • Journal Title: Journal of Neurophysiology 99(3) Pages: 1274-1284
  • Peer Reviewed
• [Journal Article] Effects of galanin on excitatory synaptic transmission in adult rat substantia gelatinosa neurons (2008)
  • Author(s): H. -Y. Yue, T. Fujita, T. Liu, L. -H. Piao, C. -Y. Jiang, K. Mizuta, D. Tomohiro, T. Nakatsuka, E. Kumamoto
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30(1) Pages: 32-41
  • NAID: 40016473967
  • Peer Reviewed
• [Journal Article] Excitation of spinal motoneurons by activation of ATP receptors (2008)
  • Author(s): T. Aoyama, T. Nakatsuka, S. Koga, T. Fujita, E. Kumamoto
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30(1) Pages: 25-31
  • Peer Reviewed
• [Journal Article] Inhibitory actions of opioids on compound action potentials in frog sciatic nerves (2008)
  • Author(s): K. Mizuta, T. Fujita, R. Katsuki, T. Kosugi, D. Tomohiro, T. Nakatsuka, E. Kumamoto
  • Journal Title: Pain Research 23(4) Pages: 185-194
  • NAID: 10024965117
  • Peer Reviewed
• [Journal Article] Activation of GIRK channels in substantia gelatinosa neurones of the adult rat spinal cord : a possible involvement of somatostatin (2008)
  • Author(s): Terumasa Nakatsuka
  • Journal Title: Journal of Physiology 586 Pages: 2511-2522
  • Peer Reviewed
• [Journal Article] Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures (2008)
  • Author(s): Kotaro Mizuta
  • Journal Title: Life Sciences 83 Pages: 198-207
  • Peer Reviewed
• [Journal Article] Inhibitory actions of opioids on compound action potentials in frog sciatic nerves (2008)
  • Author(s): Kotaro Mizuta
  • Journal Title: Pain Research 23 Pages: 185-194
  • Peer Reviewed
• [Journal Article] Excitation of spinal motoneurons by activation of ATP receptors (2008)
  • Author(s): Takahiro Aoyama
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 25-31
  • Peer Reviewed
• [Journal Article] Effects of galanin on excitatory synaptic transmission in adult rat substantia gelatinosa neurons (2008)
  • Author(s): Hai-Yuan Yue
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 30 Pages: 32-41
  • Peer Reviewed
• [Journal Article] Phospholipase A_2 activation enhances inhibitory synaptic transmission in ratsubstantia gelatinosa neurons. (2008)
  • Author(s): Tao Liu
  • Journal Title: Journal of Neurophysiology 99 Pages: 1274-1284
  • Peer Reviewed
• [Journal Article] Activation of TRPA1 channel facilitates excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): M. Kosugi, T. Nakatsuka, T. Fujita, Y. Kuroda, E. Kumamoto
  • Journal Title: The Journal of Neuroscience 27(16) Pages: 4443-4451
  • Peer Reviewed
• [Journal Article] The effect of TRPA1 activation on excitatory synaptic transmission in the spinal dorsal horn (2007)
  • Author(s): M. Kosugi, T. Nakatsuka, T. Fujita, T. Aoyama, E. Kumamoto
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 29(1) Pages: 15-20
  • NAID: 40016271743
  • Peer Reviewed
• [Journal Article] Proteinase-activated receptor-1 activation presynaptically enhances spontaneous excitatory synaptic transmission in adult rat substantia gelatinosa neurons (2007)
  • Author(s): T. Fujita, T. Liu, K. Mizuta, T. Nakatsuka, E. Kumamoto
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 29(1) Pages: 8-14
  • Peer Reviewed
• [Journal Article] Phospholipase A2 activation enhances inhibitory synaptic transmission in the rat substantia gelatinosa (2007)
  • Author(s): T. Liu, T. Fujita, T. Nakatsuka, E. Kumamoto
  • Journal Title: Pain Research 22(1) Pages: 11-18
  • NAID: 10018864269
  • Peer Reviewed
• [Journal Article] Proteinase-activated receptor-1 activation presynaptically enhances spontaneous excitatory synaptic transmission in adult rat substantia gelatinosa neurons. (2007)
  • Author(s): Tsugumi Fujita
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 8-14
  • Peer Reviewed
• [Journal Article] Activation of TRPA1 channel facilitates excitatory synaptic transmission insubstantia gelatinosa neurons of the adult rat spinal cord. (2007)
  • Author(s): Masafumi Kosugi
  • Journal Title: The Journal of Neuroscience 27 Pages: 4443-4451
  • Peer Reviewed
• [Journal Article] The effect of TRPA1 activation on excitatory synaptic transmission in the spinal dorsal horn. (2007)
  • Author(s): Masafumi Kosugi
  • Journal Title: The Journal of Functional Diagnosis of the Spinal Cord 29 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Phospholipase A_2 activation enhances inhibitory synaptic transmission in the rat substantia gelatinosa. (2007)
