Development of Oxidant-Free Oxidation of Alcohols Catalyzed by Group 9 Metal Complexes and their Application to Organic Synthesis

• Project/Area Number: 19750075
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Synthetic chemistry
• Research Institution: Kyoto University
• Principal Investigator: FUJITA Ken-ichi Kyoto University, 地球環境学堂, 准教授 (80293843)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,680,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
• Keywords: 酸化反応 / アルコール / 脱水素 / ケトン / アルデヒド / イリジウム触媒 / ロジウム触媒 / イリジウム / 水素

Research Abstract

An efficient catalytic system for oxidant-free oxidation of alcohols has been developed by using group 9 metal complexes having functional ligands (hydroxypyridines, aminopyridines, and phenylpyridines) as catalysts. Various secondary and primary alcohols were converted to corresponding ketones and aldehydes, respectively, by catalytic dehydrogenative transformation. The present catalytic system exhibited the highest activity for dehydrogenative oxidation of alcohols among the reported systems.

Research Products

• [Journal Article] 9族金属錯体の水素移動触媒機能を活用する効率的有機合成反応の開発 (2008)
  • Author(s): 藤田健一
  • Journal Title: 有機合成化学協会誌 66 Pages: 322-331
  • NAID: 10021174381
  • Peer Reviewed
• [Journal Article] 9族金属錯体の水素移動触媒機能を活用する効率的有機合成反応の開発 (2008)
  • Author(s): 藤田 健一
  • Journal Title: 有機合成化学協会誌 66 Pages: 322-331
  • NAID: 10021174381
  • Peer Reviewed
• [Journal Article] Ligand-Promoted Dehydrogenation of Alcohols Catalyzed by Cp*Ir Complexes. A New Catalytic System for Oxidant-Free Oxidation of Alcohols (2007)
  • Author(s): Fujita, K., Tanino, N., Yamaguchi, R.
  • Journal Title: Org. Lett. 9 Pages: 109-111
  • Peer Reviewed
• [Presentation] 機能性キレート配位子を有するCp*イリジウム錯体触媒を用いた第一級アルコールの脱水素的酸化反応 (2010)
  • Author(s): 吉田哲也, 藤田健一, 山口良平
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
  • Year and Date: 2010-03-28
• [Presentation] 機能性キレート配位子を有するCp^*イリジウム錯体触媒を用いた第一級アルコールの脱水素的酸化反応 (2010)
  • Author(s): 藤田健一, 吉田哲也, 山口良平
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学(大阪府)
  • Year and Date: 2010-03-28
• [Presentation] 機能性ピリジン系配位子を有するCp*イリジウム錯体触媒を用いたアルコールの脱水素型酸化反応 (2009)
  • Author(s): 伊森洋一郎, 藤田健一, 山口良平
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 日本大学船橋キャンパス(千葉県)
  • Year and Date: 2009-03-28
• [Presentation] 機能性ピリジン系配位子を有するCp*イリジウム錯体触媒を用いたアルコールの脱水素型酸化反応 (2009)
  • Author(s): 伊森洋一郎
  • Organizer: 日本化学会第89春季年会
  • Place of Presentation: 千葉(日本大学船橋キャンパス
  • Year and Date: 2009-03-28
• [Presentation] New Catalysts for Oxidant-free Oxidation: Cp*Ir Complex-Catalyzed Dehydrogenative Oxidation of Alcohols (2007)
  • Author(s): Fujita, K., Tanino, N., Saito, H., Yamaguchi, R.
  • Organizer: 14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 14)
  • Place of Presentation: Nara Centennial Hall, Nara, Japan
  • Year and Date: 2007-08-03
• [Presentation] New Catalysts for Oxidant-free Oxidation: Cp*Ir Complex-Catalyzed Dehydrogenative Oxidation of Alcohols (2007)
  • Author(s): Ken-ichi Fujita
  • Organizer: 14th IUPAC International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS 14)
  • Place of Presentation: Nara, Japan
  • Year and Date: 2007-08-03
• [Book] Iridium Complexes in Organic Synthesis (Ed. Oro, L.A., Claver, C. ) (2009)
  • Author(s): Fujita, K., Yamaguchi, R.
  • Publisher: WILEY-VCH Verlag GmbH & Co. KGaA
• [Book] Iridium Complexes in Organic Synthesis (Ed. Oro, L. A., Claver, C. (2009)
  • Author(s): Ken-ichi Fujita
  • Publisher: WILEY-VCH Verlag GmbH & Co. KGaA