• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Safety and excretion mechanism of visible luminescent silicon nanopaticles in cell and animal

Research Project

Project/Area Number 19710098
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nanomaterials/Nanobioscience
Research InstitutionNational Institute for Materials Science

Principal Investigator

SATO Keisuke  National Institute for Materials Science, 量子ビームセンター・NIMSポスドク, 研究員 (70366384)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥1,380,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥600,000 (Direct Cost: ¥600,000)
Keywordsナノ粒子 / 半導体 / シリコンナノ粒子 / 可視発光 / バイオ / 細胞 / イメージング / 表面修飾 / 毒性
Research Abstract

シリコンナノ粒子表面にOH基を修飾することで、分散性の高い溶液を生成した。この分散溶液に光を照射することで、粒子サイズに依存した青色から赤色までの高輝度の可視発光を得た。また、シリコンナノ粒子は、細胞内に高濃度貪食させても生存率の低下がみられず、細胞レベルでの安全性を確認した。さらに、生体内にシリコンナノ粒子を投与することで、血流の状況を可視化計測することができた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (35 results)

All 2009 2008 2007 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (12 results) Book (6 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Doping and characterization of boron atoms in nanocrystalline silicon particles2009

    • Author(s)
      K. Sato, N. Fukata and K. Hirakuri
    • Journal Title

      Applied Physics Letters 94

      Pages: 161902-161902

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Facile preparation of red luminescent silicon nanocrystals via controlled chemical etching2009

    • Author(s)
      K. Sato, H. Tsuji, N. Fukata, K. Hirakuri and Y. Yamauchi
    • Journal Title

      Chemistry Letters 38

      Pages: 558-559

    • NAID

      10025122801

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] シリコンナノ粒子系エレクトロルミネッセンス素子の不純物ドーピングによるキャリア注入効率向上2009

    • Author(s)
      佐藤慶介、新野一樹、深田直樹、平栗健二
    • Journal Title

      照明学会誌 93

      Pages: 307-311

    • NAID

      110007327038

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxicity effect of cancer cell labeled with visible luminescent nanocrystalline silicon particles and visualization observation in vivo2009

    • Author(s)
      K. Sato, M. Hiruoka, K. Fujioka, N. Fukata, K. Hirakuri and K. Yamamoto
    • Journal Title

      Materials Research Society Symposium Proceedings 1145

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Luminescent passive-oxidated silicon quantum dots as biological staining labels and their cytotoxicity effects at high concentration2008

    • Author(s)
      K. Fujioka, M. Hiruoka, K. Sato, N. Manabe, R. Miyasaka, S. Hanada, A. Hoshino, R. D. Tilley, Y. Manome, K. Hirakuri and K. Yamamoto
    • Journal Title

      Nanotechnology 19

      Pages: 415102-415102

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of electroluminescent properties in ethanol dispersible nanocrystalline silicon particles2008

    • Author(s)
      K. Sato, N. Kishimoto and K. Hirakuri
    • Journal Title

      Journal of Nanoscience and Nanotechnology 8

      Pages: 374-378

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White luminescence from silica glass containing red/green/blue luminescent nanocrystalline silicon particles2007

    • Author(s)
      K. Sato, N. Kishimoto and K. Hirakuri
    • Journal Title

      Journal of Applied Physics 102

      Pages: 104305-104305

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between surface composition and luminescence of nanocrystalline silicon particles dispersed in pure water2007

    • Author(s)
      M. Hiruoka, K. Sato and K. Hirakuri
    • Journal Title

      Journal of Applied Physics 102

      Pages: 24308-24308

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of luminescence degradation in pure water of nanocrystalline silicon particles covered by a hydrogenated amorphous carbon layer2007

    • Author(s)
      K. Sato, N. Kishimoto, T. Oku and K. Hirakuri
    • Journal Title

      Journal of Applied Physics 102

      Pages: 14302-14302

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bioligical properties of nanocrystalline silicon particles for biomedical applications2007

    • Author(s)
      K. Sato, S. Yanagisawa, A. Funakubo, Y. Fukui, K. Hirakuri and T. Higami
    • Journal Title

      Materials Research Society Symposium Proceedings 958

      Pages: 263-268

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of luminescence degradation in pure water of nanocrystalline silicon particles covered by a hydrogenated a-C layer2007

    • Author(s)
      K. Sato, N. Kishimoto, T. Oku and K. Hirakuri
    • Journal Title

      Journal of Applied Physics 102

      Pages: 14302-14302

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlled chemical etching for silicon nanocrystals with wavelength-tunable photoluminescence

    • Author(s)
      K. Sato, H. Tsuji, K. Hirakuri, N. Fukata and Y. Yamauchi
    • Journal Title

      Chemical Communications (in press)

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] シリコンナノ粒子系エレクトロルミネッセンス素子の不純物ドーピングによるキャリア注入効率向上

    • Author(s)
      佐藤慶介、新野一樹、深田直樹、平栗健二
    • Journal Title

      照明学会誌論文 (印刷中)

    • NAID

      110007327038

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile synthesis of red luminescent silicon nanocrystals via controlled chemical etching

    • Author(s)
      K. Sato, H. Tsuji, N. Fukata, K. Hirakuri, Y. Yamauchi
    • Journal Title

      Chemistry Letters (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Doping and characterization of boron atoms in nanocrystaUine silicon Particles

    • Author(s)
      K. Sato, N. Fukata, K. Hirakuri
    • Journal Title

      Applied Physics Letters (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Silicon nanoparticles as fluorescent labeling of living cells2009

