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Mechanism for prevention of spontaneous stroke by epigallocatechin gallate in rats

Research Project

Project/Area Number 19700604
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionKinki University

Principal Investigator

TABUCHI Masaki  Kinki University, 医学部, 助教 (20340771)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,620,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords循環器・高血圧 / 食品 / 緑茶カテキン / 脳卒中 / 酸化ストレス / アディポネクチン / 耐糖能
Research Abstract

緑茶の摂取が脳卒中発症を予防する機序を明らかにするために、悪性脳卒中易発症性高血圧自然発症ラットM-SHRSPに緑茶の主要成分エピガロカテキンガレート(EGCG)を長期間摂取させた.EGCGの摂取により、収縮期血圧の上昇抑制、アンジオテンシンIIの生成抑制、酸化ストレスの生成抑制、および耐糖能異常の改善が観察された.EGCGはこれらの機序を介して脳卒中発症を予防していることが明らかとなった.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (11 results)

  • [Journal Article] Hypersensitivity caused by suppression of descending inhibitory pathways following lumbar intrathecal injection of lidocaine in rats、Acta Med2008

    • Author(s)
      田渕正樹(他4名、3番目)
    • Journal Title

      Kinki Univ 33(1-2)

      Pages: 47-54

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acetylsa licylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats2008

    • Author(s)
      田渕正樹(他4名、3番目)
    • Journal Title

      Life Sci 82(13-14)

      Pages: 806-815

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypersensitivity caused by suppression of descending inhibitory pathways following lumbar intrathecal injecti on of lidocaine in rats2008

    • Author(s)
      Fuyuta M, et.al.
    • Journal Title

      Acta Med. Kinki Univ 33(1-2)

      Pages: 47-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Leptcp/NDmcr rats2007

    • Author(s)
      田渕正樹(他7名、2番目)
    • Journal Title

      Clin. Exp. Pharmacol. Physiol 34(s1)

      Pages: 31-32

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高血圧・肥満自然発症ラット(SHR.CgLeprcp/NDmcr)の循環パラメータに対するニコランジルの影響-テレメトリー装置を用いた検討-2007

    • Author(s)
      田渕正樹(他8名、3番目)
    • Journal Title

      Therapeutic Research 28(3)

      Pages: 413-418

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of thromboxane A2 receptor in the cerebrovascular damage of salt-loaded stroke-prone rats2007

    • Author(s)
      田渕正樹(他5名、3番目)
    • Journal Title

      J. Hypertens 25(4)

      Pages: 861-870

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Preventive effects of green tea catechins on spontaneous stroke in rats2007

    • Author(s)
      田渕正樹(他5名、5番目)
    • Journal Title

      Med. Sci. Monit 13(2)

      Pages: 40-45

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nicorandil may change the sympathetic nerve activity of SHR.Cg-Lept^<cp>/NDmcr rats.2007

    • Author(s)
      Tei A., et. al.
    • Journal Title

      Clin. Exp. Pharmmacol. Physiol. 34

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of thromboxane A_2 receptor in the cerebrovascular damage of salt-loaded stroke-prone rats.2007

    • Author(s)
      Ishizuka T., et. al.
    • Journal Title

      J. Hypertens. 25

      Pages: 861-870

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats.

    • Author(s)
      Ishizuka T., et. al.
    • Journal Title

      Life Sci. (in press.)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 悪性脳卒中易発症性高血圧自然発症ラットにおける血中アディポネクチン濃度変化の検討2008

    • Author(s)
      田渕正樹
    • Organizer
      第29回日本肥満学会
    • Place of Presentation
      大分
    • Year and Date
      2008-10-18
    • Related Report
      2008 Final Research Report
  • [Presentation] 悪性脳卒中易発症性高血圧自然発症ラットにおける血中アディポネクチン濃度変化の検討2008

    • Author(s)
      田渕正樹, 他
    • Organizer
      第29回日本肥満学会
    • Place of Presentation
      大分市
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 長期自発的運動のラット脳卒中発症予防効果2008

    • Author(s)
      田渕正樹
    • Organizer
      第16回日本運動生理学会大会
    • Place of Presentation
      奈良
    • Year and Date
      2008-08-02
    • Related Report
      2008 Final Research Report
  • [Presentation] Protective effects of epig allocatechin gallate on spontaneous stroke in malignant stroke-prones pontaneously hypertensive rats2008

    • Author(s)
      田渕正樹
    • Organizer
      第13回国際SHR シンポジウム、
    • Place of Presentation
      プラハ
    • Year and Date
      2008-06-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Protective effects of epigallocatechin gallate on spon-taneous stroke in malignant stroke-prone spontaneously hypertensive rats2008

    • Author(s)
      Tabuchi M, et.al.
    • Organizer
      13th International SHR Symposium
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Disturbance of circadian thythm in heart rate and blood pressure with a rapid rise of serm NOx at stroke-onset in malignant SHRSP (M-SHRSP)2008

    • Author(s)
      Ikeda M, et.al.
    • Organizer
      13th International SHR Symposium
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Long-term voluntary exercise decreased the incidence of apoplexy and elomgated the lifespan through activati on of eNOS and inhibition of inflammatory signaling pathway in stroke-prone SHR2008

    • Author(s)
      Higashino H, et.al.
    • Organizer
      13th International SHR Symposium
    • Place of Presentation
      Prague (Czech Republic)
    • Year and Date
      2008-06-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] エピガロカテキンガレートの脳卒中発症遅延効果2007

    • Author(s)
      大島佳奈 他
    • Organizer
      第43回高血圧関連疾患モデル学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-09-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 緑茶成分エピガロカテキンガレートのラット脳卒中発症遅延効果2007

    • Author(s)
      田渕正樹
    • Organizer
      第55回日本生化学会近畿支部例会
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-24
    • Related Report
      2008 Final Research Report
  • [Presentation] エピガロカテキンガレートの脳卒中発症抑制効果2007

    • Author(s)
      田渕正樹
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都
    • Year and Date
      2007-05-20
    • Related Report
      2008 Final Research Report
  • [Presentation] エピガロカテキンガレートの脳卒中発症抑制効果2007

    • Author(s)
      田渕正樹 他
    • Organizer
      第61回日本栄養・食糧学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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