| Budget Amount *help |
¥3,030,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
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| Research Abstract |
An oral dosage form of insulin is thus desirable to achieve a safe and convenient insulin delivery that leads to high patient compliance. However, there are several barriers for the oral delivery of insulin such as enzymatic degradation in the gastrointestinal (GI) tract and low permeability across the intestinal mucosa. In this study, a new type of mucoadhesive patches for oral insulin dosage was prepared. The advantages of the mucoadhesive patch system are as follows: (1) patch can maintain its position in small intestine for a few hours; (2) drug release is a unidirectional way toward intestine mucosa ; (3) drug impermeant layer can protect from degradation by proteolytic enzymes.
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