Selective Organic Synthesis with Polyorganometallic Reagents

• Project/Area Number: 19750031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Kyoto University
• Principal Investigator: KURAHASHI Takuya Kyoto University, 大学院・工学研究科, 助教 (50432365)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 有機金属化学 / 有機金属 / ホウ素 / 亜鉛 / 遷移金属 / 多置換亜鉛 / 多置換オレフィン

Research Abstract

現在の有機合成化学は有機金属化合物なくして成り立たない。炭素-金属結合の多様な反応性が有機合成に革新をもたらしているからである。同一炭素上に複数の金属を有する有機多金属反応剤は従来にない高度分子変換を可能にする事が期待できる。申請者はこれまでの知見を基にして、本研究では有機多金属反応剤の効率的な合成法の確立と、有機多金属反応剤を用いた高度分子変換反応の開発を目的として研究を行った。

Research Products

• [Journal Article] Nickel-Catalyzed [4+2] Cycloaddition of Enones with Alkynes (2009)
  • Author(s): Ichiro Koyama, Takuya Kurahashi, and Seijiro Matsubara
  • Journal Title: J. Am. Chem. Soc. 131巻 Pages: 1350-1351
  • Peer Reviewed
• [Journal Article] Nickel-Catalyzed Decarbonylative Addition of Phthalimides to Alkynes (2008)
  • Author(s): Yuichi Kajita, Takuya Kurahashi, and Seijiro Matsubara
  • Journal Title: J. Am. Chem. Soc. 130巻 Pages: 6058-6059
  • Peer Reviewed
• [Journal Article] Nickel-Catalyzed Decarbonylative Addition of Anhydrides to Alkynes (2008)
  • Author(s): Yuichi Kajita, Takuya Kurahashi, and Seijiro Matsubara
  • Journal Title: J. Am. Chem. Soc. 130巻 Pages: 17226-17227
  • Peer Reviewed
• [Journal Article] Nickel-Catalyzed Decarbonylative Addition of Phthalimides to Alkynes (2008)
  • Author(s): Yuichi Kajita, Takuya Kurahashi, and Seijiro Matsubara,
  • Journal Title: J. Am. Chem. Soc 130 Pages: 6058-6059
  • Peer Reviewed
• [Journal Article] Nickel-Catalyzed Decarbonylative Addition of Anhydrides to Alkynes (2008)
  • Author(s): Yuichi Kajita, Takuya Kurahashi, and Seijiro Matsubara,
  • Journal Title: J. Am. Chem. Soc 130 Pages: 17226-17227
  • Peer Reviewed
• [Journal Article] Nickel-Catalyzed [4+2] Cycloaddition of Enones with Alkyne (2008)
  • Author(s): Ichiro Koyama, Takuya Kurahashi, and Seijiro Matsubara,
  • Journal Title: J. Am. Chem. Soc. 131 Pages: 1350-1351
  • Peer Reviewed
• [Journal Article] 1, 1'-Linked cyclopropane derivatives: The helical conformation of quinquecyclopropanol (2007)
  • Author(s): Kurahashi, T.; Kozhushkov, S. I.; Schill, H.; Meindl, K.; Ruehl, S.; de Meijere, A
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 6545-6548
  • Peer Reviewed
• [Journal Article] Facile synthesis and palladium-catalyzed cross-coupling reactions of 2,3-bis (pinacolatoboryl)-l, 3-butadiene (2007)
  • Author(s): Shimizu, M.; Kurahashi, T.; Shimono, K.; Tanaka, K.; Nagao, I.; Kiyomoto, S.; Hiyama, T.
  • Journal Title: Chem. Asian. J 2 Pages: 1400-1408
  • Peer Reviewed
• [Presentation] Synthesis of Heterocyclic Compounds via Nickel-Catalyzed Addition of C-N and C-O Bond to Alkynes (2008)
  • Author(s): 倉橋拓也、松原誠二郎
  • Organizer: 第55回有機金属化学討論会
  • Place of Presentation: 大阪府立大学
  • Year and Date: 2008-09-29
• [Presentation] Synthesis of Isoquinolones via Nickel-Catalyzed Decarbonylative Carboamination of Alkynes with Phthalimides (2007)
  • Author(s): 梶田雄一、倉橋拓也、松原誠二郎
  • Organizer: 第54回有機金属化学討論会
  • Place of Presentation: 広島大学
  • Year and Date: 2007-10-27