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Plastic changes in functional connectivity by conditional TMS to the related regions on brain

Research Project

Project/Area Number 19700462
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionWaseda University (2008)
Research Institute, National Rehabilitation Center for Persons with Disabilities (2007)

Principal Investigator

SEKIGUCHI Hirofumi  Waseda University, 先端科学・健康医療融合研究機構, 講師 (20392201)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥2,750,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords経頭蓋磁気刺激 / 空間ワーキングメモリ / 前頭前野背外側部 / 頭頂連合野 / ヘブの法則 / 可塑性
Research Abstract

15名の被験者を対象に空間ワーキングメモリ課題の成績を比較・検討した結果、6ms(108.8±13.2%pre、mean±SD)、20ms(107.4±6.7%pre)の刺激間隔とParietalのみ(106.4±9.7%pre)の刺激において、刺激後のパフォーマンスが他の刺激間隔時よりも高値を示す傾向があった。しかしながら、統計的に有意な差は見られず、今回用いた刺激パラメータ(刺激強度、刺激頻度、刺激回数等)では、シナプス伝達効率の変調を示唆する明らかなパフォーマンスの変化を誘導することはできなかった。今後、上記の刺激間隔または刺激場所に特化して研究を進め、刺激強度や課題の難易度を再考するなどの必要が考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (6 results)

All 2007 2006 2005 2003 2000 Other

All Journal Article (6 results)

  • [Journal Article] 10/20,10/10, and 10/5 systems revisited : their validity as relative head-surface-based positioning systems2007

    • Author(s)
      Jurcak V., Tsuzuki D., and Dan I
    • Journal Title

      NeuroImage 34

      Pages: 1600-1611

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease2006

    • Author(s)
      Boggio PS., Ferrucci R., Rigonatti SPCovre P., Nitsche M., Pascual-Leone and Fregni F
    • Journal Title

      Journal of the Neurological Sciences 249

      Pages: 31-38

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effect of repetitive TMS and fluoxetine on cognitive funcation in patients with Parkinson's disease and concurrent depression2005

    • Author(s)
      Boggio PS., Fregni F., Bermpohl F., Mansur CG., Rosa M., Rumi DO., Barbosa ER. et al
    • Journal Title

      Movement Disorders 20

      Pages: 1178-1219

    • Related Report
      2008 Final Research Report
  • [Journal Article] A temporally asymmetric Hebbian rule governing plasticity in the human motor cortex2003

    • Author(s)
      Wolters A., Sandbrink F., Schlottmann Kunesch E., Stefan K., Cohen LG., BeneckR., and Classen J
    • Journal Title

      Journal of Neurophysiology 89

      Pages: 2339-2345

    • Related Report
      2008 Final Research Report
  • [Journal Article] Induction of plasticity in the human motor cortex by paired associative stimulation2000

    • Author(s)
      Stefan K., Kunesch E., Cohen LG., Benecke R., and Classen J
    • Journal Title

      Brain 123

      Pages: 572-584

    • Related Report
      2008 Final Research Report
  • [Journal Article] The organization of behavior

    • Author(s)
      Hebb DO
    • Journal Title

      A neuropsychological theory

    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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