Clarification of Mechanisms on DNA Damage by Electron-Transfer Reduction and Radical Species
| Project/Area Number |
19750034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OHKUBO Kei Osaka University, 大学院工学研究科, 特任研究員 (00379140)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 有機物理化学 / 電子移動化学 / 活性酸素種 / DNA損傷 / 神経伝達物質 / 金属イオン / ヒドロキシルラジカル / ニコチンアミドアデニンジヌクレオチド / 緑茶カテキン / 水素引童抜き反応 / ビタミンB12 / ラジカル / 光反応 / コバルト / 錯体 / DNA / 核酸塩基 / 損傷 |
|---|
| Research Abstract |
DNAの損傷は突然変異を引き起こし、細胞の死やがん化の原因となる。そのためこのDNA損傷の化学反応を制御する機構の解明は、次世代の医療の新手法開発にもつながる極めて重要な課題である。本研究では、様々なラジカル種(アルキルラジカル・活性酸素種)とDNAおよび核酸塩基との反応について、中間体の検出や各種速度論的解析の結果をもとに損傷機構の解明を行った。
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Report
(3 results)
Research Products
(155 results)
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[Journal Article] Aliphatic C-H Bond Activation Initiated by a (μ-η^2:η2-Peroxo)dicopper(II) Complex in Comparison with Cumylperoxyl Radical2009
Author(s)
Matsumoto, T., Ohkubo, K., Honda, K., Yazawa, A., Furutachi, H., Fujinami, S.,; Fukuzumi, S., Suzuki, M.
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Journal Title
J. Am. Chem. Soc. 131(in press)
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[Journal Article] Tuning Charge Transfer in Novel Reaction Center Mimics Based on Th-Functionalized Fullerenes2009
Author(s)
Spanig F., Kovacs, C., Hauke, F., Hartnagel, U., Ohkubo, K., Fukuzumi, S., Guldi, D. M., Hirsch, A.
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Journal Title
J. Am. Chem. Soc. 131(in press)
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[Journal Article] Metal Quinolinolate-Fullerene(s) Donor-Acceptor Complexes: Evidence for Organic LED Molecules Acting as Electron Donors in Photoinduced Electron-Transfer Reactions2008
Author(s)
D'Souza, F., Maligaspe, E., Zandler, M. E., Subbaiyan, N. K., Ohkubo, K., Fukuzumi, S.
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Journal Title
J. Am. Chem. Soc. 130
Pages: 16959-16967
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[Journal Article] "Umpolung" Photoinduced Charge Separation in an Anion-bound Supramolecular Complex2008
Author(s)
Sessler, J. L., Karnas, E., Kim, S. K., Ou, Z., Zhang, M., Kadish, K. M., Ohkubo, K., Fukuzumi, S.
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Journal Title
J. Am. Chem. Soc. 130
Pages: 15256-15257
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[Journal Article] (Pentamethylcyclopentadienyl)ruthenium π-Complexes of Metalloporphyrins: Platforms with Novel Photo- and Electrochemical Properties2008
Author(s)
Cuesta, L., Karnas, E., Kynch, V. M., Sessler, J. L., Kajonkijya, W., Zhu, W., Zhang, M., Ou, Z., Kadish, K. M., Ohkubo, K., Fukuzumi, S.
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Journal Title
Chem. Eur. J. 14
Pages: 10206-10210
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[Journal Article] Highly Selective Synthesis of the Ring-B Reduced Chlorins by Ferric Chloride Mediated Oxidation of Bacteriochlorins: Effects of the Fused Imide vs Isocyclic Ring in Photophysical and Electrochemical Properties2008
Author(s)
Liu, C., Dobhal, M. P., Ethirajan, M., Missert, J. R., Pandey, R. K., Balasubramanian, S., Sukumaran, D. K., Zhang, M., Kadish, K. M., Ohkubo, K., Fukuzumi, S.
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Journal Title
J. Am. Chem. Soc. 130
Pages: 14311-14323
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[Journal Article] A Discrete Supramolecular Conglomerate Composed of Two Saddle-Distorted Zinc(II)-Phthalocyanine Complexes and a Doubly Protonated Porphyrin with Saddle-Distortion Undergoing Efficient Photoinduced Electron Transfer2008
Author(s)
Kojima, T., Honda, T., Ohkubo, K., Shiro, M., Kusukawa, T., Fukuda, T., Kobayashi, N., Fukuzumi, S.
