Development of Near-field Fluorescent Thermal Nanoscopy for Single MoIecule Thermal Control

• Project/Area Number: 19760138
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Thermal engineering
• Research Institution: Keio University
• Principal Investigator: TAGUCHI Yoshihiro Keio University, 理工学部, 助教 (30433741)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,480,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,700,000 (Direct Cost: ¥2,700,000)
• Keywords: ナノバイオ / 熱工学 / 走査プローブ顕微鏡 / マイクロ・ナノデバイス / 計測工学 / 熱光学 / 走査顕微プローブ / 計測技術

Research Abstract

ノム創薬やテーラーメード医療の飛躍的な進展のためには、生体分子の構造と諸性質のナノレベルでの解明が必要不可欠である。特に生体分子モーターやヒートショックプロテインに代表される機能性たんぱく質の温度応答特性のナノレベル分析は細胞のメカニズムを分子レベルで解明する上で無くてはならない。本研究では、ナノメートル空間分解能を有する近接場蛍光熱顕微鏡を原理の段階から開発し、ナノレベルの高感度温度計測技術を確立するに至った。

Research Products

• [Journal Article] Development of Near-field Life-time Thermometry (2009)
  • Author(s): Taguchi, Y., Oka, T., Saiki, T., and Nagasaka, Y.
  • Journal Title: Nanoscale and Microscale Thermophysical Engineering (in press)
  • Peer Reviewed
• [Journal Article] Development of Near-field Fluorescence Life-time Thermometry (2009)
  • Author(s): Taguchi, Y.
  • Journal Title: Nanoscale and Microscale Thermophysical Engineering (掲載決定)
  • Peer Reviewed
• [Journal Article] Miniaturized optical viscosity sensor based on a laser-induced capillary wave (2008)
  • Author(s): Taguchi, Y., Ebisui, A., and Nagasaka, Y.
  • Journal Title: Journal of Optics A : Pure and Applied Optics Vol.10, No.4 Pages: 44008-44013
  • Peer Reviewed
• [Journal Article] Development of Nanoscale Temperature Measurement Technique Using Near-field Fluorescence (2008)
  • Author(s): Jigami, T.
  • Journal Title: Int. J. Thermophys 28 Pages: 968-979
  • Peer Reviewed
• [Journal Article] Development of Nanoscale Temperature Measurement Technique Using Near-field Fluorescence (2008)
  • Author(s): T. Jigami
  • Journal Title: Int. J. Thermophys. 28 Pages: 968-979
  • Peer Reviewed
• [Journal Article] Miniaturized optical viscosity sensor based on a laser-induced capillary wave (2008)
  • Author(s): Y. Taguchi
  • Journal Title: J. Opt. A: Pure Appl. Opt. 10 Pages: 44008-44013
  • Peer Reviewed
• [Journal Article] Development of Nanoscale Temperature Measurement Technique Using Near-field Fluorescence (2007)
  • Author(s): Jigami, T., Kobayashi, M., Taguchi, Y and Nagasaka, Y.
  • Journal Title: Development of Nanoscale Temperature Measurement Technique Using Near-field Fluorescence Vol.28, No.3 Pages: 968-979
  • Peer Reviewed
• [Presentation] Development of high sensitivity nanoscale temperature detection by polarized near-field light (2008)
  • Author(s): Kasakake, T., Taguchi, Y., Saiki, T., and Nagasaka, Y.
  • Organizer: The 18th European Conference on Thermophysical Properties
  • Place of Presentation: Pau, France
  • Year and Date: 2008-09-02
• [Presentation] Development of high sensitivity nanoscale temperature detection by polarized near-field light (2008)
  • Author(s): Kasakake, T.
  • Organizer: 18th European Conference on Thermophysical Properties
  • Place of Presentation: Pau, France
  • Year and Date: 2008-09-02
• [Presentation] 位相分解蛍光寿命測定法と近接場顕微技術を用いたナノスケール温度測定法の開発 (2008)
  • Author(s): 岡巧,地紙平,田口良広,斎木敏治,長坂雄次
  • Organizer: 第45回日本伝熱シンポジウム
  • Place of Presentation: 日本伝熱学会,筑波
  • Year and Date: 2008-05-21
• [Presentation] 位相分解蛍光寿命測定法と近接場顕微技術を用いたナノスケール温度測定法の開発 (2008)
  • Author(s): 岡巧
  • Organizer: 第45回日本伝熱シンポジウム
  • Place of Presentation: つくば国際会議場
  • Year and Date: 2008-05-21
• [Presentation] 近接場蛍光寿命を用いたナノスケール温度計測法の開発 (2007)
  • Author(s): 地紙平,田口良広,斎木敏治,長坂雄次
  • Organizer: 第28回日本熱物性シンポジウム
  • Place of Presentation: 日本熱物性学会,札幌
  • Year and Date: 2007-10-25
• [Presentation] 近接場蛍光寿命を用いたナノスケール温度計測法の開発 (2007)
  • Author(s): 地紙 平
  • Organizer: 第28回日本熱物性シンポジウム
  • Place of Presentation: 札幌