Deep-tissue optical imaging using ultrasonic interference

• Project/Area Number: 19700384
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YAMAOKA Yoshihisa Kyoto Prefectural University of Medicine, 医学研究科, 助教 (80405274)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,570,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,400,000 (Direct Cost: ¥2,400,000)
• Keywords: 生体光計測 / レーザ顕微鏡 / 深部イメージング / 血管イメージング / 超音波干渉 / 多光子顕微鏡 / 光散乱 / 超音波

Research Abstract

生体深部組織の視感度(visibility)向上のために、光と超音波の特徴を利用した新しいイメージング技術を提案した。この方法は、光の高コントラスト特性、高空間分解特性と、超音波の生体内長距離伝播特性、生体内屈折率平滑化とにより可能となる。光の生体ダミーとラット腸間膜血管を用いた実験結果から、従来法に比べて生体深部における深さ方向visibility向上が可能であることが明らかとなった。

Research Products

• [Journal Article] Enhancement of multiphoton excitation-induced photoacoustic signals by using gold nanoparticles surrounded by fluorescent dyes, (2009)
  • Author(s): Yamaoka Y, Takamatsu T,
  • Journal Title: Proc. SPIE 7177
  • Peer Reviewed
• [Journal Article] Enhancement of multiphoton excitation-induced photoacoustic signals by using gold nanoparticles surrounded by fluorescent dyes (2009)
  • Author(s): Yamaoka Y, Takamatsu T
  • Journal Title: Proc. SPIE 7177
  • Peer Reviewed
• [Journal Article] Mucosal layer as major source of green autofluorescence in the colon under excitation by blue light (2008)
  • Author(s): Nakano K, Harada Y, Yamaoka Y, Miyawaki K, Wakabayashi N, Mitsufuji S, Imaizumi K, Takaoka H, Nakaoka M, Takamatsu T
  • Journal Title: Proc. SPIE 6853
  • Peer Reviewed
• [Journal Article] Mucosal layer as major source of green autofluorescence in the colonunder excitation by blue light (2008)
  • Author(s): Nakano K, Harada Y, Yamaoka Y, Miyawaki K, Wakabayashi N, Mitsufuji S, Imaizumi K, Takaaka H, Nakaoka M, Takamatsu T
  • Journal Title: Proceedings of SPIE 6853
  • Peer Reviewed
• [Journal Article] Report of European Conference on Biomedical Optics 2007 (2007)
  • Author(s): Ishii K, Yamaoka Y, Kushibiki T, Awazu K
  • Journal Title: The reviews of Laser Engineering 35 Pages: 602-605
  • NAID: 10019843931
• [Journal Article] Improvement of depth resolution on photoacoustic imaging using multiphoton absorption, (2007)
  • Author(s): Yamaoka Y, Fujiwara K, Takamatsu T
  • Journal Title: Proc. SPIE 6631
  • Peer Reviewed
• [Journal Article] Improvement of depth resolution on photoacoustic imaging using multiphoton absorption (2007)
  • Author(s): Yamaoka Y, Fujiwara K, Takamatsu T
  • Journal Title: Proceedings of SPIE 6631
  • Peer Reviewed
• [Journal Article] Report of European Coference on Biomedical Optics 2007 (2007)
  • Author(s): Isbii K, Yamaoka Y, Kusbibiki T, Awazu K
  • Journal Title: The reviews of Laser Engilleering 35 Pages: 602-605
• [Presentation] Enhancement of multiphoton excitation-induced photoacoustic signals by using gold nanoparticles surrounded by fluorescent dyes (2009)
  • Author(s): Yamaoka Y, Takamatsu T
  • Organizer: Photonics West 2009
  • Place of Presentation: サンノゼ
  • Year and Date: 2009-01-26
• [Presentation] ラット大腸自家蛍光発生機序の解析 (2008)
  • Author(s): 原田義規、中野圭明、山岡禎久、高松哲郎
  • Organizer: 第49回日本組織細胞化学会総会・学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-10-06
• [Presentation] FLIMを用いた生体機能解析 (2008)
  • Author(s): 山岡禎久、今泉克一、原田義規、高松哲郎
  • Organizer: 第49回日本組織細胞化学会総会・学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-10-06
• [Presentation] ラット正常大腸自家蛍光特性の解析 (2008)
  • Author(s): 原田義規、中野圭明、山岡禎久、宮脇喜一郎、今泉克一、高岡秀行、中岡正哉、高松哲郎
  • Organizer: 第97回日本病理学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2008-05-16
• [Presentation] Analysis of the origin of autofluorescence in the rat colon by using combined SHG and two-photon microscopy (2008)
  • Author(s): Harada Y, Nakano K, Yamaoka Y, Miyawaki K, Imaizumi K, Takaoka H, Nakaoka M, Takamatsu T
  • Organizer: Focus on Microscopy 2008
  • Place of Presentation: 淡路
  • Year and Date: 2008-04-15
• [Presentation] Analysis of the origin of autofluorescence in the rat colon by using combined SHG and two-photon microscopy (2008)
  • Author(s): Harada Y, Nakano IC, Yamaoka Y, Miyawaki K, Imaizumi K, Takaoka H, Nakaoka M, Takamatsu T
  • Organizer: Focus on Microscopy 2008
  • Place of Presentation: 淡路市
  • Year and Date: 2008-04-15
• [Presentation] Improvement of depth resolution on photoacoustic imaging using multiphoton absorption (2007)
  • Author(s): Yamaoka Y, Fujiwara K, Takamatsu T
  • Organizer: European Conference on Biomedical Optics 2007
  • Place of Presentation: ミュンヘン
  • Year and Date: 2007-06-17
• [Presentation] Improvement of depth resolution on photoacoustic imaging using multip hoton absorption (2007)
  • Author(s): Yamaoka Y, Fujiwara K, Takamatsu T
  • Organizer: European Conference on Biomedical Optics 2007
  • Place of Presentation: ドイツ、ミュンヘン
  • Year and Date: 2007-06-17
• [Book] ナノイメージング (2008)
  • Author(s): 山岡禎久(分担執筆)
  • Publisher: エヌ・テイー・エス
• [Book] ナノイメージング(2008年2月出版予定)(第1章、第1節) (2008)
  • Author(s): 山岡 禎久(分担執筆)
  • Total Pages: 9
  • Publisher: エヌ・テイー・エス(株)
• [Patent(Industrial Property Rights)] 診断支援装置 (2009)
  • Inventor(s): 高松哲郎、山岡禎久、今泉克一
  • Industrial Property Rights Holder: オリンパスメディカルシステムズ株式会社
  • Industrial Property Number: 2009-085569
  • Filing Date: 2009-03-31
• [Patent(Industrial Property Rights)] 光音響断層撮影装置及び光音響断層撮影方法 (2007)
  • Inventor(s): 高松哲郎、山岡禎久
  • Industrial Property Rights Holder: 関西TLO株式会社
  • Industrial Property Number: 2007-556801
  • Filing Date: 2007-01-31