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Paired associative stimulation of human spinal motoneuron based on a Hebbian mechanism

Research Project

Project/Area Number 19700464
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHiroshima University

Principal Investigator

TAKAHASHI Makoto  Hiroshima University, 大学院・保健学研究科, 助教 (50435690)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,560,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords経頭蓋磁気刺激 / 連合性ペア刺激 / Hebb則 / 可塑性 / リハビリテーション / 運動ニューロン / H反射 / 経皮的電気刺激
Research Abstract

本研究は脊髄運動ニューロンに対して,経頭蓋磁気刺激と末梢神経電気刺激の2つの刺激をHebb則に基づき一定の時間差,刺激強度で組み合わせた連合性ペア刺激(Pairedassociative stimulation)を行うことで,皮質脊髄路と脊髄運動ニューロン間のシナプス伝達効率を可塑的に変化させうることが明らかとなった.また,一側の運動野に対してPASを行うことで非刺激側である対側運動野の興奮性を変化させうることが明らかとなった.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (10 results) Book (4 results)

  • [Journal Article] 経頭蓋磁気刺激とニューロリハビリテーション.2008

    • Author(s)
      高橋真
    • Journal Title

      バイオメカニクス研究 12

      Pages: 184-190

    • Related Report
      2008 Final Research Report
  • [Journal Article] Changes in corticospinal excitability during observation of walking in humans.2008

    • Author(s)
      Makoto Takahashi, Tsuyoshi Nakajima, Kiyotaka Kamibayashi, Masami Akai, Kimitaka Nakazawa
    • Journal Title

      NeuroReport 19

      Pages: 727-731

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Load-related modulation of cutaneous reflexes in the tibialis anterior muscle during passive walking in humans.2008

    • Author(s)
      Tsuyoshi Nakajima, Kiyotaka Kamibayashi, Makoto Takahashi, Tomoyoshi Komiyama, Masami Akai, Kimitaka Nakazawa
    • Journal Title

      European Journal of Neuroscience 27

      Pages: 1566-1576

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phase-dependent modulation of cutaneous reflexes in tibialis anterior muscle during passive stepping.2008

    • Author(s)
      Tsuyoshi Nakajima, Kiyotaka Kamibayashi, Makoto Takahashi, Tomoyoshi Komiyama, Kimitaka Nakazawa
    • Journal Title

      Neurological Research 30

      Pages: 46-51

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Temporal modulations of agonist and antagonist muscle activities accompanying improved performance of ballistic movements.2008

    • Author(s)
      Nan Liang, Takamasa Yamashita, Zhen Ni, Makoto Takahashi, Tsuneji Murakami, Susumu Yahagi, Tatsuya Kasai
    • Journal Title

      Human Movement Science 27

      Pages: 12-28

    • NAID

      120000876558

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 経頭蓋磁気刺激とニューロリハビリテーション2008

    • Author(s)
      高橋真
    • Journal Title

      バイオメカニクス研究 12

      Pages: 184-190

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Changes in corticospinal excitability during observation of walking in humans2008

    • Author(s)
      Makoto Takahashi
    • Journal Title

      Neuro Report 19

      Pages: 727-731

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in corticospinal excitabiUty during observation of walking in humans2008

    • Author(s)
      Makoto Takahashi
    • Journal Title

      NeuroReport (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Control of heart rate variability by cardiac parasympathetic nerve activity during voluntary static exercise in humans with tetraplegia.2007

    • Author(s)
      Makoto Takahashi, Kanji Matsukawa, Tomoko Nakamoto, Hirotsugu Tsuchimochi, Akihiro Sakaguchi, Kotaro Kawaguchi, Kiyoshi Onari
    • Journal Title

      Journal of Applied Physiology 103

      Pages: 1669-1677

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of intermanual transfer induced by repetitive precision grip on input-output properties of untrained contralateral limb muscles.2007

    • Author(s)
      Nan Liang, Makoto Takahashi, Zhen Ni, Susumu Yahagi, Kozo Funase, Takashi Kato, Tatsuya Kasai
    • Journal Title

      Experimental Brain Research 182

      Pages: 459-467

    • NAID

      120000876559

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of motor imagery are dependent on motor strategies.2007

    • Author(s)
      Nan Liang, Zhen Ni, Makoto Takahashi, Tsuneji Murakami, Susumu Yahagi, Kozo Funase, Takashi Kato, Tatsuya Kasai
    • Journal Title

      Neuroreport 18

      Pages: 1241-1245

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of heart rate variability by cardiac parasympatlietic nerve activity during voluntary static exercise in humans with tetraplegia.2007

    • Author(s)
      Makoto Takahashi
    • Journal Title

      Journal of Applied Physiology 103

      Pages: 1669-1677

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Depression of the H-reflex amplitude in the tibialis anterior muscle during robot-assisted passive stepping in humans.2008

