| Budget Amount *help |
¥3,830,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥630,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
In this study, I examined the prolonged effects of single carnitine administration on the energy expenditure of fasted carnitine-deficient juvenile visceral steatosis (jvs^<-/->) mice. The study was able to evaluate the in vivo long-chain fatty acid (LCFA) oxidation activity of the mice under various conditions by intravenously injecting [1-^<14>C]-palmitic acid and measuring the breath or expiratory ^<14>C-CO_2. Leptin, which stimulates the AMP-activated protein kinase (AMPK), increased in the plasma after a single carnitine administration in jvs^<-/-> mice.
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