The effects of cognitive-behavioral therapy for depression : An fMRI study

• Project/Area Number: 19730431
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Clinical psychology
• Research Institution: The University of Tokyo
• Principal Investigator: UEDA Kazutaka The University of Tokyo, 先端科学技術研究センター, 特任助教 (10403594)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,870,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥570,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
• Keywords: うつ病 / 認知障害 / 認知行動療法 / 脳機能 / fMRI / Fmri / f MRI

Research Abstract

The findings of this study suggest that cognitive dysfunction for prediction of future reward in patients with major depressive disorder (MDD) is associated with abnormal prefrontal cortical and striatal activation. The brain activity in these regions in patients with MDD may be useful to predict the response to cognitive-behavioral therapy (CBT) and to evaluate the effect of CBT.

Research Products

• [Journal Article] Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity. (2010)
  • Author(s): Yoshimura S., Okamoto Y., Onoda K., Matsunaga M., Ueda K., Suzuki S., Yamawaki S.
  • Journal Title: Journal of Affective Disorders. 122(1-2) Pages: 76-85
  • Peer Reviewed
• [Journal Article] Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity (2010)
  • Author(s): Yoshimura, S.
  • Journal Title: Journal of Affective Disorders 122(1-2) Pages: 76-85
  • Peer Reviewed
• [Journal Article] Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala. (2009)
  • Author(s): Yoshimura S., Ueda K., Suzuki S., Onoda K., Okamoto Y., Yamawaki S.
  • Journal Title: Brain and Cognition. 69(1) Pages: 218-225
  • Peer Reviewed
• [Journal Article] Attenuated prefrontal activation during a verbal fluency task in remitted major depression. (2009)
  • Author(s): Okada G., Okamoto Y., Yamashita H., Ueda K., Takami H., Yamawaki S.
  • Journal Title: Psychiatry and Clinical Neurosciences. 63(3) Pages: 423-425
  • Peer Reviewed
• [Journal Article] Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala (2009)
  • Author(s): Yoshimura, S.
  • Journal Title: Brain and Cognition 69(1) Pages: 218-225
  • Peer Reviewed
• [Journal Article] Attenuated prefrontal activation during a verbal fluency task in remitted major depression (2009)
  • Author(s): Okada, G.
  • Journal Title: Psychiatry and Clinical Neurosciences 63(3) Pages: 423-425
  • Peer Reviewed
• [Journal Article] Anterior cingulate cortex during certain anticipation of negative picture modulate preparatory activation of occipital area. (2008)
  • Author(s): Onoda K., Okamoto Y., Toki S., Ueda K., Shishida K., Kinoshita A., Yoshimura S., Yamashita H., Yamawaki S.
  • Journal Title: Neuropsychologia. 46(1) Pages: 102-110
  • Peer Reviewed
• [Journal Article] ストレス脆弱性克服に挑む教育科学と脳科学-抑うつのストレス認知に関する心理・生物学的メカニズムの検討- (2007)
  • Author(s): 上田一貴, 前田健一, 兒玉憲一, 岡本祐子, 松下姫歌, 大塚泰正
  • Journal Title: 広島大学大学院心理臨床教育研究センター紀要 6 Pages: 138-145
  • NAID: 120000876715
• [Presentation] うつ病の脳機能画像研究の臨床実践への応用可能性うつ病理解における心理生理学的アプローチ (2009)
  • Author(s): 上田一貴
  • Organizer: 日本心理学会第73回大会
  • Place of Presentation: 京都
  • Year and Date: 2009-08-28
• [Presentation] うつ病の脳機能画像研究の臨床実践への応用可能性 (2009)
  • Author(s): 上田一貴
  • Organizer: 日本心理学会第73回大会
  • Place of Presentation: 京都
  • Year and Date: 2009-08-28
• [Presentation] 福祉と研究の専門化をめぐる対談-社会福祉への架橋について-心理生理学・脳科学から「人間」を観る (2008)
  • Author(s): 上田一貴
  • Organizer: 日本応用心理学会第75回大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-15
• [Presentation] 福祉と研究の専門化をめぐる対談-社会福祉への架橋について- (2008)
  • Author(s): 上田一貴
  • Organizer: 日本応用心理学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-15
• [Book] 心理生理学と脳科学(「医療心理学の新展開」鈴木伸一編) (2008)
  • Author(s): 上田一貴
  • Publisher: 北大路書房
• [Book] 医療心理学の新展開 (2008)
  • Author(s): 上田一貴
  • Total Pages: 213
  • Publisher: 北大路書房