Molecular recognition and structure formations of nucleic acids under unusual molecular environments
| Project/Area Number |
19760557
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Konan University |
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Principal Investigator |
NAKANO Shu-ichi Konan University, フロンティアサイエンス学部, 准教授 (70340908)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 分子クラウディング / ポリエチレングリコール / 金属イオン / DNA構造 / ヘアピン構造 / ハンマーヘッドリボザイム / 結合エネルギー / 核酸 / i-motif構造 / 機能性核酸 / 構造安定性 / 細胞内分子環境 / Z型構造 / リボザイム / PEG / ヘアピンDNA / ポリアミン / 塩基性ペプチド |
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| Research Abstract |
DNA is widely used in biotehnology, and the DNA properties under unusual conditions, such as in living cells and on biochips, are the critical issue for the success of biotechnology. Due to the polyelectronic nature of DNA and RNA, significant influences of molecular environment on their functions, including molecular recognitions and structure formations, are expected. Here, we have found facilitations of unusual structure formations of DNA relevant to gene regulations, and enhancements of the catalytic activity of an RNA enzyme. These finding could lead to applications as monitoring molecular environment and design of functional oligonucleotides that efficiently function under unusual conditions applied for biotechnology.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Conformation and the sodium ion condensation on DNA and RNA structures in the presence of a neutral cosolute as a mimic of the intracellular media.2008
Author(s)
S. Nakano, L. Wu, H. Oka, H.T. Karimata, T. Kirihata, Y. Sato, S. Fujii, H. Sakai, M. Kuwahara, H. Sawai, N. Sugimoto
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Journal Title
Mol. BioSyst. 4
Pages: 579-588
Related Report
Peer Reviewed
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