    • Author(s)
      K. Sato
    • Organizer
      MANA International Symposium 2009
    • Place of Presentation
      Ibaraki, Japan
    • Year and Date
      2009-02-26
    • Related Report
      2008 Final Research Report
  • [Presentation] Toxicity effect of cancer cell labeled with visible luminescent nanocrystalline silicon particles and visualization observation in vivo2008

    • Author(s)
      K. Sato, N. Fukata, M. Hiruoka, K. Hirakuri, K. Fujioka and K. Yamamoto
    • Organizer
      Materials Research Society 2008 Fall Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2008-12-01
    • Related Report
      2008 Final Research Report
  • [Presentation] Toxicity effect of cancer cell labeled with visible luminescent nanocrystalline silicon particles and visualization observation in vivo2008

    • Author(s)
      K Sato, N. Fukata, M. Hiruoka, K. Hirakuri, K. Fujioka, K. Yamamoto
    • Organizer
      Materials Research Society 2008 Fall Meeting
    • Place of Presentation
      米国、ボストン
    • Year and Date
      2008-12-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Annealing behavior on luminescent color from nanocrystalline silicon particles2007

    • Author(s)
      K. Sato and K. Hirakuri
    • Organizer
      The Sixth Pacific Rim International Conference on Advanced Materials and Processing
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2007-11-09
    • Related Report
      2008 Final Research Report
  • [Presentation] 新規機能性を付加したシリコンナノ粒子の各種デバイス応用(招待講演)2007

    • Author(s)
      佐藤慶介
    • Organizer
      明治大学先端半導体ワークショップ
    • Place of Presentation
      神奈川
    • Year and Date
      2007-10-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Luminescent state evaluation of nanocrystalline silicon particles studied by light-irradiated ESR method2007

    • Author(s)
      K. Sato and K. Hirakuri
    • Organizer
      11th International Conference on Defects-Recognition, Imaging and Physics in Semiconductors
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2007-09-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 可視発光機能性シリコンナノ粒子の細胞毒性試験および生体内動態観察2007

    • Author(s)
      佐藤慶介、昼岡正樹、平栗健二、藤岡宏樹、山本健二、樋上哲哉
    • Organizer
      第68回秋季応用物理学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2007-09-06
    • Related Report
      2008 Final Research Report
  • [Presentation] Stable luminescence in pure water from carbon passivated nanocrystalline silicon particles2007

    • Author(s)
      K. Sato, M. Hiruoka and K. Hirakuri
    • Organizer
      11th International Conference on the Formation of Semiconductor Interfaces
    • Place of Presentation
      Manaus, Brazil
    • Year and Date
      2007-08-21
    • Related Report
      2008 Final Research Report
  • [Presentation] Application of solution dispersible nanocrystalline silicon particles to various optical devices(招待講演)2007

    • Author(s)
      K. Sato, M. Hiruoka and K. Hirakuri
    • Organizer
      Fifteenth International Conference on Composites/Nano Engineering
    • Place of Presentation
      Haikou, China
    • Year and Date
      2007-07-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Application of solution dispersible nanocrystalline silicon particles to various optical devices2007

    • Author(s)
      K. Sato, M. Hiruoka and K. Hirakuri
    • Organizer
      Fifteenth International Conference on Composites/Nano Engineering
    • Place of Presentation
      Haikou, China
    • Year and Date
      2007-07-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] Effect of surface composition on luminescent property from nanocrystalline silicon particles immersed in pure water2007

    • Author(s)
      K. Sato, M. Hiruoka and K. Hirakuri
    • Organizer
      International Conference on Nano Science and Technology 2007
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2007-07-03
    • Related Report
      2008 Final Research Report
  • [Presentation] 可視発光機能性シリコンナノ粒子の生体安全性および生体内流動性試験2007

    • Author(s)
      佐藤慶介、昼岡正樹、平栗健二、舟久保昭夫、福井康裕、藤岡宏樹、山本健二、樋上哲哉
    • Organizer
      ナノ学会第5回大会
    • Place of Presentation
      茨城
    • Year and Date
      2007-05-22
    • Related Report
      2008 Final Research Report
  • [Book] 第3版現代界面コロイド化学の基礎2009

    • Author(s)
      佐藤慶介
    • Publisher
      丸善株式会社
    • Related Report
      2008 Final Research Report
  • [Book] 光アライアンス2009

    • Author(s)
      佐藤慶介、平栗健二
    • Publisher
      日本工業出版
    • Related Report
      2008 Final Research Report
  • [Book] 電子材料2008

    • Author(s)
      佐藤慶介
    • Publisher
      工業調査会
    • Related Report
      2008 Final Research Report
  • [Book] 量子ドットの生命科学領域への応用2007

    • Author(s)
      佐藤慶介
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Book] クリーンテクノロジー2007

    • Author(s)
      佐藤慶介
    • Publisher
      日本工業出版
    • Related Report
      2008 Final Research Report
  • [Book] 第3版現代界面コロイド化学の基礎

    • Author(s)
      佐藤慶介
    • Publisher
      丸善株式会社(印刷中)
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] ドライプロセス装置2009

    • Inventor(s)
      佐藤慶介、深田直樹
    • Industrial Property Rights Holder
      独立行政法人物質・材料研究機構
    • Filing Date
      2009-01-16
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] ドライプロセス装置2009

    • Inventor(s)
      佐藤慶介、深田直樹
    • Industrial Property Rights Holder
      岸輝雄
    • Industrial Property Number
      2009-007329
    • Filing Date
      2009-01-16
    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi