System of Image processing for quantitative brain PET images

• Project/Area Number: 19700395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: SHIDAHARA Miho National Institute of Radiological Sciences, 分子イメージング研究センター, 研究員 (20443070)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,970,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 核医学 / ウェーブレット

Research Abstract

本研究は、陽電子断層撮影(PET)を用いた脳神経受容体機能定量画像の高精度化を目指し、ガウシアンノイズ除去及び部分容積効果補正に関してシステムを構築しその有用性を数値シミュレーションで実証した。また、これらの技術が必要とされている臨床例(脳内ドーパミンD2受容体結合能や脳萎縮が進行したアルツハイマー病患者の糖代謝画像など)への適応を行い、その有用性を確認した。

Research Products

• [Journal Article] Improvement of likelihood estimation in Logan graphical analysis using Maximum A Posteriori for Neuroreceptor PET Imaging (2009)
  • Author(s): Shidahara Miho, Seki Chie, Naganawa Mika, sakata Muneyuki, Ishikawa Masatomo, Ito Hiroshi, Kanno Iwao, Ishiawata Kiichi, Kimura Yuichi
  • Journal Title: Annals of Nuclear Medicine 23巻2号 Pages: 163-171
  • NAID: 10025135723
  • Peer Reviewed
• [Journal Article] unctional and structural synergy for resolution recovery and partial volume correction in brain PET (2009)
  • Author(s): Shidahara Miho, Tsoumpas Chalalmpous, Hammers Alexander, Boussion Nicolas, Visvikis Dimitris, Suhara Tetsuya, Kanno Iwao, Turkheimer E Federico
  • Journal Title: Neuroimage 44巻2号 Pages: 340-348
  • Peer Reviewed
• [Journal Article] Functional and structural synergy for resolution recovery and partial volume correction in brain PET (2009)
  • Author(s): Miho Shidahara
  • Journal Title: Neuroimage 44(2) Pages: 340-348
  • Peer Reviewed
• [Journal Article] Improvement of likelihood estimation in Logan graphical analysis using maximum a posteriori for neuroreceptor PET imaging (2009)
  • Author(s): Miho Shidahara
  • Journal Title: Annals of Nuclear Medicine 23(2) Pages: 163-171
  • NAID: 10025135723
  • Peer Reviewed
• [Journal Article] ptimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rate (2008)
  • Author(s): Shidahara Miho, Watabe Hiroshi, Kim KyoengMin, Kudomi Nobuyuki, Ito Hiroshi, Iida Hidehiro
  • Journal Title: Annals of Nuclear Medicine 22巻8号 Pages: 667-675
  • Peer Reviewed
• [Journal Article] No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study (2008)
  • Author(s): Ito Hiroshi, Arakawa Ryosuke, Takahashi Hidehiko, Takano Harumasa, Okumura Masaki, Otsuka Tatsui, Ikma Yoko, Shidahara Miho, Suhara Tetsuya
  • Journal Title: International Journal of Neuropsychopharmacology 21巻 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457 (2008)
  • Author(s): Ikoma Yoko, Ito Hiroshi, Arakawa Ryosuke, Okumura Masaki, Seki Chie, Shidahara Miho, Takahashi Hidehiko, Kimura Yuichi, Kanno Iwao, Suhara Tetsuya
  • Journal Title: Neuroimage 42巻4号 Pages: 1285-1294
  • Peer Reviewed
• [Journal Article] Wavelet denoising for voxel-based compartment analysis of peripheral benzodiazepine receptors with F-FEDAA1106 (2008)
  • Author(s): Shidahara Miho, Ikoma Yoko, Fujimura Yota, Seki Chie, Naganawa Mika, Ito Hiroshi, Suhara Tetsuya, Kanno Iwao, Kimura Yuichi
  • Journal Title: European Journal of Nuclear Medicine Molecular Imaging 35巻2号 Pages: 416-423
  • Peer Reviewed
