Nanoparticle immobilized octacalcium phosphate scaffolds for bone regeneration

• Project/Area Number: 19750134
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemistry related to living body
• Research Institution: Tohoku University
• Principal Investigator: ANADA Takahisa Tohoku University, 大学院・歯学研究科, 助教 (30398466)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 生体機能材料 / リン酸オクタカルシウム / 遺伝子導入 / 骨再生

Research Abstract

本研究は、骨再生用担体材料(リン酸オクタカルシウム;OCP)の開発およびOCPと遺伝子導入法を一体化することにより、これまでにない迅速で安全性の高い新規骨再生遺伝子治療法の開発を行うことを目的とした。二年間の研究期間においてOCPとアテロコラーゲンを複合化したOCPICollagen担体を作製と担体表面に特異的に吸着するナノ粒子の検討を行った。これまでにナノ粒子の作製に成功し、担体への吸着法を確立した。また、OCP及びOCP/Collagen担体の骨再生担体としての基礎的知見を得ることができた。

Research Products

• [Journal Article] Syntheric octacalcium phosphate augments bone regeneration correlated with its content in collagen scaffold (2009)
  • Author(s): T. Kawai, T. Anada, Y. Honda, S. Kamakura, K. Matsui, A. Matsui, K. Sasaki, S. Morimoto, S. Echigo, O. Suzuki
  • Journal Title: Tissue Eng PartA 15 Pages: 23-32
  • Peer Reviewed
• [Journal Article] Synthetic octacalcium phosphate augments bone regeneration correlated with its content in collagen scaffold (2009)
  • Author(s): Kawai T, et.al.
  • Journal Title: Tissue Engineering Part A 15 Pages: 23-32
  • Peer Reviewed
• [Journal Article] Dose-Dependent Osteogenic Effect of Octacalcium Phosphate on Mouse Bone Marrow Stromal Cells (2008)
  • Author(s): T. Anada, T. Kumagai, Y. Honda, T. Masuda, R. Kamijo, S. Kamakura, N. Yoshihaza, T. Kuriyagawa, H. Shimauchi, O. Suzuki
  • Journal Title: Tissue Engineering 14 Pages: 965-978
  • Peer Reviewed
• [Journal Article] Dose-Dependent Osteogenic Effect of Octacalcium Phosphate on Mouse Bone Marrow Stromal Cells
  • Author(s): Anada T, et. al.
  • Journal Title: Tissue Engineering (In press)
  • Peer Reviewed
• [Presentation] リン酸カルシウムに特異的に結合するリポソームの合成と応用 (2008)
  • Author(s): 穴田貴久、武田陽一、櫻井和朗、鈴木治
  • Organizer: 日本バイオマテリアル学会シンポジウム2008
  • Place of Presentation: 東京
• [Presentation] Osteoblastic cell differentiation of mouse bone marrow stromal cells on synthetic octacalcium phosphate (2007)
  • Author(s): T. Anada, T. Kumagai, Y. Honda, S. Kamakura, H. Shimauchi, O. Suzuki
  • Organizer: The seventh Asian Bioceramics Symposium 2007
  • Place of Presentation: 大阪
• [Book] Environmental Biodegradation Research Focus (2008)
  • Author(s): Anada, T., et. al.
  • Total Pages: 12
  • Publisher: Nova Science Publishers Inc
• [Book] Biodegradable synthetic octacalcium phosphate bone substitute. Environmental Biodegradation Research Focus (2007)
  • Author(s): T. Anada, H. Imaizumi, S. Kamakura, and O. Suzuki
  • Publisher: Nova Science Publishers Inc.
• [Remarks]
  • URL: http://www-kiso.dent.tohoku.ac.jp/cfe/index.html