Epidemiological study on the Fetal programming hypothesis - The effect of intrauterine environment on the growth and development of children

• Project/Area Number: 19700540
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Tohoku University
• Principal Investigator: KUROKAWA Naoyuki Tohoku University, 大学院医学系研究科, 助教 (30431505)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,590,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 胎内環境 / 出生体重 / コホート研究

Research Abstract

胎内環境が児の体格、特に体重はどのように変化するのかを明らかにすることを目的とした。463組の母子から得られたデータを基に解析を行った。出生体重と妊娠中の喫煙や飲酒との間に関連性は認められなかったが、臍帯血中PCB濃度との間に負の相関関係が観察された。また、42ヶ月時の体重と臍帯血中PCB濃度に正の相関関係が認められた。従って、胎児期におけるPCBばく露が出生時体重に影響を与え、その後の児の発育に関係することが示唆された。

Research Products

• [Journal Article] Trends of body mass index distribution in schoolchildren in Sendai, Japan, 1989-2003 (2009)
  • Author(s): Naoyuki Kurokawa, Kunihiko Nakai, Keita Suzuki, (他7名)
  • Journal Title: Obesity Research & Clinical Practice 3 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Trends of body mass index distribution in schoolchildren in Sendai, Japan. 1989-2003 (2009)
  • Author(s): N Kurokawa, et.al.
  • Journal Title: Obesity research & clinical practice 3 Pages: 21-27
  • Peer Reviewed
• [Journal Article] Trends in growth status among schoolchildren in Sendai, Japan, 1994-2003: leveling-off of mean body height and weight (2008)
  • Author(s): Naoyuki Kurokawa, Kunihiko Nakai, Keita Suzuki, (他5名)
  • Journal Title: Tohoku Journal of Experimental Medicine 216 Pages: 371-375
  • NAID: 10025104467
  • Peer Reviewed
• [Journal Article] Relationship between child birth weight and concentration of a biphenyls (PCBs) of the mother in Japan. -Tohoku Study of Child Development (TSCD)- (2008)
  • Author(s): Naoyuki Kurokawa, Kunihiko Nakai, Keita Suzuki ,(他8名)
  • Journal Title: Organohalogen Compounds 70 Pages: 2256-2259
  • Peer Reviewed
• [Journal Article] Relationship between child birth weight and concentration of polychlorinated biphenyls(PCBs)of the mother in Japan. -Tohoku Study of Child Development(TSCD)- (2008)
  • Author(s): N Kurokawa, et.al.
  • Journal Title: Organohalogen Compounds 70 Pages: 2256-2259
• [Journal Article] Trends in growth status among schoolchildren in Sendai, Japan, 1994-2003 : leveling-off of mean body height and weight (2008)
  • Author(s): N Kurokawa, et.al.
  • Journal Title: Tohoku Journal of Experimental Medicine 216 Pages: 371-375
  • NAID: 10025104467
  • Peer Reviewed
• [Presentation] 児童・生徒の肥満判定指標に関する問題点について (2008)
  • Author(s): 黒川修行,佐藤洋
  • Organizer: 第55回日本学校保健学会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-15
• [Presentation] 児童・生徒の肥満判定指標の関する問題点について (2008)
  • Author(s): 黒川修行、佐藤洋
  • Organizer: 第55回日本学校保健学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-11-15
• [Presentation] Relationship between child birth weight and concentration of a biphenyls (PCBs) of the mother in Japan. -Tohoku Study of Child Development (TSCD)- (2008)
  • Author(s): Naoyuki Kurokawa, Kunihiko Nakai, Keita Suzuki, (他8名)
  • Organizer: 28th International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: Birmingham, United Kingdom
  • Year and Date: 2008-08-18
• [Presentation] Relationship between child birth weight and concentration of polychlorinated biphenyls(PCBs)of the mother in Japan. -Tohoku Study of Child Develonment(TSCD)- (2008)
  • Author(s): N Kurokawa, et.al.
  • Organizer: 28th International Symposium on Halogenated Persistent Organic Pollutants
  • Place of Presentation: イギリス、バーミンガム
  • Year and Date: 2008-08-18
• [Presentation] 誕生月別にみた児童・生徒の身長・体重について (2007)
  • Author(s): 黒川修行,佐藤洋
  • Organizer: 第54回日本学校保健学会
  • Place of Presentation: 市川
  • Year and Date: 2007-09-15
• [Presentation] 誕生月別にみた児童・生徒の身長・体重について (2007)
  • Author(s): 黒川修行、佐藤 洋
  • Organizer: 第54回日本学校保健学会
  • Place of Presentation: 千葉県市川市
  • Year and Date: 2007-09-15
• [Presentation] Secular trends of height and weight of schoolchildren from 1934 to 2003 in Sendai, Japan. (2007)
  • Author(s): N Kurokawa, et. al.
  • Organizer: 11th International Congress of Auxology
  • Place of Presentation: 東京
  • Year and Date: 2007-09-11
• [Presentation] Secular trends in height and weight of schoolchildren from 1934 to 2003 in Sendai, Japan (2007)
  • Author(s): Naoyuki Kurokawa, Kouta Satoh, Kunihiko Nakai, (他6名)
  • Organizer: 11th International Congress of Auxology
  • Place of Presentation: Tokyo, Japan