  • Author(s): Tao Liu
  • Journal Title: Pain Research 22 Pages: 11-18
  • Peer Reviewed
• [Journal Article] Proteinase-activated receptor-1 activation presynaptically enhances spontaneous glutamatergic excitatory transmission in adultrat substantia gelatinosa neurons
  • Author(s): T. Fujita, T. Liu, T. Nakatsuka, E. Kumamoto
  • Journal Title: Journal of Neurophysiology (in press)
  • Peer Reviewed
• [Presentation] パッチクランプ法を用いた脊髄電気刺激による鎮痛機構の解明 (2009)
  • Author(s): 中塚映政
  • Organizer: 第31回脊髄機能診断研究会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2009-02-07
• [Presentation] ラット脊髄後角におけるTRPチャネルのリドカインによる活性化 (2009)
  • Author(s): 朴蓮花
  • Organizer: 第31回脊髄機能診断研究会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2009-02-07
• [Presentation] パッチクランプ法を用いた脊髄電気刺激による鎮痛機構の解明 (2009)
  • Author(s): 中塚映政
  • Organizer: 平成20年度生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2009-01-22
• [Presentation] 成熟ラット脊髄膠様質におけるPAR-1活性化は興奮性シナプス伝達を促進する (2009)
  • Author(s): 藤田亜美
  • Organizer: 平成20年度生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2009-01-22
• [Presentation] ガラニンはラット脊髄膠様質における興奮性シナプス伝達を濃度に依存して二相性に制御する (2009)
  • Author(s): 熊本栄一
  • Organizer: 平成20年度生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2009-01-22
• [Presentation] ガラニンはラット脊髄膠様質における興奮性シナプス伝達を濃度に依存して二相性に制御する (2009)
  • Author(s): 熊本栄一
  • Organizer: 平成20年度生理学研究所研究会「筋・骨格系と内蔵の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2009-01-22
• [Presentation] 成熟ラット脊髄膠様質におけるPAR-1活性化は興奮性シナプス伝達を促進する (2009)
  • Author(s): 藤田亜美
  • Organizer: 平成20年度生理学研究所研究会「筋・骨格系と内蔵の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2009-01-22
• [Presentation] パッチクランプ法を用いた脊髄電気刺激による鎮痛機構の解明 (2009)
  • Author(s): 中塚映政
  • Organizer: 平成20年度生理学研究所研究会「筋・骨格系と内蔵の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2009-01-22
• [Presentation] Enhancement by resiniferatoxin of glutamatergic spontaneous excitatory synaptic transmission in rat spinal dorsal horn neurons (2008)
  • Author(s): C. -Y. Jiang
  • Organizer: 46th Annual Meeting of the Biophysical Society of Japan
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-12-04
• [Presentation] Enhancement by resiniferatoxin of glutamatergic spontaneous excitatory svnantic transmission in rat sninal dorsal horn neurons (2008)
  • Author(s): Chang-Yu Jiang
  • Organizer: 46th Annual Meeting of the Biophysical Society of Japan
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-12-04
• [Presentation] Relationship between inhibition by opioids of compound action potentials in frog sciatic nerves and their chemical structures (2008)
  • Author(s): Kotaro Mizuta
  • Organizer: 46th Annual Meeting of the Biophysical Society of Javan
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-12-04
• [Presentation] Cellular mechanism of spinal cord stimulation-evoked analgesia : a possible involvement of somatostatin (2008)
  • Author(s): T. Nakatsuka
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-19
• [Presentation] Cellular mechanisms for the phospholipase A2-mediated enhancement of inhibitory synaptic transmission in adult rat substantia gelatinosa neurons (2008)
  • Author(s): T. Liu
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-19
• [Presentation] Resiniferatoxin enhances excitatory synaptic transmission in adult rat spinal dorsal horn neurons (2008)
  • Author(s): C. -Y. Jiang
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-19
• [Presentation] Pre- and postsynaptic modulation by galanin of glutamatergic excitatory synaptic transmission in adult rat substantia gelatinosa neurons (2008)
  • Author(s): H. -Y. Yue
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-19
• [Presentation] L-Glutamate release from nerve terminals in the adult rat spinal dorsal horn is more effectively increased by PAR-1 than PAR-2 and PAR-4 agonists (2008)
  • Author(s): T. Fujita
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-19
• [Presentation] Cellular mechanisms for the phospholipase A_2-mediated enhancement of inhibitory synaptic transmission in adult rat substantia gelatinosa neurons (2008)
  • Author(s): Tao Liu
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-19
• [Presentation] Capsaicin and its analogs inhibit compound action potentials in frog sciatic nerves (2008)
  • Author(s): Daisuke Tomohiro
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-17
• [Presentation] Relationship of the chemical structures of opioids to their inhibitory actions on compound action potentials in frog sciatic nerves (2008)
  • Author(s): Kotaro Mizuta
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-17
• [Presentation] Inhibition by dexmedetomidine or compound action potentials in frog sciatic nerves without α_2 adrenoceptor activation (2008)
  • Author(s): Toshifumi Kosugi
  • Organizer: Society for Neuroscience 38th Annual Meeting
  • Place of Presentation: Washington, DC, USA
  • Year and Date: 2008-11-17
• [Presentation] Glutamatergic excitatory transmission in adult rat substantia gelatinosa neurons is enhanced more effectively by PAR-1 than PAR-2 and PAR-4 activating peptides (2008)
  • Author(s): T. Fujita
  • Organizer: 45th Japanese Peptide Symposium
  • Place of Presentation: 東京都江戸川区
  • Year and Date: 2008-10-30
• [Presentation] Action of galanin on synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord (2008)
  • Author(s): H. -Y. Yue
  • Organizer: 45th Japanese Peptide Symposium
  • Place of Presentation: 東京都江戸川区
  • Year and Date: 2008-10-29
• [Presentation] Facilitation by phospholipase A2 activation of inhibitory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): E. Kumamoto
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow, Scotland, UK
  • Year and Date: 2008-08-22
• [Presentation] Facilitation by phospholipase A_2 activation of inhibitory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): Eiichi Kumamoto
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow, Scotland, UK
  • Year and Date: 2008-08-22
• [Presentation] Presynaptic TRPA1-mediated facilitation of excitatory synaptic transmission in the spinal dorsal horn (2008)
  • Author(s): T. Nakatsuka
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow, Scotland, UK
  • Year and Date: 2008-08-21
• [Presentation] PAR-1 activating peptides and proteinases enhance the spontaneous release of L-glutamate from nerve terminals in adult rat spinal dorsal horn neurons (2008)
  • Author(s): T. Fujita
  • Organizer: 12th World Congress on Pain
  • Place of Presentation: Glasgow, Scotland, UK
  • Year and Date: 2008-08-21
• [Presentation] Cellular mechanism for spinal cord electrical stimulation-induced analgesia (2008)
  • Author(s): T. Nakatsuka
  • Organizer: The 30th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-20
• [Presentation] Mechanisms for inhibitory synaptic transmission enhancement by phospholipase A2 activation in the rat substantia gelatinosa (2008)
  • Author(s): T. Liu
  • Organizer: The 30th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-20
• [Presentation] Pre- and postsynaptic effect of galanin on excitatory synaptic transmission in rat spinal dorsal horn neurons (2008)
  • Author(s): H. -Y. Yue
  • Organizer: The 30th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-20
• [Presentation] Effect of dexmedetomidine on compound action potentials in frog sciatic nerves (2008)
  • Author(s): Toshifumi Kosugi
  • Organizer: The 30th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-20
• [Presentation] Mechanisms for inhibitory synaptic transmission enhancement by phosDholivase A_2 activation in the rat substantia gelatinosa (2008)
  • Author(s): Tao Liu
  • Organizer: The 30th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-20
• [Presentation] Galanin pre- and postsynaptically modulates excitatory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): H.-Y. Yue
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Effect of resiniferatoxin on excitatory synaptic transmission in adult rat substantia gelatinosa neurons (2008)
  • Author(s): C.-Y. Jiang
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Mechanisms for phospholipase A2-mediated enhancement of inhibitory transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): T. Liu
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Inhibition by tramadol of excitatory synaptic transmission in rat spinal dorsal horn neurons through μ-opioid receptor activation but not monoamine uptake inhibition (2008)
  • Author(s): L. -H. Piao
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] TRPA1 channel-mediated enhancement of excitatory synaptic transmission in the spinal dorsal horn (2008)
  • Author(s): T. Nakatsuka
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] L-Glutamate release from nerve terminals is enhanced by PAR-1 activation in the adult rat spinal dorsal horn (2008)
  • Author(s): T. Fujita
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Inhibitory actions of capsaicin and its analogs on compound action Potentials in frog sciatic nerves (2008)
