Surface Modification of Nanoparticles for Bio?imaging Using Pressure?induced Phase Separation of Supercritical Fluids

• Project/Area Number: 19760537
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Reaction engineering/Process system
• Research Institution: Fukuoka University
• Principal Investigator: MATSUYAMA Kiyoshi Fukuoka University, 工学部, 助教 (40299540)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
• Keywords: 気 / 液 / 固 / 超臨界流体反応操作 / ナノ材料 / 超臨界流体 / 表面修飾 / 生体分子 / 分子間相互作用 / ナノ粒子 / 分散技術 / 二酸化炭素 / 分子イメージング / 生体認識 / 相分離

Research Abstract

超臨界および液体状態の二酸化炭素中での圧力誘起相分離法を利用したマイクロ・ナノ粒子の表面修飾技術について検討し、マイクロ・ナノ粒子の高分子による表面改質に成功した。また、高圧下でも利用可能な高出力型超音波分散装置を試作し、高圧状態の二酸化炭素雰囲気下においてもナノ粒子の分散が可能であることを示した。また、分光学的手法を用いて分子レベルでの二酸化炭素に対する高分子の溶解メカニズムについても明らかにした。

Research Products

• [Journal Article] Fourier Transform Infrared Study of Dissolutior Mechanism of Poly(methyl methacrylate) in CO2-expanded Ethanol (2009)
  • Author(s): K. Matsuyama, K. Mishima
  • Journal Title: ChemPhysChem 10 Pages: 503-506
  • Peer Reviewed
• [Journal Article] Fourier Transform Infrared Study of Dissolution Mechanism of Poly(methyl methacrylate) in CO_2-expanded Ethanol (2009)
  • Author(s): K. Matsuyama, K. Mishima
  • Journal Title: ChemPhysChem 10 Pages: 503-506
  • Peer Reviewed
• [Journal Article] Phase Behavior of the Mixtures of CO2 + Poly(methyl methacrylate) + Ethanol at High Pressure (2008)
  • Author(s): K. Matsuyama, K. Mishima
  • Journal Title: J. Chem. Eng. Data 53 Pages: 1151-1154
  • Peer Reviewed
• [Journal Article] 超臨界二酸化炭素中での高速撹拝技術を利用した酸化チタンナノ粒子内包マイクロカプセルの製造 (2008)
  • Author(s): 三島健司,松山清
  • Journal Title: 化学工学シンポジウムシリーズ 80 Pages: 29-34
• [Journal Article] 二酸化炭素飽和溶液の圧力誘起相分離を利用した無機粒子のコーティング (2008)
  • Author(s): 本城政稔,松山清,三島健司,藤原道弘
  • Journal Title: 工学シンポジウムシリーズ 80 Pages: 35-40
• [Journal Article] Phase Behavior of the Mixtures of CO_2+Poly(methyl methacrylate)+Ethanol at High Pressure (2008)
  • Author(s): K. Matsuyama, K. Mishima
  • Journal Title: J. Chem. Eng. Data 53 Pages: 1151-1154
  • Peer Reviewed
• [Journal Article] Coacervat ion Microencapsulation of Talc Particles with Poly (methyl methacrylate) by Pressure-Induced Phase Separation of CO2-Expanded Ethanol Solutions (2007)
  • Author(s): K. Matsuyama, K. Mishima
  • Journal Title: Ind. Eng. Chem. Res 46(199 Pages: 6244-6250
  • Peer Reviewed
• [Journal Article] Coacervation Microencapsulation of Talc Particles with Poly(thylmethacrylate)by Pressure-Induced Phase Separation of CO_2-Eχpanded Ethanol Solutions (2007)
  • Author(s): K.Matsuyama, K.Mishima
  • Journal Title: Ind, Eng. Chem. Res. 46(19) Pages: 6244-6250
  • Peer Reviewed
• [Journal Article] Preparation of Poly (methyl methacrylate)-TiO2, Nanoparticle Composites by Pseudo?dispersion Polymerization of Methyl Methacrylate in Supercritical CO2
  • Author(s): K. Matsuyama, K. Mishima
  • Journal Title: J. Supercritical Fluids (印刷中)
  • Peer Reviewed
• [Journal Article] Preparation of poly(methyl methacrylate)-TiO_2 nanoparticle composites by pseudo-dispersion polymerization of methyl methacrylate in supercritical CO_2
  • Author(s): K. Matsuyama, K. Mishima
  • Journal Title: J. Supercritical Fluids (印刷中)
  • Peer Reviewed
• [Journal Article] Phase Behavior of the Mixtures of C0_2 +Poly(methyl methacrylate)+Ethanol at High Pressure
  • Author(s): K.Matsuyama, K.Mishima
  • Journal Title: J. Chem. Eng. Data (印刷中)
  • Peer Reviewed
• [Presentation] CO2膨張液体中への高分子の溶解とFT-IRによる溶解挙動の解析 (2009)
  • Author(s): 松山清,三島健司
  • Organizer: 化学工学会第74年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-20
• [Presentation] 超臨界二酸化炭素を用いた無機多孔体微粒子のコーティング (2009)
  • Author(s): 三島健司,松山清
  • Organizer: 化学工学会第74年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-20
• [Presentation] CO_2膨張液体中への高分子の溶解とFT-IRによる溶解挙動の解析 (2009)
  • Author(s): 松山清, 三島健司
  • Organizer: 化学工学会第74年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-20
• [Presentation] 二酸化炭素飽和溶液の圧力誘起相分離を利用した無機粒子のコーティング (2008)
  • Author(s): 三島健司,松山清
  • Organizer: 化学工学会沖縄大会
  • Place of Presentation: 沖縄
  • Year and Date: 2008-08-08
• [Presentation] Measurement of Solubility of Astaxanthin and Beta Carotene in Supercritical Carbon Dioχide by FT-IR Spectroscopy (2007)
  • Author(s): K.Mishima, K.Matsuyama, Y.Sasaki, M.Nishino, T.Miuchi
  • Organizer: The 8th Asian Thermophysical Properties Conference
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2007-08-24
• [Presentation] Miuchi,Measurement of Solubility of Astaxanthin and 13?Carotene in Supercritical Carbon Dioxide by FT?IR Spectroscopy (2007)
  • Author(s): K. Mishima, K. Matsuyama, Y. Sasaki, M. Nishino, T. Miuchi
  • Organizer: Proceedings of the 8th Asian Thermophysical Properties Conference
  • Place of Presentation: 福岡
  • Year and Date: 2007-08-23