• [Journal Article] PET kinetic analysis: error consideration of quantitative analysis in dynamic studies (2008)
  • Author(s): Ikoma Yoko, Watabe Hiroshi, Shidahara Miho, Naganawa Mika, Kimura Yuichi
  • Journal Title: Annals of Nuclear Medicine 22巻1号 Pages: 1-11
  • NAID: 10021279983
  • Peer Reviewed
• [Journal Article] Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rate (2008)
  • Author(s): Miho Shidahara
  • Journal Title: Annals of Nuclear Medicine 22(8) Pages: 667-675
  • NAID: 10024456520
  • Peer Reviewed
• [Journal Article] Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with 18F-FEDAA1106 (2008)
  • Author(s): Miho Shidahara
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging 35 Pages: 416-423
  • Peer Reviewed
• [Journal Article] PET kinetic analysis:Wavelet denoising of dynamic PET Data with Application to Parametric Imaging (2007)
  • Author(s): Shidahara Miho, Ikoma Yoko, Kershaw Jeffery, Kimura Yuichi, Naganawa Mika, Watabe Hiroshi
  • Journal Title: Annals of Nuclear Medicine 21巻7号 Pages: 379-386
  • Peer Reviewed
• [Journal Article] Body-contour versus circular orbit acquisition in cardiac SPECT: assessment of defect detectability with channelized Hotelling observer (2007)
  • Author(s): Solberg Antti, Watabe Hiroshi, Shidahara Miho, Iida Hidehiro
  • Journal Title: Nuclear Medicine Communication 28巻12号 Pages: 937-942
  • Peer Reviewed
• [Journal Article] Mapping of central dopamine synthesis in man, using positron emission tomography with L-[beta-11C]DOPA (2007)
  • Author(s): Ito Hiroshi, Shidahara Miho, Takano Harumasa, Takahashi Hidehiko, Nozaki Shoko, Suhara Tetsuya
  • Journal Title: Annals of Nuclear Medicine 21巻7号 Pages: 355-360
  • Peer Reviewed
• [Journal Article] PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging (2007)
  • Author(s): Miho Shidahara
  • Journal Title: Ammals of Nuclear Medicine 21 Pages: 379-386
  • NAID: 10019946076
  • Peer Reviewed
• [Presentation] MAP estimation in Logan Graphical Analysis for Neuroreceptor PET Imaging (2008)
  • Author(s): Miho Shidahara
  • Organizer: The 55^<th> Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2008-06-15
• [Presentation] Parametric Imaging of the Total Volume of Distribution using MAP Estimation for Logan Graphical Analysis (2008)
  • Author(s): Shidahara Miho, Kimura Yuichi, Seki Chie, Naganawa Mika, Sakata Muneyuki, Ito Hiroshi, Suhara Tetsuya, Ishiwata Kiichi, Kanno Iwao
  • Organizer: NeuroReceptor Mapping 2008
  • Place of Presentation: Pittsburg, USA
• [Presentation] MAP Estimation in Logan Graphical Analysis for Neuroreceptor PET Imaging (2008)
  • Author(s): Shidahara Miho, Seki Chie, Naganawa Mika, Sakata Muneyuki, Ito Hiroshi, Kanno Iwao, Ishiwata Kiichi, Kimura Yuichi
  • Organizer: The 55th Annual Meeting of the Society of Nuclear Medicine
  • Place of Presentation: New Orleans, USA
• [Presentation] Wavelet denoising for parametric imaging of the peripheral benzodiazepine receptors with 18F-FEDAA1106 (2007)
  • Author(s): Shidahara Miho, Kimura Yuichi, Seki Chie, Ikoma Yoko, Fujimura Yota, Ito Hiroshi, Suhara Tetsuya, Kanno Iwao
  • Organizer: Brain'07 and BrainPET'07
  • Place of Presentation: 大阪