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Identification of mechanical stimulation to promote osteoanagenesis by a unique three-dimensional scaffold

Research Project

Project/Area Number 19700399
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku University

Principal Investigator

MASUDA Taisuke  Tohoku University, 大学院歯学研究科, 助教 (30431513)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥570,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
Keywords再生医工学材料 / メカニカルストレス / 3次元培養 / 骨芽細胞 / 軟骨細胞 / エラストマー担体 / 細胞間相互作用 / 有限要素解析 / 硬組織再生担体 / リン酸オクタカルシウム / 細胞・組織工学
Research Abstract

本研究は,生体内のストレス環境を模倣した培養システム(メカニカルスティミュレータ)の開発と規則的構造体を有する3次元エラストマー成担体の開発を通して,力学刺激量とそれに対する細胞の増殖・分化誘導条件の最適化を目指した.未分化骨芽細胞を用いた培養の結果,圧縮ひずみ下においてCol1およびOPNの遺伝子発現が抑制されることがわかった.このことからメカニカルストレスによる分化調節・分化維持の可能性が示唆される.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Molecular Mechanisms of mechanical Stress Response during Chondrogenesis2009

    • Author(s)
      I. Takahashi, T. Masuda, et al.
    • Journal Title

      Journal of Boimechanical Science and Engineerng 4(印刷中)

    • NAID

      130000129002

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Mechanisms of mechanical Stress Response during Chondrogenesis2009

    • Author(s)
      Ichiro Takahashi, Taisuke Masuda, et.al.
    • Journal Title

      Journal of Biomechanical Science and Engineering Vol.4, No.3(印刷中)

    • NAID

      130000129002

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 局所環境が硬組織形成細胞の分化に及ぼす影響について2008

    • Author(s)
      鈴木治, 益田泰輔, 高橋一郎
    • Journal Title

      生体医工学 46

      Pages: 414-418

    • NAID

      110006989895

    • Related Report
      2008 Annual Research Report 2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of cell culture system loading cyclic mechanical strain to chondrogenic cells2008

    • Author(s)
      T. Masuda, I. Takahashi, et al.
    • Journal Title

      J. Biotechnol 133

      Pages: 231-238

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of cell culture system loading cyclic mechanical strain to chondrogenic cells2008

    • Author(s)
      Taisuke Masuda
    • Journal Title

      Journal of Biotechnology 133

      Pages: 231-238

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of PDMS scaffold with controlled configuration2007

    • Author(s)
      Taisuke Masuda
    • Journal Title

      Proceedings of 2007 International Symposium on Micro-Nano Mechatronics and Human Science

      Pages: 362-367

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of Mechanical Strain on Differentiation of Osteoblastic Cells2008

    • Author(s)
      A Mastui, et al.
    • Organizer
      2008 International Symosium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-11-08
    • Related Report
      2008 Final Research Report
  • [Presentation] Effects of Mechanical Strain on Differentiation of Osteoblastic Cells2008

    • Author(s)
      Aritsune Matsui
    • Organizer
      2008 International Symposium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Nagoya
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] Characterization of Three-Dimensional Elastomer Scaffolds for Mechanical Stimulation Culture2008

    • Author(s)
      T. Masuda, et al.
    • Organizer
      8th World Biomaterials Congress
    • Place of Presentation
      Amsterdam
    • Year and Date
      2008-05-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Characterization of Three-Dimensional Elastomer Scaffolds for Mechanical Stimulation Culture2008

    • Author(s)
      Taisuke Masuda
    • Organizer
      8th World Biomaterials Congress
    • Place of Presentation
      Amsterdamオランダ
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Fabrication of PDMS scaffold with controlled configuration2007

    • Author(s)
      T. Masuda, et al.
    • Organizer
      2007 International Symosium on Micro-Nano Mechatronics and Human Science
    • Place of Presentation
      Nagoya
    • Year and Date
      2007-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 勾配量メカニカルストレス培養システムの開発2007

    • Author(s)
      益田泰輔, ほか
    • Organizer
      第46回日本生体医工学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2007-04-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 勾配量メカニカルストレス培養システムの開発2007

    • Author(s)
      益田泰輔
    • Organizer
      第46回日本生体医工学会大会
    • Place of Presentation
      宮城県・仙台市
    • Year and Date
      2007-04-26
    • Related Report
      2007 Annual Research Report
  • [Book] Interface Oral Health Science 2007, Eds. M. Watanabe and O. Okuno2007

    • Author(s)
      T. Masuda, et al. (分担執筆)
    • Publisher
      Springer
    • Related Report
      2008 Final Research Report
  • [Book] Interface Oral Health Science 2007, Eds. M. Watanabe and O. Okuno2007

    • Author(s)
      Taisuke Masuda(分担執筆)
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www-kiso.dent.tohoku.ac.jp/cfe/index.html

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www-kiso.dent.tohoku.ac.jp/cfe/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www-kiso.dent.tohoku.ac.jp/cfe/index.html

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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