Mechanism for prevention of spontaneous stroke by epigallocatechin gallate in rats

• Project/Area Number: 19700604
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kinki University
• Principal Investigator: TABUCHI Masaki Kinki University, 医学部, 助教 (20340771)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
• Keywords: 循環器・高血圧 / 食品 / 緑茶カテキン / 脳卒中 / 酸化ストレス / アディポネクチン / 耐糖能

Research Abstract

緑茶の摂取が脳卒中発症を予防する機序を明らかにするために、悪性脳卒中易発症性高血圧自然発症ラットM-SHRSPに緑茶の主要成分エピガロカテキンガレート(EGCG)を長期間摂取させた.EGCGの摂取により、収縮期血圧の上昇抑制、アンジオテンシンIIの生成抑制、酸化ストレスの生成抑制、および耐糖能異常の改善が観察された.EGCGはこれらの機序を介して脳卒中発症を予防していることが明らかとなった.

Research Products

• [Journal Article] Hypersensitivity caused by suppression of descending inhibitory pathways following lumbar intrathecal injection of lidocaine in rats、Acta Med (2008)
  • Author(s): 田渕正樹(他4名、3番目)
  • Journal Title: Kinki Univ 33(1-2) Pages: 47-54
  • Peer Reviewed
• [Journal Article] Acetylsa licylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats (2008)
  • Author(s): 田渕正樹(他4名、3番目)
  • Journal Title: Life Sci 82(13-14) Pages: 806-815
  • Peer Reviewed
• [Journal Article] Hypersensitivity caused by suppression of descending inhibitory pathways following lumbar intrathecal injecti on of lidocaine in rats (2008)
  • Author(s): Fuyuta M, et.al.
  • Journal Title: Acta Med. Kinki Univ 33(1-2) Pages: 47-54
  • Peer Reviewed
• [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Leptcp/NDmcr rats (2007)
  • Author(s): 田渕正樹(他7名、2番目)
  • Journal Title: Clin. Exp. Pharmacol. Physiol 34(s1) Pages: 31-32
  • Peer Reviewed
• [Journal Article] 高血圧・肥満自然発症ラット(SHR.CgLeprcp/NDmcr)の循環パラメータに対するニコランジルの影響-テレメトリー装置を用いた検討- (2007)
  • Author(s): 田渕正樹(他8名、3番目)
  • Journal Title: Therapeutic Research 28(3) Pages: 413-418
  • Peer Reviewed
• [Journal Article] Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded stroke-prone rats (2007)
  • Author(s): 田渕正樹(他5名、3番目)
  • Journal Title: J. Hypertens 25(4) Pages: 861-870
  • Peer Reviewed
• [Journal Article] Preventive effects of green tea catechins on spontaneous stroke in rats (2007)
  • Author(s): 田渕正樹(他5名、5番目)
  • Journal Title: Med. Sci. Monit 13(2) Pages: 40-45
  • Peer Reviewed
• [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Lept^<cp>/NDmcr rats. (2007)
  • Author(s): Tei A., et. al.
  • Journal Title: Clin. Exp. Pharmmacol. Physiol. 34
  • Peer Reviewed
• [Journal Article] Involvement of thromboxane A_2 receptor in the cerebrovascular damage of salt-loaded stroke-prone rats. (2007)
  • Author(s): Ishizuka T., et. al.
  • Journal Title: J. Hypertens. 25 Pages: 861-870
  • Peer Reviewed
• [Journal Article] Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats.
  • Author(s): Ishizuka T., et. al.
  • Journal Title: Life Sci. (in press.)
  • Peer Reviewed
• [Presentation] 悪性脳卒中易発症性高血圧自然発症ラットにおける血中アディポネクチン濃度変化の検討 (2008)
  • Author(s): 田渕正樹
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分
  • Year and Date: 2008-10-18
• [Presentation] 悪性脳卒中易発症性高血圧自然発症ラットにおける血中アディポネクチン濃度変化の検討 (2008)
  • Author(s): 田渕正樹, 他
  • Organizer: 第29回日本肥満学会
  • Place of Presentation: 大分市
  • Year and Date: 2008-10-18
• [Presentation] 長期自発的運動のラット脳卒中発症予防効果 (2008)
  • Author(s): 田渕正樹
  • Organizer: 第16回日本運動生理学会大会
  • Place of Presentation: 奈良
  • Year and Date: 2008-08-02
• [Presentation] Protective effects of epig allocatechin gallate on spontaneous stroke in malignant stroke-prones pontaneously hypertensive rats (2008)
  • Author(s): 田渕正樹
  • Organizer: 第13回国際SHR シンポジウム、
  • Place of Presentation: プラハ
  • Year and Date: 2008-06-21
• [Presentation] Protective effects of epigallocatechin gallate on spon-taneous stroke in malignant stroke-prone spontaneously hypertensive rats (2008)
  • Author(s): Tabuchi M, et.al.
  • Organizer: 13th International SHR Symposium
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 2008-06-21
• [Presentation] Disturbance of circadian thythm in heart rate and blood pressure with a rapid rise of serm NOx at stroke-onset in malignant SHRSP (M-SHRSP) (2008)
  • Author(s): Ikeda M, et.al.
  • Organizer: 13th International SHR Symposium
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 2008-06-21
• [Presentation] Long-term voluntary exercise decreased the incidence of apoplexy and elomgated the lifespan through activati on of eNOS and inhibition of inflammatory signaling pathway in stroke-prone SHR (2008)
  • Author(s): Higashino H, et.al.
  • Organizer: 13th International SHR Symposium
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 2008-06-21
• [Presentation] エピガロカテキンガレートの脳卒中発症遅延効果 (2007)
  • Author(s): 大島佳奈 他
  • Organizer: 第43回高血圧関連疾患モデル学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2007-09-08
• [Presentation] 緑茶成分エピガロカテキンガレートのラット脳卒中発症遅延効果 (2007)
  • Author(s): 田渕正樹
  • Organizer: 第55回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
  • Year and Date: 2007-05-24
• [Presentation] エピガロカテキンガレートの脳卒中発症抑制効果 (2007)
  • Author(s): 田渕正樹
  • Organizer: 第61回日本栄養・食糧学会大会
  • Place of Presentation: 京都
  • Year and Date: 2007-05-20
• [Presentation] エピガロカテキンガレートの脳卒中発症抑制効果 (2007)
  • Author(s): 田渕正樹 他
  • Organizer: 第61回日本栄養・食糧学会大会
  • Place of Presentation: 京都市
  • Year and Date: 2007-05-20