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One step synthesis of polysaccharide from free saccharide using direct activation method

Research Project

Project/Area Number 19750087
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Polymer chemistry
Research InstitutionTohoku University

Principal Investigator

NOGUCHI Masato  Tohoku University, 大学院・工学研究科, 助教 (10400285)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords酵素触媒重合反応 / 多糖合成 / 活性化糖誘導体 / ワンポット合成 / 水溶液中での脱水縮合反応 / 水溶液中での活性化 / キトオリゴ糖 / セロオリゴ糖
Research Abstract

多糖の化学-酵素合成法における合成法の簡略化を目的として,活性化糖モノマーの簡易合成法の確立と,ワンポットでの酵素触媒重合の検討を行った.その結果,活性化糖モノマーの合成においては収率良く対応するモノマーを得る方法を見出し,単離したものを用いて重合反応を行った結果,対応する多糖が得られることが分かった.しかし,ワンポットでの合成では酵素の失活等による重合反応の停止が見られた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Book (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Direct synthesis of 1,6-anhydro sugars from unprotected glycopyranoses by using 2-chloro-1,3-dimethylimidazolinium chloride2009

    • Author(s)
      Tomonari Tanaka, Wei Chun Huang, Masato Noguchi, Atsushi Kobayashi, and Shin-ichiro Shoda
    • Journal Title

      Tetrahedron Letters 50

      Pages: 2154-2157

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Sugar Oxazolines from Unprotected N-Acetyl-2-amino Sugars by Using Chloroformamidinium Reagent in Water2009

    • Author(s)
      Masato Noguchi, Tomonari Tanaka, Hidetoshi Gyakushi, Atsushi Kobayashi, and Shin-ichiro Shoda
    • Journal Title

      Journal of Organic Chemistry 74

      Pages: 2210-2212

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Sugar Oxazolines from Unprotected NAcetyl-2-a mino Sugars by Using Chloroformamidinium Reagent in Water2009

    • Author(s)
      Masato Noguchi, Tomonari Tana ka, Hidetoshi Gyakushi, Atsushi Kobayashi, and Shin-ichiro Shda
    • Journal Title

      Journal of Organic Chemistry 74

      Pages: 2210-2212

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct synthesis of 1,6-anhydro sugars from unprotected glycopyranoses by using 2-chloro-1,3-dimethylimidazolinium chloride2009

    • Author(s)
      Tomonari Tanaka, Wei Chun Hu ang, Masato Noguchi, Atsushi K obayashi, and Shin-ichiro Shoda
    • Journal Title

      Tetrahedron Letters 50

      Pages: 2154-2157

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel glycosyl donor for chemo-enzymatic oligosaccharide synthesis : 4,6-dimethoxy-1,3,5-triazin-2-ylglycoside2008

    • Author(s)
      Tomonari Tanaka, Masato Noguchi, Atsushi Kobayashi and Shin-ichiro Shoda
    • Journal Title

      Chemical Communications

      Pages: 2016-2018

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel glycosyl donor for chemo-enzymatic oligosaccharide synthesis : 4,6-dimethoxy-1,3,5-triazin-2-yl glycoside2008

    • Author(s)
      Tomonari Tanaka, Masato Noguchi, Atsushi Kobayashi and Shin-ichiro Shoda
    • Journal Title

      Chemical Communications

      Pages: 2016-2018

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 水溶液中での糖オキサゾリン誘導体の一段階合成2009

    • Author(s)
      野口真人・田中知成・小林厚志・正田晋一郎
    • Organizer
      日本化学会第89回春季年会
    • Place of Presentation
      船橋
    • Year and Date
      2009-03-29
    • Related Report
      2008 Final Research Report
  • [Presentation] トリアジン誘導体による糖の活性化と配糖化2008

    • Author(s)
      野口真人・田中知成・伊藤志保・木村敬一・渡部和仁・小林厚志・正田晋一郎
    • Organizer
      グライコサイエンス若手の会
    • Place of Presentation
      つくば
    • Year and Date
      2008-08-21
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 1,3,5-トリアジングリコシド-酵素触媒重合における新規モノマー2008

    • Author(s)
      野口真人・渡部和仁・三澤卓也・田中知成・小林厚志・正田晋一郎
    • Organizer
      第57回高分子学会年次大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-30
    • Related Report
      2008 Final Research Report
  • [Presentation] 1, 3, 5-トリアジングリコシド-酵素触媒重合における新規モノマー2008

    • Author(s)
      野口真人・渡部和仁・三澤卓也・田中知成・小林厚志・正田晋一郎
    • Organizer
      弟57会高分子学会年次大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] セルラーゼによる糖トリアジン誘導体の加水分解活性評価2008

    • Author(s)
      野口真人・田中知成・三澤卓也・渡部和仁・小林厚志・正田晋一郎
    • Organizer
      日本化学会第88回春季年会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-28
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] Synthesis of artificial cellulose from novel activated glycosides catalyzed by cellulase and related enzymes2007

    • Author(s)
      Masato Noguchi, Tomonari Tanaka, Masaki Ishihara, Atsushi Kobayashi and Shin-ichiro Shoda
    • Organizer
      International Cellulose Conference
    • Place of Presentation
      東京
    • Year and Date
      2007-10-22
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Book] セルロース利用技術の最先端2008

    • Author(s)
      正田晋一郎・小林厚志・野口真人
    • Publisher
      シーエムシー出版
    • Related Report
      2008 Final Research Report
  • [Book] セルロース利用技術の最先端2008

    • Author(s)
      正田晋一郎, 小林厚志, 野口真人
    • Publisher
      シーエムシー出版
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 配糖体及びその製造方法2008

    • Inventor(s)
      正田 晋一郎,小林 厚志,野口 真人,田中 知成,永井 光,松本 健
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-06-09
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] 配糖体及びその製造方法2008

    • Inventor(s)
      正田晋郎, 小林厚志, 野口真人, 田中知成, 永井光, 松本健
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2008-06-09
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] アンヒドロ糖及びその製造方法2007

    • Inventor(s)
      正田 晋一郎,小林 厚志,野口 真人,田中 知成
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2007-09-28
    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] アンヒロド糖およびその製造方法2007

    • Inventor(s)
      正田晋一郎, 小林厚志, 野口真人, 田中知成
    • Industrial Property Rights Holder
      東北大学
    • Filing Date
      2007-09-28
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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