Numerical simulation in small airways and alveolar models during rhythmical airway motion

• Project/Area Number: 19700394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SERA Toshihiro The Institute of Physical and Chemical Research, 生体力学シミュレーションチーム, 協力研究員 (40373526)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,170,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: CT / 細気管支 / 肺胞 / 気流シミュレーション / 数値計算 / 放射光 / 気管支 / 動態解析 / 4D-CT / 流体解析

Research Abstract

従来、気道末梢部位での気流速度が小さいため、末梢部位での物質輸送は主に分子拡散によるものと考えられてきた。しかし、末梢気道の幾何形状は中枢気道とは大きく異なり、複雑に分岐を繰り返していて、さらに呼吸に伴って大変形する。本研究では、高分解能CTを用いて末梢気道の動態解析を行い、さらに数値計算の手法によって生体内での末梢気道系の物質輸送について検討した。その結果、気道壁の変形によって、末梢気道内のガス・粒子輸送が促進されていることが分かった。

Research Products

• [Journal Article] 小動物用高分解能in vivo-CTシステムの開発-生きた小動物の心臓や肺の動きを捉える- (2009)
  • Author(s): 世良俊博
  • Journal Title: 光アライアンス 20(5) Pages: 27-31
  • NAID: 40016650806
• [Journal Article] Development of high resolution 4D in vivo-CT for visualization of cardiac and respiratory deformations of small animals (2008)
  • Author(s): Toshihiro SERA, Hideo YOKOTA, Kazuhiro FUJISAKI, Hiroyuki TACHIBANA, Kentaro UESUGI, Naoto YAGI, Ryutaro HIMENO
  • Journal Title: Physics in Medicine and Biology 53(16) Pages: 4285-4301
  • Peer Reviewed
• [Journal Article] High-Resolution Visualization of Tumours in Rabbit Lung using Refraction Contrast X-ray Imaging (2008)
  • Author(s): T SERA, K. UESUGI, N. YAGI, K. UMETANI, M. KOBATAKE, S. IMAI
  • Journal Title: European Journal of Radiology 68(3 Suppl) Pages: 54-57
  • Peer Reviewed
• [Journal Article] High-resolution 4D in vivo-CT for visualization of cardiovascular and respiratory motion of small animals (2008)
  • Author(s): T Sera
  • Journal Title: SPring-8 Research Frontiers (in press)
• [Journal Article] Development of high resolution 4D in vivo-CT for visualization of cardiac and respiratory motion of small animals (2008)
  • Author(s): Toshihiro Sera
  • Journal Title: Physics in Medicine and Biology 53 Pages: 4285-4301
  • Peer Reviewed
• [Journal Article] High-Resolution Visualization of Tumours in Rabbit Lung using Refraction Contrast X-ray Imaging (2008)
  • Author(s): Toshihiro Sera
  • Journal Title: European Journal of Radiology 68 Pages: 54-57
  • Peer Reviewed
• [Journal Article] In vivo-CT system with respiratory and cardiac gating using synchrotron radiation (2007)
  • Author(s): Toshihiro SERA, Hideo YOKOTA, Kazuhiro FUJISAKI, Kazuaki FUKASAKU, Kentaro UESUGI, Naoto YAGI, Ryutaro HIMENO
  • Journal Title: Conf SPIE Medical Imaging 6512 Pages: 301-309
  • Peer Reviewed
• [Journal Article] Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation (2007)
  • Author(s): Toshihiro SERA, Kentaro UESUGI, Ryutaro HIMENO, Naoto YAGI
  • Journal Title: Respiratory Physiology & Neurobiology 156(3) Pages: 304-11
  • Peer Reviewed
• [Journal Article] Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation. (2007)
  • Author(s): Toshihiro SERA
  • Journal Title: Respir Physiol Neurobiol. 156 Pages: 304-11
  • Peer Reviewed
• [Journal Article] 気道末梢部位のイメージングと気流解析
  • Author(s): 世良俊博, 横田秀夫, 上杉健太郎, 八木直人
  • Journal Title: 可視化情報学会誌 (印刷中)
