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Development of biomaterials using plasma and ion processes

Research Project

Project/Area Number 19760498
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Structural/Functional materials
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

KOBAYASHI Tomohiro  The Institute of Physical and Chemical Research, 山崎原子物理研究室, 専任研究員 (40282496)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,350,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordsプラズマイオン注入 / 細胞接着 / 生体適合性 / シリコーン / 炭素化 / PBII / PTFE / ダイヤモンドライクカーボン / フッ素化ダイヤモンドライクカーボン
Research Abstract

In this study the surfaces of Silicones (polydimethylsiloxane) were irradiated with ions by a plasma based ion implantation (PBII) method and changes in their composition, structure, morphology and biocompatibility were investigated. Due to the morphological and the structural changes, the cell attachment percentage and growth rate were improved. The optimal irradiation voltage was between 2.5 and 5 kV. The Raman spectra showed a destruction of siloxane bonds and formation of amorphous carbon structures.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (27 results)

All 2009 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (14 results) Remarks (2 results)

  • [Journal Article] イオン照射による高分子材料の組織適合性向上2009

    • Author(s)
      小林知洋, 鈴木嘉昭
    • Journal Title

      材料の科学と工学 Vol.46,No.4

      Pages: 169-173

    • NAID

      10025569224

    • Related Report
      2009 Final Research Report
  • [Journal Article] 体親和性材料の開発2009

    • Author(s)
      小林知洋, 鈴木嘉昭
    • Journal Title

      放射線と産業 No.123

      Pages: 23-27

    • Related Report
      2009 Final Research Report
  • [Journal Article] Cell attachment on surface carbonized polymers by ion irradiation2009

    • Author(s)
      T. Kobayashi
    • Journal Title

      Proceedings of international conference of carbon

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell attachment on surface carbonized polymers by ion irradiation2009

    • Author(s)
      小林知洋
    • Journal Title

      Proceedings of international conference of carbon 2009 電子媒体

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体親和性材料の開発2009

    • Author(s)
      小林知洋
    • Journal Title

      放射線と産業 123

      Pages: 23-27

    • Related Report
      2009 Annual Research Report
  • [Journal Article] イオン照射による高分子材料の組織適合性向上2009

    • Author(s)
      小林知洋
    • Journal Title

      材料の科学と工学 46

      Pages: 169-173

    • NAID

      10025569224

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Surface modification of silicone sheets and tubes using plasma-based ion implantation2007

    • Author(s)
      T. Kobayashi, R. Katou, T. Yokota, Y. Suzuki, M. Iwaki, T. Terai
    • Journal Title

      Surface and Coatings Technology Vol.201

      Pages: 8039-8042

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface modification of silicone medical materials by plasma-based ion implantation2007

    • Author(s)
      T. Kobayashi, T. Yokota, R. Kato, Y. Suzuki, M. Iwaki, T. Terai, N. Takahashi, T. Miyasato, H. Ujiie
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B Vol.257

      Pages: 128-131

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Surface modification of silicone sheets and tubes using plasma-based ion implantation2007

    • Author(s)
      小林知洋
    • Journal Title

      Surface and Coatings Technology 201

      Pages: 8039-8042

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell adhesion to nitrogen-doped DLCs fabricated by plasma-based ion implantation and deposition method using toluene gas2007

    • Author(s)
      横田敏彦
    • Journal Title

      Surface and Coatings Technology 201

      Pages: 8048-8051

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surface modification of silicone medical materials by plasma-based ion implantation2007

    • Author(s)
      小林知洋
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section B 257

      Pages: 128-131

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bioaffinity of carbonized polymers by plasma ion irradiation2009

    • Author(s)
      T. Kobayashi
    • Organizer
      1st German - Japanese Joint Symposium Development and Technology of Carbon Materials
    • Place of Presentation
      Meitingen, Germany
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Cell attachment on surface carbonized polymers by ion irradiation2009

    • Author(s)
      T. Kobayashi
    • Organizer
      International conference of carbon 2009
    • Place of Presentation
      Biarritz, France
    • Year and Date
      2009-06-17
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Surface modification of polymers by plasma based ion implantation2008

    • Author(s)
      T. Kobayashi
    • Organizer
      IUMRS-ICA2008
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Surface modification of polymers by plasma based ion implantation2008

    • Author(s)
      小林知洋
    • Organizer
      IUMRS-ICA2008
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Composition Control of Doped DLCs Fabricated by PBIID and their Structural Change at High Temperature2008

    • Author(s)
      H. Hirakata, T. Kobayashi
    • Organizer
      IUMRS-ICA2008
    • Year and Date
      2008-12-10
    • Related Report
      2009 Final Research Report
  • [Presentation] Composition Control of Doped DLCs Fabricated by PBIID and their Structural Change at High Temperature2008

    • Author(s)
      平方史生
    • Organizer
      IUMRS-ICA2008
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] ハロゲン・金属をドープしたDLCの高温酸化挙動2008

    • Author(s)
      平方史生, 小林知洋
    • Organizer
      第65回炭素材料学会年会
    • Year and Date
      2008-12-05
    • Related Report
      2009 Final Research Report
  • [Presentation] ハロゲン・金属をドープしたDLCの高温酸化挙動2008

    • Author(s)
      平方史生
    • Organizer
      第65回炭素材料学会年会
    • Place of Presentation
      筑波大学
    • Year and Date
      2008-12-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 異種元素ドープDLCの組成制御および高温下における構造変化2008

    • Author(s)
      平方史生, 小林知洋
    • Organizer
      第69回応用物理学会学術講演会
    • Year and Date
      2008-09-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Surface modification of polymers by plasma based ion implantation2008

    • Author(s)
      T. Kobayashi
    • Organizer
      Ion beam modification of materials 2008
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2008-09-02
    • Related Report
      2009 Final Research Report
  • [Presentation] Surface modification of polymers by plasma based ion implantation2008

    • Author(s)
      小林知洋
    • Organizer
      Ion beam modification of materials 2008
    • Place of Presentation
      ドレスデン工科大学、ドイツ
    • Year and Date
      2008-09-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] 異種元素ドープDLCの組成制御および高温下における構造変化2008

    • Author(s)
      平方史生
    • Organizer
      第69回応用物理学会学術講演会
    • Place of Presentation
      中部大学
    • Year and Date
      2008-09-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] プラズマイオン注入法による医療高分子の表面改質2007

    • Author(s)
      河合雄毅, 小林知洋
    • Organizer
      第64回炭素材料学会年会
    • Year and Date
      2007-11-30
    • Related Report
      2009 Final Research Report
  • [Presentation] プラズマイオン注入法による医療高分子の表面改質2007

    • Author(s)
      河合雄毅
    • Organizer
      炭素材料学会
    • Place of Presentation
      別府市国際会議場
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.riken.jp/ap/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.riken.jp/ap/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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