Study on Adaptive Response of a Cell Modeled as an Intelligent Structural System

• Project/Area Number: 19760152
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dynamics/Control
• Research Institution: Yokohama National University
• Principal Investigator: SHIRAISHI Toshihiko Yokohama National University, 大学院環境情報研究院, 講師 (30361877)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,600,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥2,300,000 (Direct Cost: ¥2,300,000)
• Keywords: 機械力学・制御 / モデル化 / 細胞・組織 / シグナル伝達 / 振動 / 振動数 / 骨芽細胞 / 骨

Research Abstract

本研究では、細胞を知的構造システムとして捉えて、細胞がセンサ、コントローラ、アクチュエータを有すると考え、機械的刺激が骨芽細胞に入力された場合の適応的応答を実験的に検証し、その動的モデルを構築することを目的とした。その結果、細胞の機械的刺激感受システムは振動数依存性を示し、振動数12.5〜1000Hz、加速度振幅0.125〜0.5Gの実験範囲では、振動数が低いほど細胞増殖が亢進し、50Hzに骨形成の極大値が存在することを示した。

Research Products

• [Journal Article] 3次元軟骨細胞に及ぼす超音波刺激の影響 (2008)
  • Author(s): 白石俊彦、竹内良平、森下 信、松永家朋、高垣裕子、齋藤知行
  • Journal Title: 運動・物理療法 Vol. 19、No. 3 Pages: 154-161
  • NAID: 10024476955
• [Journal Article] 3次元軟骨細胞に及ぼす超音波刺激の影響 (2008)
  • Author(s): 白石俊彦, 竹内良平, 森下信, 松永家朋, 高垣裕子, 齋藤知行
  • Journal Title: 運動・物理療法 19巻3号 Pages: 154-161
  • NAID: 10024476955
• [Journal Article] Effects of Amplitude and Frequency of Mechanical Vibration Stimulation on Cultured Osteoblasts (2008)
  • Author(s): Tetsuo Shikata
  • Journal Title: Journal of System Design and Dynamics Vol.2,No.1 Pages: 382-388
  • Peer Reviewed
• [Presentation] 3次元培養軟骨細胞の増殖および基質産生に対する機械的振動の影響 (2009)
  • Author(s): 高木裕太
  • Organizer: 日本機械学会第21回バイオエンジニアリング講演会
  • Year and Date: 2009-01-23
• [Presentation] 神経幹細胞の増殖および分化に対する機械的振動の影響 (2009)
  • Author(s): 鈴木圭
  • Organizer: 日本機械学会第21回バイオエンジニアリング講演会
  • Place of Presentation: 札幌
  • Year and Date: 2009-01-23
• [Presentation] 3次元培養軟骨細胞の増殖および基質産生に対する機械的振動の影響 (2009)
  • Author(s): 高木裕太
  • Organizer: 日本機械学会第21回バイオエンジニアジング講演会
  • Place of Presentation: 札幌
  • Year and Date: 2009-01-23
• [Presentation] EFFECTS OF MECHANICAL VIBRATION ON MATRIX PRODUCTION AND PROLIFERATION OF THREE-DIMENSIONAL CULTURED CHONDROCYTES (2008)
  • Author(s): Yuta Takagi
  • Organizer: The ASME 2008 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] EFFECTS OF MECHANICAL VIBRATION ON PROLIFERATION AND DIFFERENTIATION OF NEURAL STEM CELLS (2008)
  • Author(s): Kei Suzuki
  • Organizer: The ASME 2008 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] EFFECTS OF ACCELERATION AMPLITUDE AND FREQUENCY OF MECHANICAL VIBRATION ON CULTURED OSTEOBLASTS (2008)
  • Author(s): Toshihiko Shiraishi
  • Organizer: The ASME 2008 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] MEASUREMENT OF DYNAMIC VISCOELASTICITY OF AN OSTEOBLAST UNDER ADHESIVE CONDITION USING A PIEZOELECTRIC VIBRATOR (2008)
  • Author(s): Toshihiko Shiraishi
  • Organizer: The ASME 2008 International Design Engineering Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] MEASUREMENT OF DYNAMIC VISCOELASTICITY OF AN OSTEOB LAST UNDER ADHESIVE CONDITION USING A PIEZOELECTRIC V IBRATOR (2008)
  • Author(s): Toshihiko Shiraishi
  • Organizer: The ASME 2008 International Design Engineerin g Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] EFFECTS OF ACCELERATION AMPLITUDE AND FREQUENCY OF MECHANICAL VIBRATION ON CULTURED OSTEOBLASTS (2008)
  • Author(s): Toshihiko Shiraishi
  • Organizer: The ASME 2008 International Design Engineerin g Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] EFFECTS OF MECHANICAL VIBRATION ON PROLIFERATION AND DIFFERENTIATION OF NEURAL STEM CELLS (2008)
  • Author(s): Kei Suzuki
  • Organizer: The ASME 2008 International Design Engineerin g Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] EFFECTS OF MECHANICAL VIBRATION ON MATRIX PRODUCTION AND PROLIFERATION OF THREE-DIMENSIONAL CULTURED CHONDROCYTES (2008)
  • Author(s): Kei Suzuki
