| Project/Area Number |
19700596
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyushu Sangyo University |
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Principal Investigator |
TAKASUGI Mikako Kyushu Sangyo University, 工学部, 講師 (60305802)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,520,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | アレルギー・ぜんそく / 食品 / ロイコトリエン / アレルギー / マスト細胞 / ケミカルメディェーター / 大豆イソフラボン / ケミカルメディエーター |
|---|
| Research Abstract |
We developed the method to analyze regulatory factors of leukotriene release in a mouse mast cell line. The method was applied to investigate effect of soy isoflavones on leukotriene release from mast cells. It was elucidated that daizein and genistein, soy isoflavone agrycones and equol, a metabolite of soy isoflavone, supressed leukotrine B4 in dose-dependent manner. Equol also suppressed Ca^<2+> influx into mast cells, although genistein exerted no effect.
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