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Cellular senescence mechanisms and cellular antioxidant systems by lipid hydroperoxides

Research Project

Project/Area Number 19700605
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionMukogawa Women's University

Principal Investigator

YAMANAKA Yukako  Mukogawa Women's University, 生活環境学部, 助手 (80434934)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,450,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords食と栄養 / 細胞老化 / 脂質過酸化物 / チューブリン / 微小管 / 抗酸化酵素 / 抗酸化 / 細胞膜
Research Abstract

The aged society has come in the world including Japan. Then senile dementia lies as the problem to be conquest. The purpose of this investigation is to make clarify the aging mechanism of living cells and the results obtained would give the solution against a senile dementia. The effect of lipid hydroperoxides on PC12 cells, which is a model of nerve cells, was examined. Lipid hydroperoxides injured cell membrane and the cell functions were lost. Especially it was shown that lipid hydroperoxides damaged to the function of microtubules. Moreover, it was found that lipid hydroperoxides raised some enzyme activities of antioxidation system.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (11 results)

All 2010 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] NGF-induced neurite outgrowth of PC12 cells in the presence of phosphatidylcholine hydroperoxide: Implication for ageing2008

    • Author(s)
      Yukako Yamanaka, Shumi Yoshida, Hiroshi Doi
    • Journal Title

      Mechanisms of Aging and Development 129

      Pages: 215-222

    • Related Report
      2009 Final Research Report
  • [Journal Article] NGF-induced neurite outgrowth of PC12 cells in the presence of phosphatidylcholine hydroperoxides: Implication for ageing2008

    • Author(s)
      Yukako Yamanaka, Shumi Yoshida, Hiroshi Doi
    • Journal Title

      Mechanisms of Ageing and Development 129

      Pages: 215-222

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] リン脂質過酸化物により劣化した分化PC12細胞への抗酸化剤の効果2010

    • Author(s)
      山中裕佳子
    • Organizer
      2010年度日本農芸化学会大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] リン脂質過酸化物により劣化した分化PC12細胞への抗酸化剤の効果2010

    • Author(s)
      山中裕佳子
    • Organizer
      日本農芸化学会 2010年度大会
    • Place of Presentation
      東京大学
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 分化PC12細胞の抗酸化系へのリン脂質過酸化物の影響と抗酸化剤の効果2009

    • Author(s)
      山中裕佳子
    • Organizer
      2009年度日本農芸化学会大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 分化PC12細胞の抗酸化系へのリン脂質過酸化物の影響と抗酸化剤の効果2009

    • Author(s)
      山中裕佳子
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2009-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] リン脂質過酸化物存在下で培養された分化PC12細胞の抗酸化系への影響2008

    • Author(s)
      山中裕佳子
    • Organizer
      日本食品科学工学会第55回大会
    • Place of Presentation
      京都大学
    • Year and Date
      2008-09-07
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 脂質過酸化物添加によるPC12細胞の抗酸化系への影響2007

    • Author(s)
      山中裕佳子
    • Organizer
      日本栄養・食糧学会中・四国・近畿支部合同大会2007年大会
    • Place of Presentation
      広島大学
    • Year and Date
      2007-11-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 脂質過酸化物添加によるPC12細胞の抗酸化系への影響2007

    • Author(s)
      山中 裕佳子
    • Organizer
      平成19年 日本栄養・食糧学会中四国・近畿支部合同大会
    • Place of Presentation
      広島大学大学院生物圏科学研究科
    • Year and Date
      2007-11-18
    • Related Report
      2007 Annual Research Report
  • [Presentation] 脂質過酸化物添加培地で生育したPC12細胞への抗酸化剤の影響2007

    • Author(s)
      山中裕佳子
    • Organizer
      日本生物高分子学会2007年大会
    • Place of Presentation
      海峡メッセ下関国際貿易ビル
    • Year and Date
      2007-10-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 脂質過酸化物添加培地で生育したPC12細胞への抗酸化剤への影響2007

    • Author(s)
      山中 裕佳子
    • Organizer
      日本生物高分子学会2007年度大会
    • Place of Presentation
      海峡メッセ下関国際貿易ビル8階
    • Year and Date
      2007-10-19
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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