| Project/Area Number |
19700458
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Hiroshima International University |
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Principal Investigator |
OZAWA Junya Hiroshima International University, 保健医療学部・理学療法学科, 講師 (00435059)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥3,710,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 線維化 / TGF-ss1 / 脱神経 / 骨格筋 / collagen / TGF-β1 / type I collagen / type III collagen / transforming growth factor beta |
|---|
| Research Abstract |
In the soleus muscle, type I and III collagen deposition increased at intramusclular spaces following 7 and 14 days of denervation. Realtime PCR analysis revealed that type I collagen (COL1A1) mRNA expression did not change, and type III collagen (COL3A1) transiently decreased at 3 days after denervation. TGF-ss1 mRNA and protein expressions, on the other hand, elevated in a time-dependent manner, both TGF-ss1 mRNA and protein levels significantly increased at 14 days of denervation. TypeI and III collagen were increased with TGF-ss1 synchronously in denervated muscles in the early stage of fibrotic process.
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