Study of biological functions through formulation of the response theory of reaction network system

• Project/Area Number: 19740260
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biophysics/Chemical physics
• Research Institution: Hiroshima University
• Principal Investigator: AWAZU Akinori Hiroshima University, 大学院・理学研究科, 助教 (00448234)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,040,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
• Keywords: 触媒反応ネットワーク / 分子少数性 / 緩和 / 反応ネットワーク / 代謝系 / 化学反応ネットワーク / 分子の少数性 / エネルギー論 / 自己組織化臨界現象 / ガラス転移 / FFLCA / 化学反応 / ネットワーク

Research Abstract

We investigated the dynamical properties of catalytic reaction network systems inspired by the biochemical reaction networks in cells. We found the catalytic reaction systems involving not large enough number of molecules like cells generally realize the following phenomena. 1) The phase transition and self-organized criticality appear by the molecular number deficiency. 2) Slow relaxation to thermodynamic equilibrium state. We also proposed the origin of the phenotype fluctuation by these phenomena.

Research Products

• [Journal Article] Discreteness-Induced Slow Relaxation in Reversible Catalytic Reaction Networks (2010)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Journal Title: Phys.Rev.E 81
  • Peer Reviewed
• [Journal Article] Discreteness-Induced Slow Relaxation in Reversible Catalytic Reaction Networks (2010)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Journal Title: Physical Review E Volume: 81
  • Peer Reviewed
• [Journal Article] Discreteness-Induced Slow Relaxation in Reversible Catalytic Reaction Networks (2010)
  • Author(s): A. Awazu, K. Kaneko
  • Journal Title: Phys. Rev. E (in press)
  • Peer Reviewed
• [Journal Article] Ubiquitous "glassy" relaxation in catalytic reaction networks (2009)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Journal Title: Phys.Rev.E 80
  • NAID: 120001924004
  • Peer Reviewed
• [Journal Article] Self-organized criticality of a catalytic reaction network under flow (2009)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Journal Title: Phys.Rev.E 80
  • NAID: 120001924003
  • Peer Reviewed
• [Journal Article] Ubiquitous "glassy" relaxation in catalytic reaction networks (2009)
  • Author(s): A. Awazu, K. Kaneko
  • Journal Title: Phys. Rev. E 80
  • NAID: 120001924004
  • Peer Reviewed
• [Journal Article] Self-organized criticality of a catalytic reaction network under flow (2009)
  • Author(s): A. Awazu, K. Kaneko
  • Journal Title: Phys. Rev. E 80
  • NAID: 120001924003
  • Peer Reviewed
• [Journal Article] Self-organized criticality of a catalytic reaction network under flow (2009)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Journal Title: Physical Review E 80
  • NAID: 120001924003
  • Peer Reviewed
• [Journal Article] Ubiquitous "glassy" relaxation in catalytic reaction networks (2009)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Journal Title: Physical Review E 80
  • NAID: 120001924004
  • Peer Reviewed
• [Journal Article] Input-dependent wave propagations in asymmetric cellular automata : Possible behaviors of feed-forward loop in biological reaction network (2008)
  • Author(s): Akinori Awazu
  • Journal Title: Math.Biosci.Eng. 5 Pages: 419-427
  • Peer Reviewed
• [Journal Article] Input-dependent wave propagations in asymmetric cellular automata : Possible behaviors of feed-forward loop in biological reaction network (2008)
  • Author(s): Akinori Awazu
  • Journal Title: Mathematical Biosciences and Engineering 5 Pages: 419-427
  • Peer Reviewed
• [Journal Article] Discreteness-induced Transition in Catalytic Reaction Networks (2007)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Journal Title: Phys.Rev.E 76
  • Peer Reviewed
• [Journal Article] Discreteness-induced Transition in Catalytic Reaction Networks (2007)
  • Author(s): Akinori Awazu
  • Journal Title: Physical Review E 76 Pages: 41915-41915
  • Peer Reviewed
• [Journal Article] Network Structure Formations in Pulsating Particle Populations (2007)
  • Author(s): Akinori Awazu
  • Journal Title: Physical Review E 76
  • Peer Reviewed
• [Presentation] Glassy behaviors in catalytic reaction networks (2010)
