Regulation of burst activity through GABAB receptors in mouse superior colliculus

• Project/Area Number: 19700361
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: KANEDA Katsuyuki National Institute for Physiological Sciences, 発達生理学研究系, 助教 (30421366)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,340,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: 上丘 / バースト発火 / サッケード / GABA作動性ニューロン / GABAB受容体 / 局所神経回路

Research Abstract

中脳に位置する上丘は、興味の対象にすばやく視線を向ける眼球サッケード運動制御の中枢である。本研究ではマウスのスライス標本を用いてサッケード運動に先行して生成される上丘ニューロンのバースト発火がどのように終了するのかについて解析し、GABAB受容体が重要な役割を果たしていることを明らかにした。この結果は、眼球運動が適切に終了するためにはGABAB受容体の機能が重要であることを示唆している。

Research Products

• [Journal Article] Regulation of burst activity through presynaptic and postsynaptic GABA receptors in mouse superior colliculus (2008)
  • Author(s): Kaneda K, Phongphanphanee P, Katoh T, Isa K, Yanagawa Y, Obata K, Isa T.
  • Journal Title: B J Neurosci. 28(4) Pages: 816-27
  • Peer Reviewed
• [Journal Article] Spatiotemporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording (2008)
  • Author(s): Phongphanphanee P, Kaneda K, Isa T.
  • Journal Title: J Neurosci. 28(37) Pages: 9309-18
  • Peer Reviewed
• [Journal Article] Nigral inhibition of GABAergic neurons in mouse superior colliculus (2008)
  • Author(s): Kaneda K, Isa K, Yanagawa Y, Isa T.
  • Journal Title: J Neurosci. 28(43) Pages: 11071-8
  • Peer Reviewed
• [Journal Article] Nigral inhibition of GABAergic neurons in mouse superior colliculus (2008)
  • Author(s): Kaneda, et.al.
  • Journal Title: J Neurosci. 28 Pages: 11071-11078
  • Peer Reviewed
• [Journal Article] Spatiotemporal profiles of field potentials in mouse superior colliculus analyzed by multichannel recording (2008)
  • Author(s): Phongphanphanee, et.al.
  • Journal Title: J Neurosci. 28 Pages: 9309-9318
  • Peer Reviewed
• [Journal Article] Dendritic Ih ensures high-fidelity dendritic spike responses of motion-sensitive neurons in rat superior colliculus (2008)
  • Author(s): Endo, et.al.
  • Journal Title: J Neurophysiol. 99 Pages: 2066-2076
  • Peer Reviewed
• [Journal Article] Regulation of burst activity through presynaptic and postsynaptic GABA_B receptors in mouse superior colliculus. (2008)
  • Author(s): Kaneda K., et. al.
  • Journal Title: J Neurosci. 28 Pages: 816-827
  • Peer Reviewed
• [Journal Article] Dendritic Ih Ensures High-fidelity Dendritic Spike Responses of Motion Sensitive Neurons in Rat Superior Colliculus.
  • Author(s): Endo T., et. al.
  • Journal Title: J Neurophysiol. (印刷中)
  • Peer Reviewed
• [Presentation] マウス上丘局所GABA作動性ニューロンによるwide-field vertical cellの活動制御機構 (2008)
  • Author(s): 金田勝幸
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 東京
• [Presentation] Feedforward inhibition by local GABAergic neurons regulates activity of wide-field vertical cells in mouse superior colliculus (2008)
  • Author(s): Kaneda, K.
  • Organizer: 38^<th> Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington, DC, USA
• [Presentation] GABAB receptor-mediated inhibition of burst activities in mouse superior colliculus in vitro (2007)
  • Author(s): 金田勝幸
  • Organizer: 第32回北米神経科学学会
  • Place of Presentation: サンディエゴ、米国
• [Presentation] Mechanisms of GABAB receptor-mediated inhibition of burst activities in mouse superior colliculus (2007)
  • Author(s): 金田勝幸
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] GABAB receptor-mediated feedback inhibition of burst firings in the superior colliculus (2007)
  • Author(s): 金田勝幸
  • Organizer: 第84回日本生理学会大会
  • Place of Presentation: 大阪
• [Presentation] 黒質網様部から上丘中間層GABA作動性ニューロンへの抑制性入力 (2007)
  • Author(s): 金田勝幸
  • Organizer: 第22回日本大脳基底核研究会
  • Place of Presentation: 旭川
• [Presentation] マウス上丘でのGABA_B受容体によるバースト発火の制御機構 (2007)
  • Author(s): 金田勝幸
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] 黒質網様部から上丘中間層GABA作動性ニューロンへの抑制性入力 (2007)
  • Author(s): 伊佐かおる
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] The origin of spreading burst activities in the local circuit of the superi or colliculus. (2007)
  • Author(s): フォンファンファニー ペンフィモン
  • Organizer: 第30回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] GABA_B receptor-mediated inhibition of burst activities in mouse superior colliculus in vitro (2007)
  • Author(s): Kaneda, K.
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] Direct nigral inhibitory inputs to GABAergic neurons in mouse superior colliculus. (2007)
  • Author(s): Yanagawa, Y.
  • Organizer: 37th Annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Book] 見たいものに視線をとめる役割をGABAがになう? (2008)
  • Author(s): 金田勝幸、伊佐正
  • Publisher: オーム社
• [Remarks]
  • URL: http://www.nips.ac.jp/hbfp/
• [Remarks]
  • URL: http://www.nips.ac.jp/
• [Remarks] 統合脳
  • URL: http://www.togo-nou.nips.ac.jp/