  • Author(s): Daisuke Tomohiro
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Relationship between the chemical structures of opioids and their inhibitory actions on compound action potentials in frog sciatic nerves (2008)
  • Author(s): Kotaro Mizuta
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Dexmedetomidine inhibits compound action potentials in frog sciatic nerves without a2 adrenoceptor activation (2008)
  • Author(s): Toshifumi Kosugi
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Inhibition by tramadol of excitatory synaptic transmission in rat spinal dorsal horn neurons through u-opioid receptor activation but not monoamine uptake inhibition (2008)
  • Author(s): Lian-Hua Piao
  • Organizer: The 3rd Asian Pain Symposium
  • Place of Presentation: 福岡県福岡市
  • Year and Date: 2008-07-19
• [Presentation] Facilitation of excitatory synaptic transmission through activation of purinergic receptors in spinal motoneurons (2008)
  • Author(s): T. Aoyama
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-11
• [Presentation] Activation of GIRK channels in the spinal dorsal horn: a possible involvement of endogenous somatostatin (2008)
  • Author(s): T. Nakatsuka
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] Effects of galanin on excitatoryn synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): H.-Y. Yue
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] Lidocaine activates TRP channels in substantia gelatinosa neurons of the rat spinal cord (2008)
  • Author(s): L. -H. Piao,
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] Mechanisms for the enhancement of inhibitory transmission by phospholipase A2 activation in the spinal dorsal horn (2008)
  • Author(s): T. Liu
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] PAR-1 activating proteases as well as peptides presynaptically enhance excitatory transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): T. Fujita
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] Capsaicin and its analogs inhibit compound action potentials in trog sciatic nerves (2008)
  • Author(s): Daisuke Tomohiro
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] Dexmedetomidine inhibits compound action potentials in frog sciatic nerves (2008)
  • Author(s): Toshifumi Kosugi
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] Mechanisms for the enhancement of inhibitory transmission by phospholipase A, activation in the spinal dorsal horn (2008)
  • Author(s): Tao Liu
  • Organizer: The 31 st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] Effects of galanin on excitatory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): Hai-Yuan Yue
  • Organizer: The 31st Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-09
• [Presentation] The activation of GIRK channel by endogenously-released somatostatin in substantia gelatinosa neurons of the adult rat spinal cord (2008)
  • Author(s): T. Nakatsuka
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Galanin modulates excitatory synaptic transmission in rat substantia gelatinosa neurons (2008)
  • Author(s): H. -Y. Yue
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Melittin-induced enhancement of GABAergic but not glycinergic inhibitory transmission in rat spinal dorsal horn neurons is mediated by acetylcholine and norepinephrine (2008)
  • Author(s): T. Liu
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Tramadol inhibits glutamatergic excitatory synaptic transmission in rat spinal dorsal horn neurons by activating μ-opioid receptors without monoamine uptake inhibition (2008)
  • Author(s): L. -H. Piao
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Direct excitation of rat spinal motoneurons by activation of P2X and P2Y receptors (2008)
  • Author(s): T. Aoyama
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] PAR-1 activating peptides and proteinases enhance glutamatergic excitatory transmission in adult rat spinal dorsal horn neurons (2008)
  • Author(s): T. Fujita
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] PAR-1 activating peptides and proteinases enhance glutamatergic excitatory transmission in adult rat spinal dorsal horn neurons. (2008)
  • Author(s): Tsugumi Fujita
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Direct excitation of rat spinal motoneurons by activation of P2X and P2Y receptors. (2008)
  • Author(s): Takahiro Aoyama