• [Presentation] 実形状末梢気道内の気流シミュレーション (2009)
  • Author(s): 世良俊博
  • Organizer: 日本機械学会第21回バイオエンジニアリング講演会
  • Place of Presentation: 札幌
  • Year and Date: 2009-01-23
• [Presentation] 実形状末梢気道内の気流シミュレーション (2009)
  • Author(s): 世良俊博, 計4名
  • Organizer: 第21回日本機械学会バイオエンジニアリング講演会
  • Place of Presentation: 北海道
• [Presentation] 末梢気道系の動態解析と気流シミュレーション (2009)
  • Author(s): 世良俊博, 計6名
  • Organizer: 理研シンポジウム
  • Place of Presentation: 埼玉
• [Presentation] Reconstruction of realistic deformation model to simulate airflow in small airways (2008)
  • Author(s): Toshihiro Sera
  • Organizer: BMES 2008 Annual Fall Meeting
  • Place of Presentation: St. Louis
  • Year and Date: 2008-10-02
• [Presentation] 肺の3D・4Dイメージング (2008)
  • Author(s): 世良俊博, 計7名
  • Organizer: 理研シンポジウム
  • Place of Presentation: 埼玉
• [Presentation] 放射光CTを用いた気管支動態解析 (2008)
  • Author(s): 世良俊博, 計6名
  • Organizer: 日本生体医工学会
  • Place of Presentation: 兵庫
• [Presentation] 肺の3D・4Dイメージング (2008)
  • Author(s): 世良俊博
  • Organizer: SPring8ワークショップ-高度X線イメージング材料科学の展開-
  • Place of Presentation: 兵庫
• [Presentation] 気道末梢部位での呼吸シミュレーション (2008)
  • Author(s): 世良俊博
  • Organizer: ANSYS conference
  • Place of Presentation: 東京
• [Presentation] Reconstruction of realistic deformation model to simulate airflow in small airways (2008)
  • Author(s): T sera, et al.
  • Organizer: 2008 BMES Annual Fall Meeting
  • Place of Presentation: USA
• [Presentation] In vivo microtomography for cardiovascular and respiratory system (2008)
  • Author(s): T sera, et al.
  • Organizer: 1st Workshop on Micro- and Nano-tomography
  • Place of Presentation: Japan
• [Presentation] Development of 4-D high-resolution CT for measurement of airway deformation (2007)
  • Author(s): 世良俊博
  • Organizer: ASME Bioengineering Conference
  • Place of Presentation: Colorado, USA
  • Year and Date: 2007-06-23
• [Presentation] 放射光を用いた小動物用in vivo-CTの開発 (2007)
  • Author(s): 世良俊博
  • Organizer: 日本生体医工学会大会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2007-04-25
• [Presentation] シンクロトロン放射光を用いたin vivo-CTの開発 (2007)
  • Author(s): 世良俊博, 計7名
  • Organizer: 第19回日本機械学会バイオエンジニアリング講演会
  • Place of Presentation: 仙台
• [Presentation] 放射光を用いた小動物用in vivo-CTの開発 (2007)
  • Author(s): 世良俊博, 計7名
  • Organizer: 日本生体医工学会
  • Place of Presentation: 仙台
• [Presentation] In vivo CT system with respiratory and cardiac gating using synchrotron radiation (2007)
  • Author(s): T sera, et al.
  • Organizer: SPIE Medical Imaging
  • Place of Presentation: USA
• [Presentation] Development of 4-D high-resolution CT for measurement of airway deformation (2007)
  • Author(s): T sera, et al.
  • Organizer: ASME Bioengineering Conference
  • Place of Presentation: USA
• [Presentation] High-resolution visualization of tumors in rabbit lung using refraction contrast X-ray imaging (2007)
  • Author(s): T sera, et al.
  • Organizer: Medical Applications of Synchrotron Radiation
  • Place of Presentation: Canada
• [Remarks] 高輝度放射光を光源にした小動物用高分解能in vivo-CTシステムを開発
• [Remarks] RIKEN RESEARCH 12月号
• [Remarks] 化学工業日報2008年8月12日
• [Remarks] 日経産業新聞2008年8月13日
• [Remarks] フジサンケイアイ2008年8月21日
• [Remarks] Laser Focus World Japan 9月号