  • Organizer: The ASME 2008 International Design Engineerin g Technical Conferences & Computers and Information in Engineering Conference
  • Place of Presentation: 米国・ボストン
  • Year and Date: 2008-11-04
• [Presentation] 機械的振動の振幅および振動数が培養骨芽細胞に与える影響 (2008)
  • Author(s): 白石俊彦
  • Organizer: 第23回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-24
• [Presentation] 機械的振動が3次元培養軟骨細胞に及ぼす影響 (2008)
  • Author(s): 高木裕太
  • Organizer: 日本機械学会機械力学・計測制御部門講演会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-03
• [Presentation] 機械的振動が神経幹細胞に及ぼす影響 (2008)
  • Author(s): 鈴木圭
  • Organizer: 日本機械学会機械力学・計測制御部門講演会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-03
• [Presentation] 機械的振動が神経幹細胞に及ぼす影響 (2008)
  • Author(s): 鈴木圭
  • Organizer: 日本機械学会機械力学.計測制御部門講演会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-03
• [Presentation] 3次元培養軟骨細胞に対する機械的振動の影響 (2008)
  • Author(s): 高木裕太
  • Organizer: 日本機械学会2008年度年次大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-08-05
• [Presentation] 神経幹細胞に対する機械的振動の影響 (2008)
  • Author(s): 鈴木圭
  • Organizer: 日本機械学会2008年度年次大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-08-05
• [Presentation] 三次元培養軟骨細胞に対する超音波刺激およびヒアルロン酸の影響 (2008)
  • Author(s): 白石俊彦
  • Organizer: 第81回整形外科学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2008-05-25
• [Presentation] 培養骨芽細胞に及ぼす機械的振動刺激の振幅および振動数の影響 (2008)
  • Author(s): 鹿田哲生
  • Organizer: 日本機械学会第20回バイオエンジニアリング講演会
  • Place of Presentation: 東京
  • Year and Date: 2008-01-25
• [Presentation] 培養骨芽細胞に対する振動刺激の振幅および振動数の影響 (2008)
  • Author(s): 鹿田哲生
  • Organizer: 第11回超音波骨折治療研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-01-19
• [Presentation] Effects of Acceleration Amplitude and Frequency of Mechanical Vibration on Osteoblast-like Cells (2007)
  • Author(s): Toshihiko Shiraishi
  • Organizer: The 2007 ASME International Mechanical Engine ering Congress and Exposition
  • Place of Presentation: 米国・ラスベガス
  • Year and Date: 2007-11-14
• [Presentation] 機械的振動が培養骨芽細胞に与える影響 (2007)
  • Author(s): 白石俊彦
  • Organizer: 第22回日本整形外科学会基礎学術集会
  • Place of Presentation: 浜松
  • Year and Date: 2007-10-25
• [Presentation] 培養骨芽細胞に及ぼす機械的振動の振幅および振動数の影響 (2007)
  • Author(s): 鹿田哲生
  • Organizer: 日本機械学会機械力学・計測制御部門講演会
  • Place of Presentation: 広島
  • Year and Date: 2007-09-28
• [Presentation] Viscoelastic Properties of a Cultured Osteoblast under Adhesive Condition (2007)
  • Author(s): Toshihiko Shiraishi
  • Organizer: The ASME 2007 International Design Engineering Technical Conferences & Computers and Inform ation in Engineering Conference
  • Place of Presentation: 米国・ラスベガス
  • Year and Date: 2007-09-07
• [Presentation] Effects of Amplitude and Frequency of Vibration Stimulation on Cultured Osteoblasts (2007)
  • Author(s): Tetsuo Shikata
  • Organizer: The ASME 2007 International Design Engineering Technical Conferences & Computers and Inform ation in Engineering Conference
  • Place of Presentation: 米国・ラスベガス
  • Year and Date: 2007-09-07
• [Presentation] Viscoelasticity of a Cultured Osteoblast under Adhesive Condition (2007)
  • Author(s): Toshihiko Shiraishi
  • Organizer: 12th Asia Pacific Vibration Conference
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-07
• [Presentation] Effects of Amplitude and Frequency of Vibration Stimulation on Cultured Osteoblasts (2007)
  • Author(s): Tetsuo Shikata
  • Organizer: 12th Asia Pacific Vibration Conference
  • Place of Presentation: 札幌
  • Year and Date: 2007-08-07
• [Book] 振動数による細胞増殖・産生基質量の変化の超音波治療への応用(超音波TECHNO, Vol. 20, No. 1(2008)内) (2008)
  • Author(s): 白石俊彦
  • Publisher: 日本工業出版
• [Remarks] 白石俊彦、骨細胞増殖 最適な振動数を特定、日刊工業新聞、2009年3月18日1面記事
• [Remarks]
  • URL: http://kenkyu-web.jmk.ynu.ac.jp/Profiles/0013/0000576/profile.html
• [Remarks]
  • URL: http://kenkyu-web.jmk.ynu.ac.jp/Profiles/0013/0000576/profile.html