The mechanism of atherosclerotic plaque disruption in apoE-deficient mice. The concept of the involvement of inflammation
| Project/Area Number |
19700366
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SASAKI Takeshi Hamamatsu University School of Medicine, 技術部, 技術専門職員 (20397433)
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| Research Collaborator |
KUZUYA Masafumi 名古屋大学大学院, 医学系研究科, 准教授 (10283441)
CHENG Xian Wu 名古屋大学, 医学部, 講師 (30378228)
NAKAMURA Kae ミシガン大学, Cardiovasc center, 研究員
SUZUKI Tohru 浜松医科大学, 医学部, 助教 (10362188)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,650,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | プラーク破綻 / 動脈硬化 / 炎症性細胞 / 細胞外マトリクッス / MMPs / 動脈硬化症 / 実験動物モデル / 炎症反応 / マクロファージ / 好中球 / MMP / カテプシン |
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| Research Abstract |
心筋梗塞や脳梗塞は、血管の肥厚内膜が破れるプラーク破綻(破裂)が引き金になるとされているが、このプラーク破綻のメカニズムは不明のままである。研究代表者の佐々木は、マウスを用いたプラーク破綻モデルを作成し、そのメカニズムの解明を試みた。その結果、このマウスモデルにおけるプラーク破綻には、病変部に集積する炎症細胞(マクロファージ、好中球等)と、それらの細胞が放出するプロテアーゼが重要であることを明らかにした。
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Report
(3 results)
Research Products
(52 results)
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[Journal Article] Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type I receptor blocker treatment.2008
Author(s)
Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M.
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Journal Title
Am J Pathol 173
Pages: 358-369
Related Report
Peer Reviewed
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[Journal Article] Irradiation in adulthood as a new model of schizophrenia.2008
Author(s)
Iwata Y, Suzuki K, Wakuda T, Seki N, Thanseem I, Matsuzaki H, Mamiya T, Ueki T, Mikawa S, Sasaki T, Suda S, Yamamoto S, Tsuchiya KJ, Sugihara G, Nakamura K, Sato K, Takei N, Hashimoto K, Mori N.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Mechanisms underlying the impairment of ischemia-induced neovascularization in matrix metalloproteinase 2-deficient mice.2007
Author(s)
Cheng XW, Kuzuya M, Nakamura K, Maeda K, Tsuzuki M, Kim W, Sasaki T, Liu Z, Inoue N, Kondo T, Jin H, Numaguchi Y, Okumura K, Yokota M, Iguchi A, Murohara T
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Journal Title
Circ Res 100
Pages: 904-913
Related Report
Peer Reviewed
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[Presentation] Azelnidipine Enhances Beneficial Effects of Olmesartan on Left Ventricular Remodeling During the Development of Hypertension-induced Heart Failure2008
Author(s)
Cheng XW, Okumura K, Kuzuya M, Inoue A, Sasaki T, Nakamura K, Song H, Li P, Nagata K, Sato K, Murohara T.
Organizer
第31回日本高血圧学会総会日中高血圧シンポジウム
Place of Presentation
札幌
Related Report
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[Presentation] Superoxide-Dependent Activation of Cysteine Protease Cathepsin System is Associated with Hypertensive Myocardial Remodeling and Represents a Target for Angiotesin II Type 1 Receptor Blocker Therapy.2007
Author(s)
Cheng XW, Okumura K, Kuzuya M, Nagata K, Obata K, Inoue K, Sasaki T, Nishizawa T, Izawa H, Yamata T, Kobayashi M, Murohara T, Yokota M.
Organizer
American Heart Association, Scientific Sections
Place of Presentation
Orlando, Florida
Related Report
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