    • Author(s)
      Kiyotaka Kamibayashi, Tsuyoshi Nakajima, Makoto Takahashi, Masami Akai, Yoshiyuki Sankai, Kimitaka Nakazawa
    • Organizer
      Society for Neuroscience 38th Annual Meeting
    • Place of Presentation
      Washington, D. C., USA
    • Year and Date
      2008-11-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Differences in phase-dependent modulation of cutaneous reflexes between the ankle flexors and extensors during passive walking.2008

    • Author(s)
      Tsuyoshi Nakajima, Kiyotaka Kamibayashi, Makoto Takahashi, Tomoyoshi Komiyama, Kimitaka Nakazawa
    • Organizer
      Society for Neuroscience 38th Annual Meeting
    • Place of Presentation
      Washington, D. C.,USA
    • Year and Date
      2008-11-18
    • Related Report
      2008 Final Research Report
  • [Presentation] Spike-timing dependent plasticity in the human spinla motoneuonal pool.2008

    • Author(s)
      Hiroaki Obata, Makoto Takahashi, Daichi Nozaki, Kimitaka Nakazawa
    • Organizer
      Society for Neuroscience 38th Annual Meeting
    • Place of Presentation
      Washington, D. C.,USA
    • Year and Date
      2008-11-15
    • Related Report
      2008 Final Research Report
  • [Presentation] Motor facilitation during observation of walking.2008

    • Author(s)
      Makoto Takahashi, Kimitaka Kamibayashi, Tsuyoshi Nakajima, Kiyokazu Sekikawa, Tsutomu Inamizu,Masami Akai,Kimitaka Nakazawa
    • Organizer
      10th International Congress of the Asian Confederation for Physical Therapy
    • Place of Presentation
      10th International Congress of the Asian Confederation for Chiba
    • Year and Date
      2008-08-30
    • Related Report
      2008 Final Research Report
  • [Presentation] Motor facilitation during observation of walking2008

    • Author(s)
      Makoto Takahashi
    • Organizer
      10th International Congress of the Asian Confede ration for Physical Therapy
    • Place of Presentation
      千葉市
    • Year and Date
      2008-08-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cardiac parasympathetic nerve activity during voluntary static exercise in humans with tetraplegia.2007

    • Author(s)
      Makoto Takahashi, Kanji Matsukawa, Tomoko Nakamoto, Hirotsugu Tsuchimochi, Kiyokazu Sekikawa, Tsutomu Inamizu
    • Organizer
      The 3rd Asia-Pacific Conference on Exercise and Sports Science,
    • Place of Presentation
      Hiroshima
    • Year and Date
      2007-12-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Effect of load-related afferents on the corticospinal excitability in the lower limb muscles during robot assisted passive stepping in humans.2007

    • Author(s)
      Kiyotaka Kamibayashi, Tsuyoshi Nakajima, Makoto Takahashi, Masami Akai, Kimitaka Nakazawa
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Load-related modulation of cutaneous reflexes in the tibialis anterior muscle during passive stepping.2007

    • Author(s)
      Tsuyoshi Nakajima, Kiyotaka Kamibayashi, Makoto Takahashi, Tomoyoshi Komiyama, Masami Akai, Kimitaka Nakazawa
    • Organizer
      Society for Neuroscience 37th Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] 歩行観察中の皮質脊髄路の興奮性変化.2007

    • Author(s)
      高橋真,上林清孝,中島剛,赤居正美,中澤公孝
    • Organizer
      第42回 日本理学療法学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2007-05-25
    • Related Report
      2008 Final Research Report
  • [Presentation] 心拍変動周波数解析から心臓交感神経活動を推定できるか?2007

    • Author(s)
      高橋真,河江敏広,松川寛二,土持裕胤,中本智子,関川清一,稲水惇
    • Organizer
      第43回 日本理学療法学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2007-05-15
    • Related Report
      2008 Final Research Report
  • [Book] 運動学習,運動器リハビリテーションクルズス(岩谷力,他編集)2008

    • Author(s)
      高橋真,中澤公孝
    • Publisher
      南江堂
    • Related Report
      2008 Final Research Report
  • [Book] 運動器リハビリテーションクルズス2008

    • Author(s)
      高橋真
    • Publisher
      南江堂
    • Related Report
      2008 Annual Research Report
  • [Book] 加齢と循環調節,循環II運動時の調節と適応(斉藤満編著)2007

    • Author(s)
      松川寛二,中本智子,高橋真,小峰秀彦,土持裕胤
    • Publisher
      ナップ
    • Related Report
      2008 Final Research Report
  • [Book] Transworld Research Network2007

    • Author(s)
      Kanji Matsukawa, Hidehiko Komine, Tomoko Nakamoto, Hirotsugu Tsuchimochi, Makoto Takahashi
    • Publisher
      Patterned autonomic responses to real life challenges : Insights into central autonomic control, Central mechanisms of cardiovascular regulation (Editors Takao Kubo, Tomoyuki Kuwaki)
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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