Preventive effect of sesaminol on life style-related disease

• Project/Area Number: 19700590
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: University of Miyazaki
• Principal Investigator: NISHIZONO Shoko University of Miyazaki, 産学連携センター, 准教授 (40336970)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥5,280,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥780,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: ゴマリグナン / セサミノール配糖体 / 脂質代謝 / トコフェロール / セサミノール / コレステロール合成 / ステロイド排泄 / セサミノールグルコシド / 排泄率 / 血清コレステロール

Research Abstract

Sesaminol is a lignan with beneficial physiological activities derived from sesame. Effects of sesaminol triglycoside on lipid metabolism were investigated in rats. Sessaminol triglycoside was extracted from defatted sesame seed. Sesaminol triglycoside did not affect on serum and liver lipid levels, while sesamin decreased serum triglyceride level. d-Tocopherol contents in the liver were higher in sesaminol and sesamin groups compared to control group. These results suggest that sesaminol triglycoside exerts antioxidative activity as sesamin.

Research Products

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