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Journal Title
Angew. Chem., Int. Ed. 47
Pages: 6712-6716
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[Journal Article] Androgynous Porphyrins. Silver(II) Quinoxalinoporphyrins Act as Both Good Electron Donors and Acceptors2008
Author(s)
Fukuzumi, S., Ohkubo, K., Zhu, W., Sintic, M., Khoury, T., Sintic, P. J., E, W., Ou, Z., Crossley, M. J., Kadish, K. M.
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Journal Title
J. Am. Chem. Soc. 130
Pages: 9451-9458
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[Journal Article] Face-to-Face Held Pacman Type Porphyrin-Fullerene Dyads : Design, Synthesis, Charge Transfer Interactions and Photophysical Studies2008
Author(s)
D'Souza, F., Maligaspe, E., Karr, P. A., Schumacher, A. L., Ojaimi, M. E., Gros, C. P., Barbe, J.-M., Ohkubo, K., Fukuzumi, S.
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Journal Title
hem. Eur. J. 14
Pages: 674-681
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[Journal Article] Constracting Photodynamics between Dithiapyrene-C60 and Pyrene-C60 Dyads2008
Author(s)
Guldi, D. M., Spaning, F., Kreher, D., Perepichka, I. F., Bryce, M. R., Ohkubo, K., Fukuzumi, S.
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Journal Title
Chem. Eur. J. 14
Pages: 250-258
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[Journal Article] Spectroscopic Characterization of Photolytically Generated Radical Ion Pairs in Single-Wall Carbon Nanotubes Bearing Surface-Immobilized Tetrathiafulvalens2008
Author(s)
Herranz, M. A., Ehli, C., Campidelli, S., Gutierrez, M., Hug, G. L., Ohkubo, K., Fukuzumi, S., Prato, M., Matin, N., Guldi, D. M.
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Journal Title
J. Am. Chem. Soc. 130
Pages: 66-73
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[Journal Article] Design and Synthesis of Polymetallic Complexes Based on meso-Calix[4]pyrrole : Platform for Multielectron Chemistry2007
Author(s)
Custa, L., Gross, D., Lynch, V. M., Ou, Z., Kajokiiya, W., Ohkubo, K., Fukuzumi, S., Kadish, K. M., J. L. Sessler
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Journal Title
J. Am. Chem. Soc. 129
Pages: 11696-11697
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[Journal Article] Selective Inclusion of Electron-Donating Molecules into Porphyrin Nanochannels Derived from Self-Assembly of Saddle-Distorted Dicationic Porphyrins and Photoinduced Electron Transfer from the Guest Molecules to the Porphyrin Dications2007
Author(s)
Kojima, T., Nakanishi, T., Harada, R., Ohkubo, K., Yamauchi, S., Fukuzumi, S.
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Journal Title
Chem. Eur. J. 36
Pages: 8714-8725
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[Journal Article] Synthesis and Characterization of Mononuclear Ruthenium(III)-Pyridylamine Complexes and Mechanistic Insights into Their Catalytic Alkene Functionalization with m-Chloroperbenzoic Acid2007
Author(s)
Kojima, T., Hayashi, K., Iizuka, S., Tani, F., Naruta, Y., Kawano, M., Ohashi, Y., Hirai, Y., Ohkubo, K., Fukuzumi, S.
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Journal Title
Chem. Eur. J. 13
Pages: 8212-8222
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[Journal Article] Intramolecular Electron Transfer within the Substituted Tetrathiafulvalene-Quinone Dyads : FAcilitated by Metal Ion and Photomodulation in the Presence of Spiropyran2007
Author(s)
Wu, H., Zhang, D., Su, L., Ohkubo, K., Zhang, C., Yin, S., Mao, L., Shuai, Z., Fukuzumi, S., Zhu, D.
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Journal Title
J. Am. Chem. Soc. 129
Pages: 6839-6846
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[Presentation] Electron-Transfer Properties of Substituted Bi-, Ter-, and Quaterpyrroles2007
Author(s)
Wenbo E, Kei Ohkubo, David Sanchez-Garcia, Elizabeth Karnas, Min Zhang, Jonathan L. Sessler, Shunichi Fukuzumi, Karl M. Kadisha
Organizer
211th ECS Meeting
Place of Presentation
Chicago, Illinois, USA
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