  • Author(s): 粟津暁紀
  • Organizer: 基研研究会 非平衡系の物理
  • Place of Presentation: 京都大学
  • Year and Date: 2010-11-19
• [Presentation] 可逆触媒反応ネットワーク群が構成する'生態系'の環境変動に対する応答 (2010)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会秋期大会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2010-09-19
• [Presentation] Glassy dynamics in catalytic reaction networks (2010)
  • Author(s): Akinori Awazu
  • Organizer: DYNAMICS DAYS ASIA PACIFIC 6
  • Place of Presentation: University of New South Wales, Australia(招待講演)
  • Year and Date: 2010-07-13
• [Presentation] 可逆触媒反応ネットワーク系の構造と機能性:定常状態と緩和と効率 (2010)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2010-03-20
• [Presentation] Glassy behaviors in catalytic reaction networks (2010)
  • Author(s): 粟津暁紀
  • Organizer: 基研研究会非平衡系の物理-非平衡ゆらぎと集団挙動
  • Place of Presentation: 京都大学
• [Presentation] 可逆触媒反応ネットワーク群が構成する"生態系"の環境変動に対する応答 (2010)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会秋期大会
  • Place of Presentation: 大阪府立大学
• [Presentation] 粒子の離散性による触媒反応ネットワークの緩和時間の変化 (2010)
  • Author(s): 佐野真二, 粟津暁紀, 金子邦彦
  • Organizer: 日本物理学会秋期大会
• [Presentation] Evolution of ecological network of ideal metabolic networks under fluctuating environment (2010)
  • Author(s): 粟津暁紀
  • Organizer: 日本生物物理学会
  • Place of Presentation: 東北大学
• [Presentation] Glassy dynamics in catalytic reaction networks (2010)
  • Author(s): Akinori Awazu
  • Organizer: DYNAMICS DAYS ASIA PACIFIC 6
  • Place of Presentation: University of New South Wales, Australia
• [Presentation] 可逆触媒反応ネットワーク系の構造と機能性:定常状態と緩和と効率 (2010)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会年次大会
  • Place of Presentation: 岡山大学
• [Presentation] 分子内力学ネットワークと分子間反応ネットワークのフラストレーションと機能 (2009)
  • Author(s): 粟津暁紀
  • Organizer: 日本生物物理学会
  • Place of Presentation: アスティ徳島
  • Year and Date: 2009-10-31
• [Presentation] Discreteness-induced transition and self-organized criticality in catalytic reaction networks (2009)
  • Author(s): Akinori Awazu
  • Organizer: International symposium on Complex System Biology
  • Place of Presentation: 東京大学
  • Year and Date: 2009-09-30
• [Presentation] Molecular Discreteness Induced Slow Relaxation in Reversible Catalytic Reaction Networks (2009)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会
  • Place of Presentation: 東京都(立教大学)
  • Year and Date: 2009-03-29
• [Presentation] Self-organized criticality of a catalytic reaction network (2009)
  • Author(s): Akinori Awazu, Kunihiko Kaneko
  • Organizer: International Symposium on Complex system biology.
  • Place of Presentation: Tokyo Univ.
• [Presentation] Molecular Discreteness Induced Slow Relaxation in Reversible Catalytic Reaction Networks (2009)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会年会
  • Place of Presentation: 立教大学
• [Presentation] 触媒反応ネットワークの緩和過程における粒子の離散性効果 (2009)
  • Author(s): 佐野真二、粟津暁紀、金子邦彦
  • Organizer: 日本物理学会年会
  • Place of Presentation: 立教大学
• [Presentation] Control of energy flows in biochemical reaction system (2008)
  • Author(s): 粟津暁紀
  • Organizer: 日本生物物理学会
  • Place of Presentation: 福岡市(福岡国際会議場)
  • Year and Date: 2008-12-04
• [Presentation] Self-organized criticality in catalytic reaction network (2008)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会
  • Place of Presentation: 盛岡市(岩手大学)
  • Year and Date: 2008-09-23
• [Presentation] Glassy Behaviors in Catalytic Reaction Network II (2008)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会
  • Place of Presentation: 盛岡市(岩手大学)
  • Year and Date: 2008-09-20
• [Presentation] Glassy Behaviors in Catalytic Reaction Network II (2008)
  • Author(s): 粟津暁紀、金子邦彦
  • Organizer: 日本物理学会秋季大会
  • Place of Presentation: 岩手大学
• [Presentation] Self-organized criticality in catalytic reaction network (2008)
  • Author(s): 粟津暁紀、金子邦彦
  • Organizer: 日本物理学会秋季大会
  • Place of Presentation: 岩手大学
• [Presentation] Glassy Behaviors in Catalytic Reaction Network (2008)
  • Author(s): 粟津暁紀、金子邦彦
  • Organizer: 日本物理学会年会
  • Place of Presentation: 近畿大学
• [Presentation] Transition by Molecular Number Fluctuation in Reaction Network (2007)
  • Author(s): 粟津暁紀
  • Organizer: 日本生物物理学会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] 反応ネットワーク系の構造、ダイナミックス、分子の離散性効果の関係 (2007)
  • Author(s): 粟津暁紀
  • Organizer: 日本物理学会年会
  • Place of Presentation: 北海道大学