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Melittin-induced enhancement of GABAergic but not glycinergic inhibitory transmission in rat spinal dorsal horn neurons is mediated by acetylcholine and norepinephrine. (2008)
  • Author(s): Tao Liu
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Galanin modulates excitatory synaptic transmission in rat substantia gelatinosa neurons. (2008)
  • Author(s): Hai-Yuan Yue
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] The activation of GIRK channel by endogenously-released somatostatin in substantia gelatinosa neurons of the adult rat spinal cord. (2008)
  • Author(s): Terumasa Nakatsuka
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-26
• [Presentation] Inhibition by capsaicin and its related substances of compound action potentials in frog sciatic nerves. (2008)
  • Author(s): Daisuke Tomohiro
  • Organizer: The 85th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-25
• [Presentation] 成熟ラット脊髄膠様質の興奮性シナプス伝達に及ぼすガラニンの作用 (2008)
  • Author(s): 岳海源
  • Organizer: 第30回脊髄機能診断研究会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-02-02
• [Presentation] ATP受容体の活性化による脊髄運動ニューロンの興奮 (2008)
  • Author(s): 青山貴博
  • Organizer: 第30回脊髄機能診断研究会
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-02-02
• [Presentation] オピオイドによるカエル坐骨神経の活動電位抑制とその化学構造との関連 (2007)
  • Author(s): 水田 恒太郎
  • Organizer: 生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 愛知県雄岡崎市
  • Year and Date: 2007-12-07
• [Presentation] ホスホリパーゼA2活性化を介したラット脊髄膠様質ニューロンのGABAとグリシンによる抑制性シナプス伝達の促進 (2007)
  • Author(s): 熊本栄一
  • Organizer: 生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2007-12-06
• [Presentation] ホスホリパーゼA_2活性化を介したラット脊髄膠様質ニューロンのGABAとグリシンによる抑制性シナプス伝達の促進 (2007)
  • Author(s): 熊本 栄一
  • Organizer: 生理学研究所研究会「筋・骨格系と内臓の痛み研究会」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2007-12-06
• [Presentation] TRPA1の活性化による興奮性シナプス伝達の増強 (2007)
  • Author(s): 中塚映政
  • Organizer: 生理学研究所研究会「シナプス伝達ダイナミクス解明の新戦略-シナプス伝達の細胞分子調節機構-」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2007-11-22
• [Presentation] TRPAIの活性化による興奮性シナプス伝達の増強 (2007)
  • Author(s): 中塚 映政
  • Organizer: 生理学研究所研究会「シナプス伝達ダイナミクス解明の新戦略-シナプス伝達の細胞分子調節機構-」
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2007-11-22
• [Presentation] Phospholipase A2 activation enhances inhibitory synaptic transmission in rat spinal dorsal horn neurons (2007)
  • Author(s): T. Liu
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] Tramadol presynaptically inhibits glutamatergic excitatory synaptic transmission in rat spinal dorsal horn neurons by activatingμ-opioid receptors (2007)
  • Author(s): A. Koga
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] Direct activation of postsynaptic NMDA receptors by TRPA1-induced glutamate release onto substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): T. Nakatsuka
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] Enhancement by PAR-1 activation of the spontaneous release of L-glutamate from nerve terminals in the adult rat spinal dorsal horn (2007)
  • Author(s): T. Fujita
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] Enhancement by PAR-1 activation of the spontaneous release of L-glutamate from nerve terminals in the adult rat spinal dorsal horn. (2007)
  • Author(s): Tsugumi Fujita
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] Direct activation of postsynaptic NMDA receptors by TRPAl-induced glutamate release onto substantia gelatinosa neurons of the adult rat spinal cord. (2007)
  • Author(s): Terumasa Nakatsuka
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] ramadol presynaptically inhibits glutamatergic excitatory synaptic transmission in rat spinal dorsal horn neurons by activating μ-opioid receptors. (2007)
  • Author(s): Akiko Koga
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] Phospholipase A_2 activation enhances inhibitory synaptic transmission in rat spinal dorsal hom neurons. (2007)
  • Author(s): Tao Liu
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-07
• [Presentation] Extracellular ATP facilitates excitatory synaptic transmission in rat spinal motoneurons (2007)
  • Author(s): T. Aoyama
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-05
• [Presentation] Extracellular ATP facilitates excitatory synaptic transmission in rat spinal motoneurons. (2007)
  • Author(s): Takahiro Aoyama
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-05
• [Presentation] Opioids reduce the peak amplitude of compound action potential in frog sciatic nerves. (2007)
