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Development of new diagnostics and therapeutics of peritoneal dialysate patients by direct measurement of nitric oxide measurement.

Research Project

Project/Area Number 19700392
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionKawasaki University of Medical Welfare

Principal Investigator

TAKAYAMA Aya  Kawasaki University of Medical Welfare, 医療技術学部, 講師 (60413514)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,710,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords生体工学 / 生体情報計測 / 腹膜透析(CAPD) / 一酸化窒素 / NOセンサ / 透析液 / 一酸化窒素(NO) / 血液透析 / 酸化ストレス / 腹膜透析
Research Abstract

長期の持続式携帯腹膜透析(CAPD)患者の腹膜機能障害の原因として、一酸化窒素(NO)の関与が推測されているが、いまだ明らかではない。今回、CAPD透析液排液中のNO濃度について、NOセンサによる直接計測を検討し安定した計測結果が得ることができた。結果、透析液中に計測され得るレベルでNOが存在すること、患者によって透析液中NO濃度に大きな差があることなどが明らかとなり、CAPD透析液中NOと計測した関連物質の面から、長期CAPD時の腹膜機能変化メカニズムにおけるNOの関与の解明およびCAPD患者の腹膜機能の定量的評価が可能になり得るものと考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2009 2008 2007

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Direct measurement of nitric oxide concentration in CAPD dialysate2009

    • Author(s)
      Seiichi Mochizuki, Aya Takayama, Tamaki Sasaki, et al
    • Journal Title

      Perit. Dial. Int 29(1)

      Pages: 111-114

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] CAPD透析液中NO濃度の直接計測と関連物質の関与の検討2008

    • Author(s)
      高山綾
    • Journal Title

      日本透析医学会雑誌 第41巻

      Pages: 519-519

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 腹膜透析液中NOと関連物質の動態評価2007

    • Author(s)
      高山綾、望月精一、矢田豊隆、小笠原康夫、他
    • Journal Title

      電子情報通信学会技術研究報告IEICE Technical Report MBE2007-42 vol.107,No.154

      Pages: 87-90

    • NAID

      110006380714

    • Related Report
      2008 Final Research Report
  • [Journal Article] 腹膜透析液中NOと関連物質の動態評価2007

    • Author(s)
      高山 綾
    • Journal Title

      信学技報IEICE Technical Report Vol.157,No.154

      Pages: 107154-107154

    • NAID

      110006380714

    • Related Report
      2007 Annual Research Report
  • [Presentation] CAPD透析液中NO濃度の直接計測と関連物質の関与の検討2008

    • Author(s)
      高山綾、望月精一、矢田豊隆、佐々木環、ほか
    • Organizer
      第53回日本透析医学会学術集会総会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] CAPD透析液中NO濃度の直接計測と関連物質の関与の検討2008

    • Author(s)
      高山綾
    • Organizer
      第53回日本透析医学会学術集会総会(神戸)
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Direct Measurement of Nitric Oxide and Tetrahydrobiopterin Levels in Peritoneal Dialysate2007

    • Author(s)
      TAKAYAMA AYA, Mochizuki Seiichi, Sasaki Tamaki, et al
    • Organizer
      The 3rd Asian Chapter Meeting of the International Society for Peritoneal Dialysis
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2007-11-23
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 腹膜透析液中NOと関連物質の動態評価2007

    • Author(s)
      高山綾、望月精一、矢田豊隆、小笠原康夫ほか
    • Organizer
      2007 Joint Congress of "the 45thAnnual Meeting of the Japanese Society for Artificial Organs and the 2nd Meeting of the International Federation for Artificial Organs
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 腹膜透析液中NOと関連物質の動態評価2007

    • Author(s)
      高山 綾
    • Organizer
      The 45thAnnual Meeting of the Japanese Society for Artificial Organs and the 2nd Meeting of the International Federation for Artificial Organs
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2007-10-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 腹膜透析液中NOと関連物質の動態評価2007

    • Author(s)
      高山綾、望月精一、矢田豊隆、小笠原康夫、ほか
    • Organizer
      日本生体医工学会MEとバイオサイバネティクス研究会
    • Place of Presentation
      徳島大学
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 腹膜透析液中NOと関連物質の動態評価2007

    • Author(s)
      高山 綾
    • Organizer
      電子情報通信学会 MEとバイオサイバネティックス
    • Place of Presentation
      徳島大学
    • Year and Date
      2007-07-21
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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