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Synchronization mechanisms for angiogenesis and mitochondrial biogenesis during muscle regeneration

Research Project

Project/Area Number 19700524
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionThe University of Tokyo

Principal Investigator

AGATSUMA Akira  The University of Tokyo, 大学院・総合文化研究科, リサーチ・レジデント (00347121)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,200,000 (Direct Cost: ¥2,200,000)
Keywords血管形成 / ミトコンドリア / 筋再生 / 骨格筋
Research Abstract

骨格筋の再生過程における血管新生およびミトコンドリアの発達の関連性について検討した。筋再生や血管新生、ミトコンドリアの発達に関わるほとんどの遺伝子の発現増強は、筋損傷3日日に見られる。しかしながら、再生筋繊維で損傷部位が修復されるのは14日日であり、このときにはまだ筋繊維周囲に毛細血管はほとんど存在せず、28日日に損傷前に近い毛細血管の分布が見られる。また、ミトコンドリアの酵素活性は筋損傷14日日にほぼ回復する。これらの結果から、筋再生とミトコンドリアの発達はほぼ同期的に行われていると考えられるが、筋繊維周囲への毛細血管の分布は遅れることが明らかになった。つまり、毛細血管の組織内分布よりも筋再生とミトコンドリアの発達が早く生じる可能性が示唆された。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (12 results)

All 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (6 results)

  • [Journal Article] Effect of hindlimb unweighting on expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, angiopoietin, and their receptors in mouse skeletal muscle2008

    • Author(s)
      Wagatsuma A.
    • Journal Title

      Physiol Res. 57(4)

      Pages: 613-620

    • Related Report
      2008 Final Research Report
  • [Journal Article] Effect of hindlimb unweighting on expression of hypoxia-inducible factor-1 alpha vascular endothelial growth factor, angiopoietin, and their receptors in mouse skeletal muscle2008

    • Author(s)
      Wagatsuma A
    • Journal Title

      Physiol Res 57

      Pages: 613-620

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipogenic potential can be activated during muscle regeneration2007

    • Author(s)
      Wagatsuma A.
    • Journal Title

      Mol Cell Biochem. 304(1-2)

      Pages: 25-33

    • Related Report
      2008 Final Research Report
  • [Journal Article] Endogenous expression of angiogenesis-related factors in response to muscle injury2007

    • Author(s)
      Wagatsuma A.
    • Journal Title

      Mol Cell Biochem. 298(1-2)

      Pages: 151-159

    • Related Report
      2008 Final Research Report
  • [Journal Article] Endogenous expression of angiogenesis-related factors in response to muscle injury2007

    • Author(s)
      Wagatsuma A
    • Journal Title

      Molecular and Cellular Biochemistry 298

      Pages: 151-159

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipogenic potential can be activated during muscle regeneration2007

    • Author(s)
      Wagatsuma A
    • Journal Title

      Molecular and Cellular Biochemistry 304

      Pages: 25-33

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Readthrough-inducing Ointment : The New Approach for the Treatment of Nonsense Mutation-mediated Disorders2008

    • Author(s)
      Shiozuka M, Kawamoto T, Sasaki H, Shimada K, Wagatsuma A, Nonomura Y, Matsuda R.
    • Organizer
      The American Society for Cell Biology 48^<th> Annual Meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2008 Final Research Report
  • [Presentation] 「リードスルー薬開発の現状」および「胸腺内抗原注射によって免疫寛容を誘導したmdxマウスへの筋芽細胞移植」「筋ジストロフィーおよびその関連疾患の分子病態解明、診断法確立と薬物治療の開発に関する研究」2008

    • Author(s)
      松田良一、塩塚政孝、我妻玲、平井康弘、高橋良和、野々村禎昭
    • Organizer
      平成20年度「砂田班」班会議
    • Place of Presentation
      東京、都市センターホール
    • Related Report
      2008 Final Research Report
  • [Presentation] ナンセンス変異を無効化する経皮的薬剤投与の評価2008

    • Author(s)
      塩塚政孝、川本忠文、我妻玲、嶋田健一、佐々木博之、野々村禎昭、松田良一
    • Organizer
      日本動物学会第79回大会
    • Place of Presentation
      福岡、福岡大学七隈キャンパス
    • Related Report
      2008 Final Research Report
  • [Presentation] Readthrough-inducing ointment : the new approach for the treatment of genetic disorders caused by nonsense mutations2008

    • Author(s)
      Shiozuka M, Kawamoto T, Sasaki H, Shimada K, Wagatsuma A, Nonomura Y, Matsuda R.
    • Organizer
      New Directions in Biology & Disease of skeletal muscle
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Final Research Report
  • [Presentation] Readthrough-induced ointment : the new approach for the treatment of genetic disorders caused bynonsence mutations2008

    • Author(s)
      Masataka S, Hiroyuki S, Kawamoto, Wagatsuma A, Nonomura Y, Matsuda
    • Organizer
      New directions in biology & disease of skeletal muscle
    • Place of Presentation
      New Orleans
    • Related Report
      2008 Annual Research Report
  • [Presentation] リードスルー薬物の経皮的デリバリー法の開発「筋ジストロフィーおよびその関連する疾患の病態生理の解明と治療薬物の開発に関する研究」2007

    • Author(s)
      松田良一、塩塚政孝、我妻玲、佐々木博之、野々村禎昭
    • Organizer
      平成19年度「清水班」班会議
    • Place of Presentation
      都市センターホール、東京
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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