  • Author(s): Kotaro Mizuta
  • Organizer: Society for Neuroscience 37th Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2007-11-05
• [Presentation] Inhibition by opioids of compound action potentials in frog sciatic nerves. (2007)
  • Author(s): Kotaro Mizuta
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-12
• [Presentation] Presynaptic TRPA1 activation enhances glutamate release onto substantia gelatinosa neurons of the adult rat spinal cord (2007)
  • Author(s): M. Kosugi
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-11
• [Presentation] Tramadol produces nerve conduction block in a manner independent of opioid receptor activation and monoamine uptake inhibition. (2007)
  • Author(s): Ryo Katsuki
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-11
• [Presentation] Presynaptic TRPA1 activation enhances glutamate release onto substantiagelatinosa neurons of the adult rat spinal cord. (2007)
  • Author(s): Masafumi Kosugi
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-11
• [Presentation] Enhancement by phospholipase A2 activation of glycinergic and GABAergic inhibitory transmission in rat substantia gelatinosa neurons (2007)
  • Author(s): T. Liu
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-10
• [Presentation] Enhancement by PAR-1 activation of glutamatergic excitatory transmission in adult rat substantia gelatinosa neurons (2007)
  • Author(s): T. Fujita
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-10
• [Presentation] Enhancement by PAR-1 activation of glutamatergic excitatory transmission in adult rat substantia gelatinosa neurons. (2007)
  • Author(s): Tsugumi Fujita
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-10
• [Presentation] Enhancement by phospholipase A_2 activation of glycinergic and GABAergic inhibitory transmission in rat substantia gelatinosa neurons. (2007)
  • Author(s): Tao Liu
  • Organizer: The 30th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-10
• [Presentation] Glutamate release enhancement by activating proteinase-activated receptor-1 in the adult rat substantia gelatinosa (2007)
  • Author(s): T. Fujita
  • Organizer: The 29th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-07-07
• [Presentation] TRPA1-mediated facilitation of excitatory synaptic transmission in the spinal dorsal horn (2007)
  • Author(s): M. Kosugi
  • Organizer: The 29th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-07-07
• [Presentation] Glutamate release enhancement by activating proteinase-activated receptor-1 in the adult rat substantia gelatinosa. (2007)
  • Author(s): Tsugumi Fujita
  • Organizer: The 29th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-07-07
• [Presentation] Inhibitory effects of opioids on compound action potentials in frog sciatic nerves. (2007)
  • Author(s): Kotaro Mizuta
  • Organizer: The 29th Annual Meeting of the Japanese Association for the Study of Pain
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-07-07
• [Presentation] TRPA1-mediated facilitation of excitatory synaptic transmission in the spinal dorsal horn. (2007)
  • Author(s): Masafumi Kosugi
  • Organizer: The 29th Annual Meeting of the Japanese Association for the study of Pain
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-07-07
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): E. Kumamoto, T. Liu, T. Fujita, H. -Y. Yue, T. Nakatsuka, Research Signpost, Kerala, India
  • Publisher: Ed. by E. Kumamoto
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): T. Nakatsuka, T. Fujita, E. Kumamoto, Research Signpost, Kerala, India
  • Publisher: Ed. by E. Kumamoto
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems (2007)
  • Author(s): T. Fujita, T. Nakatsuka, E. Kumamoto Research Signpost, Kerala, India
  • Publisher: Ed. by E. Kumamoto
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems, Ed. by E. Kumamoto (2007)
  • Author(s): Tsugumi Fujita
  • Publisher: Research Signpost, Kerala, India
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems, Ed. by E. Kumamoto (2007)
  • Author(s): Terumasa Nakatsuka
  • Publisher: Research Signpost, Kerala, India
• [Book] Cellular and Molecular Mechanisms for the Modulation of Nociceptive Transmission in the Peripheral and Central Nervous Systems, Ed. by E. Kumamoto (2007)
  • Author(s): Eiichi Kumamoto
  • Publisher: Research Signpost, Kerala, India
• [Remarks] 研究代表者の所属研究室のホームページ
  • URL: http://www.neurophysiology.med.saga-u.ac.jp